Detailed information of TA system TA076599

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 4716050..4716606
• Replicon: chromosome
• Accession: NZ_CP021396
• Organism: Bordetella hinzii strain 4134

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: CBR67_RS22395
• Protein ID: WP_032978872.1
• Coordinates: 4716050..4716340 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CBR67_RS22400
• Protein ID: WP_032957511.1
• Coordinates: 4716328..4716606 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CBR67_RS22380	4714311..4715093	-	783	WP_032978897.1	DUF1837 domain-containing protein	-
CBR67_RS22385	4715319..4715777	-	459	WP_080700866.1	helix-turn-helix domain-containing protein	-
CBR67_RS22390	4715789..4716049	-	261	WP_032978875.1	hypothetical protein	-
CBR67_RS22395	4716050..4716340	-	291	WP_032978872.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CBR67_RS22400	4716328..4716606	-	279	WP_032957511.1	CopG family ribbon-helix-helix protein	Antitoxin
CBR67_RS22405	4716811..4717062	+	252	WP_032978869.1	hypothetical protein	-
CBR67_RS22410	4717185..4717916	+	732	WP_032978894.1	recombinase family protein	-
CBR67_RS24060	4717913..4718083	+	171	WP_155271649.1	hypothetical protein	-
CBR67_RS22415	4718115..4718450	-	336	Protein_4399	AAA family ATPase	-
CBR67_RS22420	4718453..4718623	-	171	Protein_4400	AlpA family phage regulatory protein	-
CBR67_RS22425	4718711..4719919	-	1209	WP_032957508.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4704785..4719919	15134

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10900.56 Da
• Isoelectric Point: 9.5041

>T76599 WP_032978872.1 NZ_CP021396:c4716340-4716050 [Bordetella hinzii]
VPRLIWTPPAVADVQRLYRFLAPKDADAAQRAVKAIRAGVKILAHQPRIGRPVEDMEPEFREWLIDFGNSGYVALYRFDG
ENIAILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T76599 NZ_CP021396:c4716340-4716050 [Bordetella hinzii]
GTGCCACGTCTGATCTGGACGCCGCCGGCGGTGGCTGATGTGCAGCGGCTCTATCGCTTCCTCGCGCCCAAGGATGCCGA
CGCGGCGCAACGCGCGGTGAAGGCGATCCGGGCCGGGGTCAAGATTCTGGCACATCAGCCACGCATCGGCCGCCCGGTCG
AGGACATGGAACCCGAGTTTCGGGAATGGCTGATCGACTTCGGCAACAGCGGCTATGTCGCCCTCTATCGCTTCGACGGG
GAGAACATCGCCATTCTTGCCGTTCGGCATCAGAAAGAAGCGGGGTATTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10801.20 Da
• Isoelectric Point: 6.0964

>AT76599 WP_032957511.1 NZ_CP021396:c4716606-4716328 [Bordetella hinzii]
MARATSIKLDDELKGRVQHLAEARRRTSHWIMREAIAQYVEREEKREAFKQDALRAWEEYQRTGLHLTLEEADAWLAKLE
AGEDAELPKCHV

Nucleotide

• Length: 279 bp

>AT76599 NZ_CP021396:c4716606-4716328 [Bordetella hinzii]
ATGGCAAGGGCAACATCCATCAAGCTCGATGACGAGCTGAAAGGGCGCGTCCAGCACCTGGCCGAAGCCCGCCGGCGCAC
GTCGCACTGGATCATGCGAGAAGCCATCGCGCAGTACGTCGAGCGCGAGGAAAAGCGCGAGGCGTTCAAACAGGATGCGC
TCCGCGCCTGGGAAGAGTATCAGCGCACCGGCCTGCATCTGACACTTGAGGAAGCCGACGCCTGGCTGGCGAAGCTAGAA
GCCGGCGAGGATGCGGAGCTGCCTAAGTGCCACGTCTGA