Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1893162..1893838 Replicon chromosome
Accession NZ_CP021383
Organism Cellulosimicrobium cellulans strain PSBB019

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CBR64_RS08165 Protein ID WP_087470494.1
Coordinates 1893428..1893838 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CBR64_RS08160 Protein ID WP_087470493.1
Coordinates 1893162..1893431 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CBR64_RS08135 1888632..1889009 + 378 WP_087470489.1 glycine cleavage system protein GcvH -
CBR64_RS08140 1889296..1889550 + 255 WP_087470490.1 helix-turn-helix transcriptional regulator -
CBR64_RS08145 1889630..1890058 + 429 WP_087470491.1 (deoxy)nucleoside triphosphate pyrophosphohydrolase -
CBR64_RS08150 1890102..1890641 - 540 WP_208863474.1 AAA family ATPase -
CBR64_RS08155 1890785..1892875 - 2091 WP_087470492.1 right-handed parallel beta-helix repeat-containing protein -
CBR64_RS08160 1893162..1893431 + 270 WP_087470493.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CBR64_RS08165 1893428..1893838 + 411 WP_087470494.1 type II toxin-antitoxin system VapC family toxin Toxin
CBR64_RS08170 1893931..1895784 + 1854 WP_087470495.1 DUF308 domain-containing protein -
CBR64_RS08175 1895792..1897081 - 1290 WP_087470496.1 starvation-sensing protein RspA -
CBR64_RS08180 1897078..1897947 - 870 WP_087470497.1 NAD(P)-dependent oxidoreductase -
CBR64_RS08185 1897968..1898360 - 393 WP_087470498.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(1-88)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14757.69 Da        Isoelectric Point: 4.6455

>T76567 WP_087470494.1 NZ_CP021383:1893428-1893838 [Cellulosimicrobium cellulans]
VIVDTSALVAIVLDEPGADTLSEILLAASRPRMASPTLVELYAVLDNRSSPAQRRRLDALLELYGIEVEPFTAEHAEIAR
EAYREFGRGSGHPARLNLGDCFAYALAAATRDRLLFVGDDFARTDLRPAHEAAPPA

Download         Length: 411 bp

>T76567 NZ_CP021383:1893428-1893838 [Cellulosimicrobium cellulans]
GTGATCGTCGACACGTCCGCGCTCGTCGCCATCGTCCTGGACGAGCCGGGCGCCGACACGCTCTCCGAGATCCTGCTCGC
GGCCAGCCGTCCGCGCATGGCCTCCCCGACCCTCGTCGAGCTCTACGCCGTCCTGGACAACCGGTCGTCCCCGGCGCAGC
GCCGCCGGCTCGACGCCCTCCTCGAGCTCTACGGGATCGAGGTCGAGCCGTTCACGGCCGAGCACGCCGAGATCGCCCGC
GAGGCGTACCGCGAGTTCGGCCGGGGGAGCGGGCACCCGGCGCGCCTGAACCTCGGCGACTGCTTCGCGTACGCGCTGGC
CGCCGCGACGCGCGACCGGCTCCTCTTCGTGGGCGACGACTTCGCGCGCACCGACCTGCGCCCCGCGCACGAGGCCGCAC
CGCCGGCCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9947.05 Da        Isoelectric Point: 4.7370

>AT76567 WP_087470493.1 NZ_CP021383:1893162-1893431 [Cellulosimicrobium cellulans]
MSLNIKNERTHALVRRLAETTGQSQTSAIEDAVQRRLDEVLESRSRGDEAVAARRAEIARLLDEIRVDLDVESVRAAEAS
LYDESGLPR

Download         Length: 270 bp

>AT76567 NZ_CP021383:1893162-1893431 [Cellulosimicrobium cellulans]
ATGAGCCTCAACATCAAGAACGAGCGCACGCACGCGCTCGTGCGCCGGCTCGCGGAGACCACGGGCCAGTCGCAGACGAG
CGCGATCGAGGACGCGGTCCAGCGCCGTCTCGACGAGGTGCTCGAGTCCCGGTCGAGGGGCGACGAGGCCGTCGCCGCCC
GACGCGCCGAGATCGCCCGGCTCCTCGACGAGATCCGCGTCGACCTCGACGTCGAGAGCGTGCGTGCCGCGGAGGCGTCG
CTCTACGACGAGAGCGGTCTCCCTCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References