Detailed information of TA system TA076618

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 129823..130288
• Replicon: chromosome
• Accession: NZ_CP021431
• Organism: Yoonia vestfoldensis strain SMR4r

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LOKVESSMR4R_RS00615
• Protein ID: WP_087205783.1
• Coordinates: 129823..130086 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A1Y5TQY4
• Locus tag: LOKVESSMR4R_RS00620
• Protein ID: WP_066009074.1
• Coordinates: 130073..130288 (+)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOKVESSMR4R_RS00595	126590..127666	+	1077	WP_087205777.1	ribosome small subunit-dependent GTPase A	-
LOKVESSMR4R_RS00600	128107..128562	-	456	WP_087212298.1	hypothetical protein	-
LOKVESSMR4R_RS00605	128565..128984	-	420	WP_087205779.1	hypothetical protein	-
LOKVESSMR4R_RS00610	129161..129661	+	501	WP_157898091.1	hypothetical protein	-
LOKVESSMR4R_RS00615	129823..130086	+	264	WP_087205783.1	BrnT family toxin	Toxin
LOKVESSMR4R_RS00620	130073..130288	+	216	WP_066009074.1	CopG family transcriptional regulator	Antitoxin
LOKVESSMR4R_RS00625	130388..132028	+	1641	WP_087205784.1	hypothetical protein	-
LOKVESSMR4R_RS00630	131983..133584	+	1602	WP_157898092.1	Eco57I restriction-modification methylase domain-containing protein	-
LOKVESSMR4R_RS00635	133697..134446	+	750	WP_157898093.1	hypothetical protein	-
LOKVESSMR4R_RS00640	134751..135005	+	255	WP_087205790.1	type II toxin-antitoxin system HicA family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	gmd	652..170927	170275

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-80)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10214.36 Da
• Isoelectric Point: 5.6327

>T76618 WP_087205783.1 NZ_CP021431:129823-130086 [Yoonia vestfoldensis]
MKFEYDPDKSTANREKHGIDFDEAQALWNDPYLIEAPANVTDEPRFLAVGMIGARHWTAVYTYRSDRVRIISVRRARKQE
IDHYEGD

Nucleotide

• Length: 264 bp

>T76618 NZ_CP021431:129823-130086 [Yoonia vestfoldensis]
ATGAAGTTCGAGTATGACCCCGACAAGAGCACCGCGAACCGTGAAAAGCACGGGATCGACTTTGATGAGGCCCAGGCTCT
CTGGAATGATCCTTATCTGATCGAGGCCCCTGCCAACGTCACGGATGAGCCACGCTTTCTGGCGGTTGGCATGATCGGGG
CCAGACACTGGACGGCTGTCTACACATACCGGAGCGACCGGGTGCGGATCATCTCCGTGCGCCGCGCTCGCAAGCAGGAG
ATTGACCACTATGAAGGCGACTGA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 8260.46 Da
• Isoelectric Point: 7.0136

>AT76618 WP_066009074.1 NZ_CP021431:130073-130288 [Yoonia vestfoldensis]
MKATEFDERFDAGEDMSAHVDWTKARRLNVEAKRVNVDFPTWVVAGLDRQAQKLGITRQALIKMWIAERLE

Nucleotide

• Length: 216 bp

>AT76618 NZ_CP021431:130073-130288 [Yoonia vestfoldensis]
ATGAAGGCGACTGAATTCGACGAACGCTTCGACGCGGGCGAAGACATGTCCGCCCATGTCGATTGGACAAAGGCGCGCCG
CCTCAATGTCGAGGCAAAGCGGGTGAACGTGGATTTCCCGACCTGGGTCGTCGCCGGTCTGGACCGGCAGGCTCAGAAGC
TCGGCATCACCCGTCAGGCGCTGATCAAGATGTGGATCGCAGAACGCCTCGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A1Y5TQY4