Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1209179..1209745 Replicon chromosome
Accession NZ_CP021392
Organism Bifidobacterium breve strain NRBB51

Toxin (Protein)


Gene name relE Uniprot ID S2ZEY8
Locus tag NRBB51_RS05405 Protein ID WP_014483710.1
Coordinates 1209452..1209745 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0L7C7C8
Locus tag NRBB51_RS05400 Protein ID WP_014483711.1
Coordinates 1209179..1209448 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NRBB51_RS05375 1204928..1205623 - 696 WP_003829410.1 response regulator transcription factor -
NRBB51_RS05380 1205749..1206264 + 516 WP_013140733.1 hypothetical protein -
NRBB51_RS05385 1206261..1207151 + 891 WP_003831809.1 hypothetical protein -
NRBB51_RS05390 1207148..1207828 + 681 WP_003829413.1 ABC transporter ATP-binding protein -
NRBB51_RS05395 1207825..1208994 + 1170 WP_051317546.1 ABC transporter permease -
NRBB51_RS05400 1209179..1209448 + 270 WP_014483711.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NRBB51_RS05405 1209452..1209745 + 294 WP_014483710.1 type II toxin-antitoxin system YafQ family toxin Toxin
NRBB51_RS05420 1210705..1212204 + 1500 WP_015439061.1 IS21 family transposase -
NRBB51_RS05425 1212201..1212980 + 780 WP_015439062.1 IS21-like element helper ATPase IstB -
NRBB51_RS05430 1213092..1213532 + 441 Protein_1002 sigma-70 family RNA polymerase sigma factor -
NRBB51_RS05435 1213566..1214393 + 828 WP_015438835.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1177818..1275807 97989
- flank IS/Tn - - 1212201..1212980 779


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-85)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11188.96 Da        Isoelectric Point: 9.7881

>T76591 WP_014483710.1 NZ_CP021392:1209452-1209745 [Bifidobacterium breve]
MLKPDYTAAFQRDIKKLKRKHADLRPLKEVIRLVLEDTADSKEVLRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELLGK

Download         Length: 294 bp

>T76591 NZ_CP021392:1209452-1209745 [Bifidobacterium breve]
ATGCTCAAACCGGATTACACAGCGGCATTCCAGCGAGATATCAAGAAACTCAAACGCAAGCACGCTGATTTACGCCCGCT
GAAAGAAGTCATTCGTCTGGTTCTTGAGGACACGGCGGACTCCAAGGAAGTATTGAGGCGTAGGCATCGCGCCCACACAC
TTACCGGTGATTTAAACGGCGTACTGGAATGCCACATCGGCAATGCCGGCGACTGGCTGCTTCTATGGATTCGCGATGAT
GGTACCGCCATGTTCATGCGAACCGGCAGCCATGACGAACTGTTGGGCAAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9860.17 Da        Isoelectric Point: 4.7872

>AT76591 WP_014483711.1 NZ_CP021392:1209179-1209448 [Bifidobacterium breve]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVRERRIPLNLSYTTVPPETMEALDEAKNRLADGKPRFNSA
DEMFDSLGI

Download         Length: 270 bp

>AT76591 NZ_CP021392:1209179-1209448 [Bifidobacterium breve]
GTGAGCATGGCATCCGTCACAGTCCGCGTGGATGCGGACACCAAGCAGAAAGCCGCAAACATAGCCGAGGATCTCGGTCT
GGACTTGTCTTCGGTCACCCGCGCCTTCTACAAGCAGATTGTCCGGGAGAGGCGCATTCCTCTAAACCTTTCCTATACGA
CCGTGCCGCCTGAAACCATGGAGGCCCTTGACGAGGCGAAAAACAGGCTCGCCGACGGCAAACCTCGTTTCAACAGTGCC
GATGAGATGTTCGATTCGTTGGGAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S2ZEY8

Antitoxin

Source ID Structure
AlphaFold DB A0A0L7C7C8

References