Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 20495..21083 Replicon plasmid p11
Accession NZ_CP021429
Organism Acinetobacter pittii strain HUMV-6483

Toxin (Protein)


Gene name relE Uniprot ID N9CKJ9
Locus tag CCK83_RS20045 Protein ID WP_004647749.1
Coordinates 20495..20791 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CCK83_RS20050 Protein ID WP_006582118.1
Coordinates 20793..21083 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCK83_RS20025 16071..17087 - 1017 WP_000009386.1 zinc-dependent alcohol dehydrogenase family protein -
CCK83_RS20030 17077..18072 - 996 WP_006582121.1 zinc-dependent alcohol dehydrogenase family protein -
CCK83_RS20035 18296..19207 - 912 WP_006582120.1 LysR family transcriptional regulator -
CCK83_RS20040 19320..20330 + 1011 WP_006582119.1 NAD(P)-dependent alcohol dehydrogenase -
CCK83_RS20045 20495..20791 + 297 WP_004647749.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CCK83_RS20050 20793..21083 + 291 WP_006582118.1 putative addiction module antidote protein Antitoxin
CCK83_RS20060 21497..21919 - 423 WP_006582116.1 hypothetical protein -
CCK83_RS20070 22132..23457 + 1326 WP_016805832.1 ISNCY family transposase -
CCK83_RS20075 24043..24825 - 783 WP_006582115.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..112604 112604
- inside IScluster/Tn - - 22120..38320 16200


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-92)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11584.25 Da        Isoelectric Point: 5.8801

>T76615 WP_004647749.1 NZ_CP021429:20495-20791 [Acinetobacter pittii]
MIEIKRLPEFDEWLDGIKDNMTRIRLNRRLDKVQRGNWGDIKPLQDGVWEMREFFGSGWRMYYIQHGDVVIVMLGGGDKS
TQQQDIDRAVKLSKTLED

Download         Length: 297 bp

>T76615 NZ_CP021429:20495-20791 [Acinetobacter pittii]
ATGATTGAAATTAAACGTCTACCAGAATTTGATGAATGGTTGGATGGCATTAAAGACAATATGACCCGCATTCGCTTGAA
TCGCCGATTAGATAAGGTTCAACGCGGGAACTGGGGAGACATTAAACCTCTCCAAGATGGCGTTTGGGAAATGAGAGAAT
TCTTCGGTTCTGGATGGAGGATGTATTACATCCAACATGGTGACGTTGTGATTGTAATGCTTGGTGGTGGAGATAAATCA
ACTCAACAACAAGACATCGATCGTGCAGTCAAATTATCGAAAACGTTGGAGGACTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10549.20 Da        Isoelectric Point: 5.6088

>AT76615 WP_006582118.1 NZ_CP021429:20793-21083 [Acinetobacter pittii]
MVKVADLPSFDMAESLKTEEDIVMYLNMVLEDNDPAELAHALGVIAKARGMTQIAKEAGIGREALYKALRHDSAPRFDTI
NRVVNALGLKLTVQHT

Download         Length: 291 bp

>AT76615 NZ_CP021429:20793-21083 [Acinetobacter pittii]
ATGGTTAAAGTAGCTGATTTACCAAGTTTTGATATGGCTGAGTCACTCAAAACTGAAGAAGACATCGTGATGTATCTCAA
TATGGTTCTTGAAGATAATGATCCTGCTGAATTAGCTCATGCCCTTGGTGTCATTGCTAAAGCTAGAGGTATGACCCAAA
TTGCTAAAGAAGCAGGGATCGGACGTGAAGCACTTTATAAAGCACTTCGCCATGATTCAGCTCCGCGTTTTGATACTATC
AATCGTGTTGTGAATGCACTTGGCTTAAAATTAACAGTTCAGCATACATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References