Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 102484..103162 Replicon chromosome
Accession NZ_CP021428
Organism Acinetobacter pittii strain HUMV-6483

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CCK83_RS00470 Protein ID WP_057077657.1
Coordinates 102980..103162 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CCK83_RS00465 Protein ID WP_057077658.1
Coordinates 102484..102888 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCK83_RS00455 97596..101678 - 4083 WP_087399961.1 tape measure protein -
CCK83_RS00460 101803..102402 - 600 WP_031968591.1 hypothetical protein -
CCK83_RS00465 102484..102888 - 405 WP_057077658.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CCK83_RS00470 102980..103162 - 183 WP_057077657.1 type II toxin-antitoxin system HicA family toxin Toxin
CCK83_RS00480 103494..104027 - 534 WP_057077656.1 hypothetical protein -
CCK83_RS00485 104074..105003 - 930 WP_087399963.1 hypothetical protein -
CCK83_RS00490 105112..105324 - 213 WP_087399965.1 hypothetical protein -
CCK83_RS00495 105326..105724 - 399 WP_025469848.1 hypothetical protein -
CCK83_RS00500 105726..106094 - 369 WP_005070369.1 hypothetical protein -
CCK83_RS00505 106066..106470 - 405 WP_025469849.1 hypothetical protein -
CCK83_RS00510 106479..106847 - 369 WP_000524231.1 hypothetical protein -
CCK83_RS00515 106847..107224 - 378 WP_057090125.1 hypothetical protein -
CCK83_RS20795 107228..107509 - 282 WP_057090138.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 77217..131219 54002


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6682.84 Da        Isoelectric Point: 10.5523

>T76610 WP_057077657.1 NZ_CP021428:c103162-102980 [Acinetobacter pittii]
VKSLDLIKMIEADGWYEVRVTGSHHHFKHPTKKGLVTIPHPKKDLPSGTVKSILKQAGLN

Download         Length: 183 bp

>T76610 NZ_CP021428:c103162-102980 [Acinetobacter pittii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTACAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGGTTAGTAACAATCCCGCATCCTAAAAAGGATTTACCAAGCGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14720.74 Da        Isoelectric Point: 4.3819

>AT76610 WP_057077658.1 NZ_CP021428:c102888-102484 [Acinetobacter pittii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENIKEAISGHLEILAEDGEEIPEASELIKFIDDADYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT76610 NZ_CP021428:c102888-102484 [Acinetobacter pittii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACCGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGATACACTTGAAGAAGCTATTGAAAATATTAAAGAAGCTATTTCAGGTCATTTAGAAATCTTAGCTGAAG
ATGGAGAGGAAATTCCTGAAGCTTCAGAATTGATTAAATTTATAGATGATGCTGACTATAAGGGTATGATCTGGGCAGTG
ACCGAGGTTGATGTAAGCCGCTATCTAGGTAAGCCTGAAAAAATCAATGTTACTTTGCCAAGCCGATTAATTCGGAAGAT
TGATGATAATGTAGGTAAGGATAAAAGATTTAAAACCCGATCTGCATTTTTGGCCGCCGGTGCTGAAAAGCTACTACATG
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References