Detailed information of TA system TA076584

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1347070..1347636
• Replicon: chromosome
• Accession: NZ_CP021390
• Organism: Bifidobacterium breve strain DRBB26

Toxin (Protein)

• Gene name: relE
• Uniprot ID: D4BPQ4
• Locus tag: DRBB26_RS06150
• Protein ID: WP_003829417.1
• Coordinates: 1347343..1347636 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0L7C7C8
• Locus tag: DRBB26_RS06145
• Protein ID: WP_014483711.1
• Coordinates: 1347070..1347339 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DRBB26_RS06120	1342819..1343514	-	696	WP_003829410.1	response regulator transcription factor	-
DRBB26_RS06125	1343640..1344155	+	516	WP_013140733.1	hypothetical protein	-
DRBB26_RS06130	1344152..1345042	+	891	WP_025262987.1	hypothetical protein	-
DRBB26_RS06135	1345039..1345719	+	681	WP_003829413.1	ABC transporter ATP-binding protein	-
DRBB26_RS06140	1345716..1346885	+	1170	WP_050755802.1	ABC transporter permease	-
DRBB26_RS06145	1347070..1347339	+	270	WP_014483711.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
DRBB26_RS06150	1347343..1347636	+	294	WP_003829417.1	type II toxin-antitoxin system YafQ family toxin	Toxin
DRBB26_RS06155	1347678..1347995	+	318	WP_106628304.1	hypothetical protein	-
DRBB26_RS06160	1348075..1348377	+	303	WP_003829440.1	DUF2089 family protein	-
DRBB26_RS06165	1348380..1348724	+	345	WP_106628305.1	hypothetical protein	-
DRBB26_RS06170	1348865..1349263	-	399	WP_143246189.1	transcriptional regulator	-
DRBB26_RS10965	1349297..1349791	-	495	WP_106628307.1	MerR family transcriptional regulator	-
DRBB26_RS06180	1350122..1351342	+	1221	WP_106628308.1	ATP-binding protein	-
DRBB26_RS06185	1351456..1352097	+	642	WP_106628309.1	moaA protein	-
DRBB26_RS10970	1352190..1352483	+	294	WP_012471870.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1328751..1354100	25349

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-95)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (3-85)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11188.92 Da
• Isoelectric Point: 9.8306

>T76584 WP_003829417.1 NZ_CP021390:1347343-1347636 [Bifidobacterium breve]
MLKPDYTAAFQRDIKKLKRKHADLRPLKEVIRLVLEDTADSKEALRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELLGR

Nucleotide

• Length: 294 bp

>T76584 NZ_CP021390:1347343-1347636 [Bifidobacterium breve]
ATGCTCAAACCGGATTACACAGCGGCATTCCAGCGAGATATCAAGAAACTCAAACGCAAGCACGCTGATTTACGCCCGCT
GAAAGAAGTCATTCGTCTGGTGCTTGAGGACACGGCGGACTCCAAGGAAGCATTGAGGCGTAGGCATCGCGCCCACACAC
TTACCGGTGATCTAAACGGCGTACTGGAATGCCACATCGGCAATGCCGGCGACTGGCTGCTTCTATGGATTCGCGATGAT
GGTACCGCCATGTTCATGCGAACCGGCAGCCATGACGAACTGTTGGGCAGATAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9860.17 Da
• Isoelectric Point: 4.7872

>AT76584 WP_014483711.1 NZ_CP021390:1347070-1347339 [Bifidobacterium breve]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVRERRIPLNLSYTTVPPETMEALDEAKNRLADGKPRFNSA
DEMFDSLGI

Nucleotide

• Length: 270 bp

>AT76584 NZ_CP021390:1347070-1347339 [Bifidobacterium breve]
GTGAGCATGGCATCCGTCACAGTCCGCGTGGATGCGGACACCAAGCAGAAAGCCGCAAACATAGCCGAGGATCTCGGTCT
GGACTTGTCTTCGGTCACCCGCGCCTTCTACAAGCAGATTGTCCGGGAGAGGCGCATTCCTCTAAACCTTTCCTATACGA
CCGTGCCGCCTGAAACCATGGAGGCCCTTGACGAGGCGAAAAACAGGCTCGCCGACGGCAAACCTCGTTTCAACAGTGCC
GATGAGATGTTCGATTCGTTGGGAATCTGA

Structures

Toxin

• AlphaFold DB: A0A0L7C7H2

Antitoxin

• AlphaFold DB: A0A0L7C7C8