Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/PIN-DinJ
Location 1489675..1490555 Replicon chromosome
Accession NZ_CP021390
Organism Bifidobacterium breve strain DRBB26

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag DRBB26_RS06765 Protein ID WP_106628344.1
Coordinates 1489675..1490166 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag DRBB26_RS06770 Protein ID WP_106628345.1
Coordinates 1490163..1490555 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DRBB26_RS06750 1485700..1486290 - 591 WP_106628341.1 Ltp family lipoprotein -
DRBB26_RS06755 1486680..1487324 + 645 WP_106628342.1 GNAT family N-acetyltransferase -
DRBB26_RS06760 1487493..1489595 + 2103 WP_106628343.1 DUF262 domain-containing protein -
DRBB26_RS06765 1489675..1490166 - 492 WP_106628344.1 type II toxin-antitoxin system VapC family toxin Toxin
DRBB26_RS06770 1490163..1490555 - 393 WP_106628345.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DRBB26_RS06775 1490701..1493400 - 2700 WP_106628346.1 aconitate hydratase AcnA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-146)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-66)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18542.68 Da        Isoelectric Point: 5.3092

>T76585 WP_106628344.1 NZ_CP021390:c1490166-1489675 [Bifidobacterium breve]
MSRPKQVSILCDTNVLIYYMLCTPRFINDVVKLFELCIEREVKLSCASLSLKDVFYITPERFKERFMNDESTVVAANAKL
MLPEVAWLGISRLKELMTIVPIGAEECEVAQSLRHMHNDFEDDLIIAAAKQSGASYVVTYDKKLAKHFPEYCKTPAEIVS
ALE

Download         Length: 492 bp

>T76585 NZ_CP021390:c1490166-1489675 [Bifidobacterium breve]
ATGAGCCGGCCAAAGCAGGTGTCAATACTATGCGACACCAATGTCCTCATTTATTACATGCTCTGTACACCTCGATTCAT
CAATGATGTCGTGAAATTGTTCGAGCTATGCATTGAGCGAGAAGTAAAGCTGTCCTGTGCGTCGTTGTCGCTGAAGGACG
TGTTCTACATCACCCCGGAGCGATTCAAAGAGCGATTCATGAATGACGAGTCCACAGTCGTTGCGGCCAACGCCAAGCTG
ATGTTGCCGGAAGTGGCATGGTTGGGAATCAGCAGGCTCAAAGAGCTGATGACAATCGTGCCGATTGGAGCGGAGGAATG
CGAGGTGGCGCAGTCATTGCGTCACATGCATAACGATTTCGAGGATGACCTTATCATCGCCGCGGCGAAGCAATCCGGGG
CCTCATATGTGGTGACGTATGACAAAAAACTAGCCAAGCATTTTCCCGAATATTGCAAAACGCCGGCCGAAATCGTGTCG
GCGCTGGAATAG

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 15260.40 Da        Isoelectric Point: 5.7692

>AT76585 WP_106628345.1 NZ_CP021390:c1490555-1490163 [Bifidobacterium breve]
MTMVQMNVRIDAKLKNEVDEVLKDKGVSVSDAIRALWSYIADRKEMPVLETTAEEQAREAEKQRKLKLIRESAGYVHKEM
VKAGLISEDTDLMEGLTHKQLRDEAYDEQLKKYRHQSDYLRYLEKERDLS

Download         Length: 393 bp

>AT76585 NZ_CP021390:c1490555-1490163 [Bifidobacterium breve]
ATGACCATGGTCCAGATGAACGTTCGCATTGATGCGAAGCTGAAGAACGAAGTCGATGAGGTGCTCAAGGACAAAGGCGT
ATCGGTGAGCGATGCGATTCGTGCGTTGTGGTCATATATCGCCGACCGTAAGGAGATGCCGGTATTGGAGACGACCGCCG
AGGAGCAGGCCCGTGAGGCGGAAAAGCAACGCAAACTGAAACTGATCCGTGAAAGCGCTGGTTACGTGCACAAGGAAATG
GTCAAGGCCGGACTGATTTCCGAAGACACTGATCTTATGGAAGGGCTCACCCACAAGCAGCTCCGCGATGAGGCATACGA
CGAGCAGCTGAAGAAATACAGGCATCAGTCGGATTATCTGCGTTATCTGGAGAAGGAGCGTGATCTGTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References