Detailed information of TA system TA076556

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 2856860..2857334
• Replicon: chromosome
• Accession: NZ_CP021377
• Organism: Oceanisphaera profunda strain SM1222

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: CBP31_RS12645
• Protein ID: WP_174664634.1
• Coordinates: 2856860..2857123 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: CBP31_RS12650
• Protein ID: WP_087037838.1
• Coordinates: 2857107..2857334 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CBP31_RS12635	2853320..2854570	+	1251	WP_087037829.1	flagellar hook-associated protein FlgL	-
CBP31_RS12640	2855692..2856210	+	519	WP_087037832.1	hypothetical protein	-
CBP31_RS12645	2856860..2857123	-	264	WP_174664634.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CBP31_RS12650	2857107..2857334	-	228	WP_087037838.1	ribbon-helix-helix protein, CopG family	Antitoxin
CBP31_RS12655	2858308..2859468	-	1161	WP_169712999.1	type II toxin-antitoxin system HipA family toxin	-
CBP31_RS12660	2859458..2859700	-	243	WP_087037840.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10192.89 Da
• Isoelectric Point: 10.4335

>T76556 WP_174664634.1 NZ_CP021377:c2857123-2856860 [Oceanisphaera profunda]
MVWTVELTSSAKKQLAKIGHTEAQRITKYLRRIMVLADPRTTGKALTGNLREYWRYRVGDYRVICEIRDTELVIVAVTIG
HRRDIYQ

Nucleotide

• Length: 264 bp

>T76556 NZ_CP021377:c2857123-2856860 [Oceanisphaera profunda]
TTGGTTTGGACAGTTGAACTTACCAGTTCCGCTAAAAAGCAGTTGGCTAAAATAGGCCATACTGAAGCACAGCGAATTAC
TAAGTATCTACGACGGATAATGGTGCTAGCCGACCCTCGAACTACAGGGAAAGCGTTAACCGGTAACCTGCGTGAATATT
GGCGTTATAGAGTGGGTGATTATAGAGTCATTTGTGAAATCAGAGATACGGAGTTAGTTATTGTAGCTGTTACGATTGGT
CATCGTAGAGATATTTATCAATGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8754.80 Da
• Isoelectric Point: 4.1319

>AT76556 WP_087037838.1 NZ_CP021377:c2857334-2857107 [Oceanisphaera profunda]
MSTSIRLPKDIELRLNQLALETGRSKSFYLRELIENGLDDLEDYYLADSVMERVRQGKEELYSLDDVERELGLDS

Nucleotide

• Length: 228 bp

>AT76556 NZ_CP021377:c2857334-2857107 [Oceanisphaera profunda]
ATGTCAACTTCAATTAGGTTGCCTAAAGACATTGAGTTACGTCTTAACCAGTTAGCATTAGAAACTGGACGTTCAAAGTC
ATTCTACTTGCGTGAGCTTATAGAAAATGGGCTTGATGACTTGGAAGATTACTACTTAGCCGACAGCGTGATGGAGCGAG
TTCGCCAAGGTAAAGAAGAGCTTTATTCTTTAGATGATGTGGAGCGTGAACTTGGTTTGGACAGTTGA