Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1296746..1297312 Replicon chromosome
Accession NZ_CP021393
Organism Bifidobacterium breve strain NRBB52

Toxin (Protein)


Gene name relE Uniprot ID A0A0L0LSZ1
Locus tag NRBB52_RS05970 Protein ID WP_050824876.1
Coordinates 1297019..1297312 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0L7C7C8
Locus tag NRBB52_RS05965 Protein ID WP_014483711.1
Coordinates 1296746..1297015 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NRBB52_RS05940 1292495..1293190 - 696 WP_050824880.1 response regulator transcription factor -
NRBB52_RS05945 1293316..1293831 + 516 WP_050824879.1 hypothetical protein -
NRBB52_RS05950 1293828..1294718 + 891 WP_007056280.1 hypothetical protein -
NRBB52_RS05955 1294715..1295395 + 681 WP_003829413.1 ABC transporter ATP-binding protein -
NRBB52_RS05960 1295392..1296561 + 1170 WP_050824877.1 ABC transporter permease -
NRBB52_RS05965 1296746..1297015 + 270 WP_014483711.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NRBB52_RS05970 1297019..1297312 + 294 WP_050824876.1 type II toxin-antitoxin system YafQ family toxin Toxin
NRBB52_RS10795 1297318..1297590 - 273 WP_157825602.1 hypothetical protein -
NRBB52_RS05980 1297980..1298558 + 579 WP_032743531.1 RNA polymerase sigma factor -
NRBB52_RS05985 1298565..1299392 + 828 WP_106641078.1 hypothetical protein -
NRBB52_RS05990 1299524..1300150 + 627 WP_012577737.1 hypothetical protein -
NRBB52_RS05995 1300147..1300929 + 783 WP_106641079.1 murein hydrolase transporter LrgB -
NRBB52_RS06000 1300982..1301857 + 876 WP_003829425.1 ABC transporter ATP-binding protein -
NRBB52_RS10920 1301956..1302021 + 66 Protein_1125 superoxide dismutase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1290725..1323390 32665


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-95)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-85)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11216.97 Da        Isoelectric Point: 10.1999

>T76594 WP_050824876.1 NZ_CP021393:1297019-1297312 [Bifidobacterium breve]
MLKPDYTAAFQRDIKKLKRKHTDLRPLKEVIRLVLEDTADSKEVLRRRHRAHTLTGDLNGVLECHIGNAGDRLLLWIRDD
GTAMFMRTGSHDELLGR

Download         Length: 294 bp

>T76594 NZ_CP021393:1297019-1297312 [Bifidobacterium breve]
ATGCTCAAACCGGATTACACAGCGGCATTCCAGCGAGATATCAAGAAACTCAAACGCAAGCACACTGATTTACGCCCGCT
GAAAGAAGTCATTCGTCTGGTTCTTGAGGACACGGCGGACTCCAAGGAAGTATTGAGGCGTAGGCATCGCGCCCACACAC
TTACCGGTGATTTAAACGGCGTACTGGAATGCCACATCGGCAATGCCGGCGACCGGCTGCTTCTATGGATTCGCGATGAT
GGTACCGCCATGTTCATGCGAACCGGCAGCCATGACGAACTGTTGGGCAGATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9860.17 Da        Isoelectric Point: 4.7872

>AT76594 WP_014483711.1 NZ_CP021393:1296746-1297015 [Bifidobacterium breve]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVRERRIPLNLSYTTVPPETMEALDEAKNRLADGKPRFNSA
DEMFDSLGI

Download         Length: 270 bp

>AT76594 NZ_CP021393:1296746-1297015 [Bifidobacterium breve]
GTGAGCATGGCATCCGTCACAGTCCGCGTGGATGCGGACACCAAGCAGAAAGCCGCAAACATAGCCGAGGATCTCGGTCT
GGACTTGTCTTCGGTCACCCGCGCCTTCTACAAGCAGATTGTCCGGGAGAGGCGCATTCCTCTAAACCTTTCCTATACGA
CCGTGCCGCCTGAAACCATGGAGGCCCTTGACGAGGCGAAAAACAGGCTCGCCGACGGCAAACCTCGTTTCAACAGTGCC
GATGAGATGTTCGATTCGTTGGGAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L0LSZ1

Antitoxin

Source ID Structure
AlphaFold DB A0A0L7C7C8

References