76558

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 148470..148975 Replicon chromosome
Accession NZ_CP021380
Organism Pseudomonas aeruginosa strain CCBH4851

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag JG10_RS00665 Protein ID WP_003083773.1
Coordinates 148470..148751 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag JG10_RS00670 Protein ID WP_003083775.1
Coordinates 148748..148975 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG10_RS00640 143721..145070 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
JG10_RS00645 145119..145805 + 687 WP_003083762.1 FadR family transcriptional regulator -
JG10_RS00650 145906..146640 + 735 WP_003117208.1 GntR family transcriptional regulator -
JG10_RS00655 146844..147230 + 387 WP_014602345.1 aegerolysin family protein -
JG10_RS00660 147262..148170 - 909 WP_003083769.1 LysR family transcriptional regulator -
JG10_RS00665 148470..148751 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
JG10_RS00670 148748..148975 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
JG10_RS00675 149151..149771 - 621 WP_009314940.1 hypothetical protein -
JG10_RS00680 149872..150372 + 501 WP_003112629.1 LEA type 2 family protein -
JG10_RS00685 150445..150786 + 342 WP_003101229.1 alkylphosphonate utilization protein -
JG10_RS00690 150868..152295 - 1428 WP_003083784.1 GABA permease -
JG10_RS00695 152464..153957 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T76558 WP_003083773.1 NZ_CP021380:c148751-148470 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T76558 NZ_CP021380:c148751-148470 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT76558 WP_003083775.1 NZ_CP021380:c148975-148748 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT76558 NZ_CP021380:c148975-148748 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References