Detailed information of TA system TA076601

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 1127690..1128263
• Replicon: chromosome
• Accession: NZ_CP021399
• Organism: Bordetella hinzii strain TR-1212

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CBR69_RS05500
• Protein ID: WP_019372855.1
• Coordinates: 1127976..1128263 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: W5ISI7
• Locus tag: CBR69_RS05495
• Protein ID: WP_009618210.1
• Coordinates: 1127690..1127989 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CBR69_RS05465	1122777..1122995	+	219	WP_142096542.1	AlpA family transcriptional regulator	-
CBR69_RS05470	1123038..1123904	+	867	WP_095377261.1	ParA family protein	-
CBR69_RS05475	1123888..1124136	+	249	WP_142096545.1	type II toxin-antitoxin system HicA family toxin	-
CBR69_RS05480	1124129..1125787	+	1659	WP_142096548.1	ParB family protein	-
CBR69_RS05485	1125805..1126365	+	561	WP_142096553.1	DUF2857 domain-containing protein	-
CBR69_RS05490	1126368..1127564	+	1197	WP_142096556.1	hypothetical protein	-
CBR69_RS05495	1127690..1127989	+	300	WP_009618210.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CBR69_RS05500	1127976..1128263	+	288	WP_019372855.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CBR69_RS05505	1128292..1128483	+	192	WP_142096559.1	hypothetical protein	-
CBR69_RS05510	1128603..1129382	+	780	WP_142096562.1	TIGR03761 family integrating conjugative element protein	-
CBR69_RS05515	1129379..1129927	+	549	WP_142096565.1	DUF3158 family protein	-
CBR69_RS05520	1129924..1130307	+	384	WP_004362284.1	single-stranded DNA-binding protein	-
CBR69_RS05525	1130602..1132632	+	2031	WP_142096568.1	DNA topoisomerase III	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1118311..1129382	11071

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-58)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10840.43 Da
• Isoelectric Point: 8.4628

>T76601 WP_019372855.1 NZ_CP021399:1127976-1128263 [Bordetella hinzii]
VRVLEWREAARADLLAIVDYISDDNPDAAQRLKDDIEAKAAKLPERPKLYRPGRVAGTREMVVRSNYVVVYMEDARAVSI
LRVLHAAQQWPPARE

Nucleotide

• Length: 288 bp

>T76601 NZ_CP021399:1127976-1128263 [Bordetella hinzii]
GTGCGCGTACTTGAGTGGCGCGAAGCTGCCCGCGCCGACCTGCTGGCGATTGTTGACTACATCTCGGACGACAACCCCGA
TGCCGCGCAGCGGTTGAAGGACGACATCGAGGCCAAGGCCGCGAAGCTGCCGGAGCGCCCGAAGCTCTACCGGCCTGGCC
GCGTGGCCGGCACGCGGGAAATGGTCGTGCGCTCGAACTACGTGGTGGTCTACATGGAAGACGCTCGCGCGGTGTCCATC
CTGCGCGTGTTGCACGCCGCGCAGCAGTGGCCGCCGGCACGGGAGTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10816.46 Da
• Isoelectric Point: 8.6579

>AT76601 WP_009618210.1 NZ_CP021399:1127690-1127989 [Bordetella hinzii]
MAAQTSMLHIRVDDKLKADAAEKLAGVGLTVSDAVRILLTRVVKEGALPAGLTADPEAYDAWFRAKVQEALADTRPPVPH
QQVMDEAQALIDRKRRART

Nucleotide

• Length: 300 bp

>AT76601 NZ_CP021399:1127690-1127989 [Bordetella hinzii]
ATGGCCGCACAGACTTCGATGCTGCACATCCGTGTGGACGACAAGCTCAAGGCCGATGCTGCCGAGAAGCTCGCCGGGGT
CGGCCTCACCGTTTCGGACGCCGTACGCATCCTGCTGACCCGTGTGGTCAAGGAAGGCGCGCTGCCGGCTGGCCTCACGG
CCGACCCGGAGGCCTACGATGCCTGGTTCCGGGCGAAGGTCCAGGAGGCGCTGGCCGACACACGGCCGCCGGTGCCGCAC
CAGCAGGTCATGGACGAGGCGCAGGCCCTGATCGACAGGAAGCGGCGTGCGCGTACTTGA

Structures

Antitoxin

• AlphaFold DB: A0A5R9QE11