Detailed information of TA system TA076600

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 1188944..1189517
• Replicon: chromosome
• Accession: NZ_CP021398
• Organism: Bordetella hinzii strain 14-3425

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CBR71_RS06020
• Protein ID: WP_141984815.1
• Coordinates: 1189230..1189517 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: W5ISI7
• Locus tag: CBR71_RS06015
• Protein ID: WP_009618210.1
• Coordinates: 1188944..1189243 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CBR71_RS05985	1184041..1184259	+	219	WP_009461157.1	AlpA family transcriptional regulator	-
CBR71_RS05990	1184301..1185167	+	867	WP_087837841.1	ParA family protein	-
CBR71_RS05995	1185151..1185399	+	249	WP_141984812.1	type II toxin-antitoxin system HicA family toxin	-
CBR71_RS06000	1185392..1187050	+	1659	WP_141984813.1	ParB family protein	-
CBR71_RS06005	1187068..1187628	+	561	WP_029578160.1	DUF2857 domain-containing protein	-
CBR71_RS06010	1187632..1188816	+	1185	WP_141984814.1	hypothetical protein	-
CBR71_RS06015	1188944..1189243	+	300	WP_009618210.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CBR71_RS06020	1189230..1189517	+	288	WP_141984815.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CBR71_RS06025	1189546..1189737	+	192	WP_009618207.1	hypothetical protein	-
CBR71_RS06030	1189861..1190640	+	780	WP_141984816.1	TIGR03761 family integrating conjugative element protein	-
CBR71_RS06035	1190637..1191188	+	552	WP_141984817.1	DUF3158 family protein	-
CBR71_RS06040	1191185..1191568	+	384	WP_141984818.1	single-stranded DNA-binding protein	-
CBR71_RS06045	1191864..1193879	+	2016	WP_141984819.1	DNA topoisomerase III	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1177894..1234666	56772

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-58)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10842.45 Da
• Isoelectric Point: 7.0132

>T76600 WP_141984815.1 NZ_CP021398:1189230-1189517 [Bordetella hinzii]
VRVLEWREAARADLLAIVDYISDDNPDAAQRLKDDIEAKAAKLPERPKLYRPGRVAGTREMVVRANYVVVYMEDTRAVSI
LRVLHAAQQWPLAQE

Nucleotide

• Length: 288 bp

>T76600 NZ_CP021398:1189230-1189517 [Bordetella hinzii]
GTGCGCGTACTTGAGTGGCGGGAAGCCGCCCGCGCTGACCTGCTGGCGATTGTTGACTACATCTCGGACGACAACCCCGA
TGCCGCGCAGCGGTTGAAGGACGACATCGAGGCCAAGGCCGCGAAGCTGCCGGAGCGCCCGAAGCTCTACCGGCCTGGCC
GCGTGGCCGGCACGCGGGAGATGGTCGTGCGTGCGAACTACGTGGTGGTCTACATGGAGGACACCCGCGCGGTGTCCATC
CTGCGCGTGTTGCACGCCGCGCAGCAGTGGCCGCTGGCACAGGAGTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10816.46 Da
• Isoelectric Point: 8.6579

>AT76600 WP_009618210.1 NZ_CP021398:1188944-1189243 [Bordetella hinzii]
MAAQTSMLHIRVDDKLKADAAEKLAGVGLTVSDAVRILLTRVVKEGALPAGLTADPEAYDAWFRAKVQEALADTRPPVPH
QQVMDEAQALIDRKRRART

Nucleotide

• Length: 300 bp

>AT76600 NZ_CP021398:1188944-1189243 [Bordetella hinzii]
ATGGCCGCACAGACTTCGATGCTGCACATCCGTGTGGACGATAAGCTCAAGGCCGATGCCGCCGAGAAGCTCGCCGGGGT
CGGCCTCACCGTTTCGGACGCCGTGCGCATCCTGCTGACCCGTGTGGTCAAGGAAGGCGCGCTGCCGGCTGGCCTCACGG
CCGACCCGGAGGCCTACGATGCCTGGTTCCGGGCGAAGGTCCAGGAGGCGCTGGCCGACACACGGCCGCCGGTGCCGCAC
CAGCAGGTCATGGACGAGGCGCAGGCGCTGATCGACAGGAAGCGGCGTGCGCGTACTTGA

Structures

Antitoxin

• AlphaFold DB: A0A5R9QE11