76563

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5162001..5162609 Replicon chromosome
Accession NZ_CP021380
Organism Pseudomonas aeruginosa strain CCBH4851

Toxin (Protein)


Gene name PfiT Uniprot ID -
Locus tag JG10_RS24430 Protein ID WP_016263850.1
Coordinates 5162001..5162348 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag JG10_RS24435 Protein ID WP_003114155.1
Coordinates 5162358..5162609 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG10_RS24400 5157360..5157632 + 273 WP_019725834.1 cysteine-rich CWC family protein -
JG10_RS24405 5157632..5158324 + 693 WP_003098362.1 16S rRNA pseudouridine(516) synthase -
JG10_RS24410 5158460..5159503 + 1044 WP_003098363.1 L,D-transpeptidase -
JG10_RS24415 5159583..5160320 + 738 WP_003114158.1 murein L,D-transpeptidase catalytic domain family protein -
JG10_RS24420 5160772..5161674 + 903 WP_003123042.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
JG10_RS24430 5162001..5162348 - 348 WP_016263850.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JG10_RS24435 5162358..5162609 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JG10_RS24440 5162823..5163806 - 984 WP_019725833.1 tyrosine-type recombinase/integrase -
JG10_RS24445 5163806..5165098 - 1293 WP_003115206.1 hypothetical protein -
JG10_RS24450 5165357..5166619 - 1263 WP_019725831.1 hypothetical protein -
JG10_RS24455 5166621..5166971 - 351 WP_019725830.1 DUF2523 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage catB7 - 5162001..5184144 22143


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-100)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 116 a.a.        Molecular weight: 13046.85 Da        Isoelectric Point: 4.4212

>T76563 WP_016263850.1 NZ_CP021380:c5162348-5162001 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLVPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEVAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T76563 NZ_CP021380:c5162348-5162001 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGTTCCATTCCA
AGGTGAACAGGCTGCATTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGTGGCAGTGATCTTGGTTTTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT76563 WP_003114155.1 NZ_CP021380:c5162609-5162358 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT76563 NZ_CP021380:c5162609-5162358 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACTTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References