Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 844394..845047 Replicon chromosome
Accession NZ_CP021428
Organism Acinetobacter pittii strain HUMV-6483

Toxin (Protein)


Gene name cptA Uniprot ID A0A009QSR1
Locus tag CCK83_RS03995 Protein ID WP_005067287.1
Coordinates 844394..844783 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A009HHW9
Locus tag CCK83_RS04000 Protein ID WP_002117064.1
Coordinates 844790..845047 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCK83_RS03980 839501..841696 - 2196 WP_005067292.1 TRAP transporter large permease subunit -
CCK83_RS03985 841876..842451 - 576 WP_005067290.1 rhombosortase -
CCK83_RS03990 842535..843623 - 1089 WP_087400164.1 hypothetical protein -
CCK83_RS03995 844394..844783 - 390 WP_005067287.1 hypothetical protein Toxin
CCK83_RS04000 844790..845047 - 258 WP_002117064.1 succinate dehydrogenase assembly factor 2 Antitoxin
CCK83_RS04005 845236..846408 + 1173 WP_032006490.1 acyl-CoA dehydrogenase family protein -
CCK83_RS04010 846459..847949 - 1491 WP_032006489.1 NAD(P)/FAD-dependent oxidoreductase -
CCK83_RS04015 848131..848508 - 378 WP_002049717.1 50S ribosomal protein L17 -
CCK83_RS04020 848527..849534 - 1008 WP_002116730.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15505.61 Da        Isoelectric Point: 8.7390

>T76611 WP_005067287.1 NZ_CP021428:c844783-844394 [Acinetobacter pittii]
MIKELNFELKYSRVSVIFQLFVGLGLAILLYQLLTPIWWLCAVILLFIGFIFFLKQAQISQIEYLDQKLWSVAYFSKKEI
YRGEITKIIDYQLFVVIYLEETPTNIAIVWFDQLPIQQWKRLKVLEKLY

Download         Length: 390 bp

>T76611 NZ_CP021428:c844783-844394 [Acinetobacter pittii]
TTGATAAAAGAATTAAATTTTGAGCTGAAATATAGCCGTGTCTCGGTAATATTTCAGCTTTTTGTTGGTTTGGGTTTAGC
AATTTTGCTTTATCAGTTATTAACGCCGATATGGTGGCTATGTGCTGTCATTCTTCTATTTATTGGTTTTATTTTCTTTC
TAAAGCAAGCTCAAATATCTCAAATTGAATATTTAGATCAAAAATTATGGTCGGTTGCATATTTTTCGAAAAAAGAAATT
TACCGTGGGGAAATTACTAAAATAATTGATTATCAGTTATTTGTGGTTATTTATCTTGAAGAAACTCCTACGAACATAGC
TATTGTTTGGTTCGATCAGCTTCCTATTCAGCAGTGGAAAAGATTAAAAGTTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10295.73 Da        Isoelectric Point: 4.4809

>AT76611 WP_002117064.1 NZ_CP021428:c845047-844790 [Acinetobacter pittii]
MSDEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVDQEDPDLLDWFMEVSEPPRTELREFIYKLK
QYVHG

Download         Length: 258 bp

>AT76611 NZ_CP021428:c845047-844790 [Acinetobacter pittii]
ATGTCTGACGAAATGACCTTGGAAGAACGTAAAGTAATTTATCGAGCACGCCGCGGCTTAAAAGAAATTGACGTCTATTT
TGACCCGTATGTAAAAAATTATTATTTAAAAGCTGATCCGGCTGAAAAAGCATTATTTGCAGAGTTGGTTGATCAAGAAG
ATCCAGATTTATTAGATTGGTTCATGGAAGTTTCTGAACCTCCACGTACTGAGTTACGTGAATTTATTTATAAACTAAAA
CAGTATGTGCATGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A009QSR1

Antitoxin

Source ID Structure
AlphaFold DB A0A009HHW9

References