Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 4716050..4716606 Replicon chromosome
Accession NZ_CP021396
Organism Bordetella hinzii strain 4134

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag CBR67_RS22395 Protein ID WP_032978872.1
Coordinates 4716050..4716340 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CBR67_RS22400 Protein ID WP_032957511.1
Coordinates 4716328..4716606 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CBR67_RS22380 4714311..4715093 - 783 WP_032978897.1 DUF1837 domain-containing protein -
CBR67_RS22385 4715319..4715777 - 459 WP_080700866.1 helix-turn-helix domain-containing protein -
CBR67_RS22390 4715789..4716049 - 261 WP_032978875.1 hypothetical protein -
CBR67_RS22395 4716050..4716340 - 291 WP_032978872.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CBR67_RS22400 4716328..4716606 - 279 WP_032957511.1 CopG family ribbon-helix-helix protein Antitoxin
CBR67_RS22405 4716811..4717062 + 252 WP_032978869.1 hypothetical protein -
CBR67_RS22410 4717185..4717916 + 732 WP_032978894.1 recombinase family protein -
CBR67_RS24060 4717913..4718083 + 171 WP_155271649.1 hypothetical protein -
CBR67_RS22415 4718115..4718450 - 336 Protein_4399 AAA family ATPase -
CBR67_RS22420 4718453..4718623 - 171 Protein_4400 AlpA family phage regulatory protein -
CBR67_RS22425 4718711..4719919 - 1209 WP_032957508.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4704785..4719919 15134


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10900.56 Da        Isoelectric Point: 9.5041

>T76599 WP_032978872.1 NZ_CP021396:c4716340-4716050 [Bordetella hinzii]
VPRLIWTPPAVADVQRLYRFLAPKDADAAQRAVKAIRAGVKILAHQPRIGRPVEDMEPEFREWLIDFGNSGYVALYRFDG
ENIAILAVRHQKEAGY

Download         Length: 291 bp

>T76599 NZ_CP021396:c4716340-4716050 [Bordetella hinzii]
GTGCCACGTCTGATCTGGACGCCGCCGGCGGTGGCTGATGTGCAGCGGCTCTATCGCTTCCTCGCGCCCAAGGATGCCGA
CGCGGCGCAACGCGCGGTGAAGGCGATCCGGGCCGGGGTCAAGATTCTGGCACATCAGCCACGCATCGGCCGCCCGGTCG
AGGACATGGAACCCGAGTTTCGGGAATGGCTGATCGACTTCGGCAACAGCGGCTATGTCGCCCTCTATCGCTTCGACGGG
GAGAACATCGCCATTCTTGCCGTTCGGCATCAGAAAGAAGCGGGGTATTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10801.20 Da        Isoelectric Point: 6.0964

>AT76599 WP_032957511.1 NZ_CP021396:c4716606-4716328 [Bordetella hinzii]
MARATSIKLDDELKGRVQHLAEARRRTSHWIMREAIAQYVEREEKREAFKQDALRAWEEYQRTGLHLTLEEADAWLAKLE
AGEDAELPKCHV

Download         Length: 279 bp

>AT76599 NZ_CP021396:c4716606-4716328 [Bordetella hinzii]
ATGGCAAGGGCAACATCCATCAAGCTCGATGACGAGCTGAAAGGGCGCGTCCAGCACCTGGCCGAAGCCCGCCGGCGCAC
GTCGCACTGGATCATGCGAGAAGCCATCGCGCAGTACGTCGAGCGCGAGGAAAAGCGCGAGGCGTTCAAACAGGATGCGC
TCCGCGCCTGGGAAGAGTATCAGCGCACCGGCCTGCATCTGACACTTGAGGAAGCCGACGCCTGGCTGGCGAAGCTAGAA
GCCGGCGAGGATGCGGAGCTGCCTAAGTGCCACGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References