Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 978220..978872 Replicon chromosome
Accession NZ_CP021383
Organism Cellulosimicrobium cellulans strain PSBB019

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CBR64_RS04155 Protein ID WP_087469862.1
Coordinates 978450..978872 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CBR64_RS04150 Protein ID WP_087469861.1
Coordinates 978220..978453 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CBR64_RS04135 975227..975781 - 555 WP_047233909.1 hypoxanthine phosphoribosyltransferase -
CBR64_RS04140 975787..976935 - 1149 WP_087469860.1 tRNA lysidine(34) synthetase TilS -
CBR64_RS04145 976940..978079 - 1140 WP_087472532.1 zinc-dependent metalloprotease -
CBR64_RS04150 978220..978453 + 234 WP_087469861.1 antitoxin Antitoxin
CBR64_RS04155 978450..978872 + 423 WP_087469862.1 type II toxin-antitoxin system VapC family toxin Toxin
CBR64_RS04160 978883..980295 - 1413 WP_087472533.1 D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase -
CBR64_RS04165 980551..981054 + 504 WP_087469863.1 inorganic diphosphatase -
CBR64_RS04170 981125..983095 - 1971 WP_167551006.1 cell wall-binding repeat-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15199.23 Da        Isoelectric Point: 4.9650

>T76566 WP_087469862.1 NZ_CP021383:978450-978872 [Cellulosimicrobium cellulans]
VSTLYLLDTHVLVALLRGNGSSARPRLREAEGRVAVSTVSEMELEYGIERSSDPHRNRQAVDELLSLVDVLPFDGLAAMH
AGRVRALLAARGTPIGPYDALLAGHARSLGLVMVTNNVREFSRVPGLEVEDWLTEASDEP

Download         Length: 423 bp

>T76566 NZ_CP021383:978450-978872 [Cellulosimicrobium cellulans]
GTGAGCACGCTCTACCTGCTGGACACCCACGTCCTCGTGGCGCTGCTCCGCGGGAACGGCTCGTCGGCGCGCCCGAGGCT
GCGGGAGGCGGAGGGGCGCGTCGCGGTCTCGACGGTGAGCGAGATGGAGCTCGAGTACGGCATCGAGAGGTCTAGCGACC
CGCATCGCAACCGTCAGGCCGTCGACGAGCTGCTGTCTCTCGTGGACGTGCTCCCCTTCGACGGTCTCGCGGCGATGCAC
GCCGGACGCGTCCGCGCCCTCCTCGCCGCCCGCGGCACGCCCATCGGGCCCTACGACGCCCTCCTCGCCGGGCACGCCCG
GTCGCTCGGTCTCGTCATGGTGACGAACAACGTCCGCGAGTTCTCCCGCGTCCCCGGTCTCGAGGTCGAGGACTGGCTCA
CGGAAGCATCAGACGAACCGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8657.70 Da        Isoelectric Point: 7.2053

>AT76566 WP_087469861.1 NZ_CP021383:978220-978453 [Cellulosimicrobium cellulans]
MVRTTVFRSNRTQAVRLPKAVALPDDVREVEVRAVGRSRVITPAGSGWDEWFDHGLRTAAHFLPDRDQGTAEERDAL

Download         Length: 234 bp

>AT76566 NZ_CP021383:978220-978453 [Cellulosimicrobium cellulans]
ATGGTCCGCACGACGGTGTTCCGCAGCAACCGGACGCAGGCGGTCCGCCTGCCCAAGGCGGTCGCGCTGCCCGACGACGT
CCGGGAGGTGGAGGTCCGGGCCGTCGGCAGGTCCCGAGTGATCACGCCGGCAGGATCCGGGTGGGACGAGTGGTTCGACC
ACGGTCTCCGCACCGCCGCTCACTTCCTCCCCGACCGTGACCAGGGGACCGCCGAGGAGCGCGACGCGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References