Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1231065..1231631 Replicon chromosome
Accession NZ_CP021386
Organism Bifidobacterium breve strain NRBB04

Toxin (Protein)


Gene name relE Uniprot ID A0A0L7AXF3
Locus tag NRBB04_RS05485 Protein ID WP_025262990.1
Coordinates 1231338..1231631 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0L7AY16
Locus tag NRBB04_RS05480 Protein ID WP_025262989.1
Coordinates 1231065..1231334 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NRBB04_RS05455 1226814..1227509 - 696 WP_003829410.1 response regulator transcription factor -
NRBB04_RS05460 1227635..1228150 + 516 WP_013140733.1 hypothetical protein -
NRBB04_RS05465 1228147..1229037 + 891 WP_025262987.1 hypothetical protein -
NRBB04_RS05470 1229034..1229714 + 681 WP_003829413.1 ABC transporter ATP-binding protein -
NRBB04_RS05475 1229711..1230880 + 1170 WP_025262988.1 ABC transporter permease -
NRBB04_RS05480 1231065..1231334 + 270 WP_025262989.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NRBB04_RS05485 1231338..1231631 + 294 WP_025262990.1 type II toxin-antitoxin system YafQ family toxin Toxin
NRBB04_RS10340 1231637..1231936 - 300 WP_025262991.1 hypothetical protein -
NRBB04_RS05495 1232299..1232849 + 551 Protein_1017 RNA polymerase sigma factor -
NRBB04_RS05500 1232883..1233710 + 828 WP_015438835.1 hypothetical protein -
NRBB04_RS05505 1233842..1234468 + 627 WP_025262993.1 hypothetical protein -
NRBB04_RS05510 1234465..1235247 + 783 WP_025262994.1 hypothetical protein -
NRBB04_RS05515 1235300..1236175 + 876 WP_021649674.1 ABC transporter ATP-binding protein -
NRBB04_RS05520 1236230..1236628 + 399 WP_015438839.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1224970..1250485 25515


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-95)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-87)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11190.93 Da        Isoelectric Point: 9.7881

>T76575 WP_025262990.1 NZ_CP021386:1231338-1231631 [Bifidobacterium breve]
MLKPDYTAAFQRDIKKLKRKHTDLRPLKEVIRLVLEDTADSKEALRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELLGK

Download         Length: 294 bp

>T76575 NZ_CP021386:1231338-1231631 [Bifidobacterium breve]
ATGCTCAAACCGGATTACACGGCGGCATTCCAGCGAGATATCAAGAAACTCAAACGCAAGCACACTGATTTACGCCCGCT
GAAAGAAGTCATTCGTCTGGTGCTTGAGGACACGGCGGACTCCAAGGAAGCATTGAGGCGTAGGCATCGAGCCCACACAC
TTACCGGTGATCTAAACGGCGTACTGGAATGCCACATCGGCAATGCCGGCGACTGGCTGCTTCTATGGATTCGCGATGAT
GGTACCGCCATGTTCATGCGAACCGGCAGCCATGACGAACTGTTGGGCAAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9860.12 Da        Isoelectric Point: 4.5742

>AT76575 WP_025262989.1 NZ_CP021386:1231065-1231334 [Bifidobacterium breve]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVRERRIPLNLSYTTVPPETMEALDEAKNRLADGQPRFNSA
DEMFDSLGI

Download         Length: 270 bp

>AT76575 NZ_CP021386:1231065-1231334 [Bifidobacterium breve]
GTGAGCATGGCATCCGTCACAGTCCGCGTGGATGCGGACACCAAGCAGAAAGCCGCAAACATAGCCGAGGATCTCGGTCT
GGACTTGTCTTCGGTCACCCGCGCCTTCTACAAGCAGATTGTCCGGGAGAGGCGCATTCCCCTAAACCTTTCCTATACGA
CCGTGCCGCCTGAAACCATGGAGGCCCTTGACGAGGCGAAGAACAGGCTCGCCGACGGCCAACCTCGCTTCAACAGTGCC
GATGAGATGTTCGATTCGTTGGGAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L7AXF3

Antitoxin

Source ID Structure
AlphaFold DB A0A0L7AY16

References