Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1202957..1203523 Replicon chromosome
Accession NZ_CP021384
Organism Bifidobacterium breve strain NRBB01

Toxin (Protein)


Gene name relE Uniprot ID D4BPQ4
Locus tag NRBB01_RS05425 Protein ID WP_003829417.1
Coordinates 1203230..1203523 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0L7C7C8
Locus tag NRBB01_RS05420 Protein ID WP_014483711.1
Coordinates 1202957..1203226 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NRBB01_RS05395 1198706..1199401 - 696 WP_003829410.1 response regulator transcription factor -
NRBB01_RS05400 1199527..1200042 + 516 WP_013140733.1 hypothetical protein -
NRBB01_RS05405 1200039..1200929 + 891 WP_003829412.1 hypothetical protein -
NRBB01_RS05410 1200926..1201606 + 681 WP_003829413.1 ABC transporter ATP-binding protein -
NRBB01_RS05415 1201603..1202772 + 1170 WP_050755802.1 ABC transporter permease -
NRBB01_RS05420 1202957..1203226 + 270 WP_014483711.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NRBB01_RS05425 1203230..1203523 + 294 WP_003829417.1 type II toxin-antitoxin system YafQ family toxin Toxin
NRBB01_RS10335 1203529..1203828 - 300 WP_003829418.1 hypothetical protein -
NRBB01_RS05435 1204191..1204742 + 552 WP_050755804.1 RNA polymerase sigma factor -
NRBB01_RS05440 1204776..1205603 + 828 WP_003829422.1 hypothetical protein -
NRBB01_RS05445 1205736..1206362 + 627 WP_003829423.1 hypothetical protein -
NRBB01_RS05450 1206359..1207141 + 783 WP_003829424.1 hypothetical protein -
NRBB01_RS05455 1207194..1208069 + 876 WP_003829425.1 ABC transporter ATP-binding protein -
NRBB01_RS05460 1208123..1208521 + 399 WP_003829426.1 superoxide dismutase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1196859..1222392 25533


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-95)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-85)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11188.92 Da        Isoelectric Point: 9.8306

>T76570 WP_003829417.1 NZ_CP021384:1203230-1203523 [Bifidobacterium breve]
MLKPDYTAAFQRDIKKLKRKHADLRPLKEVIRLVLEDTADSKEALRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELLGR

Download         Length: 294 bp

>T76570 NZ_CP021384:1203230-1203523 [Bifidobacterium breve]
ATGCTCAAACCGGATTACACAGCGGCATTCCAGCGAGATATCAAGAAACTCAAACGCAAGCACGCTGATTTACGCCCGCT
GAAAGAAGTCATTCGTCTGGTGCTTGAGGACACGGCGGACTCCAAGGAAGCATTGAGGCGTAGGCATCGCGCCCACACAC
TTACCGGTGATCTAAACGGCGTACTGGAATGCCACATCGGCAATGCCGGCGACTGGCTGCTTCTATGGATTCGCGATGAT
GGTACCGCCATGTTCATGCGAACCGGCAGCCATGACGAACTGTTGGGCAGATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9860.17 Da        Isoelectric Point: 4.7872

>AT76570 WP_014483711.1 NZ_CP021384:1202957-1203226 [Bifidobacterium breve]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVRERRIPLNLSYTTVPPETMEALDEAKNRLADGKPRFNSA
DEMFDSLGI

Download         Length: 270 bp

>AT76570 NZ_CP021384:1202957-1203226 [Bifidobacterium breve]
GTGAGCATGGCATCCGTCACAGTCCGCGTGGATGCGGACACCAAGCAGAAAGCCGCAAACATAGCCGAGGATCTCGGTCT
GGACTTGTCTTCGGTCACCCGCGCCTTCTACAAGCAGATTGTCCGGGAGAGGCGCATTCCTCTAAACCTTTCCTATACGA
CCGTGCCGCCTGAAACCATGGAGGCCCTTGACGAGGCGAAAAACAGGCTCGCCGACGGCAAACCTCGTTTCAACAGTGCC
GATGAGATGTTCGATTCGTTGGGAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L7C7H2

Antitoxin

Source ID Structure
AlphaFold DB A0A0L7C7C8

References