76548

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 79627..81154 Replicon plasmid pACP4.2
Accession NZ_CP021368
Organism Acidovorax carolinensis strain P4

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag CBP36_RS20590 Protein ID WP_086929087.1
Coordinates 79877..81154 (+) Length 426 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag CBP36_RS20585 Protein ID WP_086929086.1
Coordinates 79627..79887 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CBP36_RS20560 74955..76040 - 1086 WP_086929084.1 IS630 family transposase -
CBP36_RS20565 76119..76736 - 618 Protein_66 IS5 family transposase -
CBP36_RS20570 77047..78117 + 1071 WP_157896847.1 site-specific integrase -
CBP36_RS20580 78533..79048 + 516 Protein_68 hypothetical protein -
CBP36_RS20585 79627..79887 + 261 WP_086929086.1 helix-turn-helix transcriptional regulator Antitoxin
CBP36_RS20590 79877..81154 + 1278 WP_086929087.1 type II toxin-antitoxin system HipA family toxin Toxin
CBP36_RS20595 81340..81792 + 453 WP_086929088.1 hypothetical protein -
CBP36_RS20600 82564..83610 + 1047 Protein_72 IS30 family transposase -
CBP36_RS20605 83629..84192 - 564 WP_143218421.1 hypothetical protein -
CBP36_RS22390 84656..84913 - 258 WP_157896848.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - sodB 1..163888 163888


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 426 a.a.        Molecular weight: 47103.21 Da        Isoelectric Point: 6.7158

>T76548 WP_086929087.1 NZ_CP021368:79877-81154 [Acidovorax carolinensis]
MVHELEVWVFADRVGTLALVDGRLNFCYLPDWLSHKDAITLSASLPLQAEPFDDRKTRPFFAGLLPEGQMRRLIAKQFQV
SGQNDFALLDHIGGECAGAVTFLEPGQALPVPTRSDDVQWLSDEEVVAILDELPRRPMLAGQDGLRLSLAGAQDKLPVVF
DGARIGLPLNGTPSSHILKPAIHAVEDSVSNEGFCMALAEAMQLKPAKSKVHKVLDCSFLLVERYDRLIDAQGNRQRLHQ
EDFCQALGVVPEMKYQNEGGPDLAQCFDLLRSATRPSAPQVLRLLDYVIFNALIGNHDAHAKNFSLLYSGKAPVLAPSYD
MLSTAVYPTLTQNMAMKIGSKYKFSEVQARHWEQFAESVGLTKAQAKRRILELAKLLPANARKLQFAPERGFVKNDVVEQ
ISTLIEHRCALTIRRLNVPATESSV

Download         Length: 1278 bp

>T76548 NZ_CP021368:79877-81154 [Acidovorax carolinensis]
ATGGTGCATGAACTGGAAGTCTGGGTTTTTGCAGATCGTGTCGGCACGTTGGCGCTGGTTGATGGTCGACTCAACTTTTG
CTACCTACCCGATTGGCTGTCACACAAGGACGCCATCACCTTGTCTGCCTCGCTGCCCCTGCAAGCGGAGCCGTTCGACG
ATCGCAAAACGCGCCCCTTCTTTGCGGGTCTTCTGCCCGAAGGGCAGATGCGCCGCTTGATTGCGAAACAATTCCAAGTT
TCAGGCCAGAACGACTTTGCACTGCTGGACCACATTGGCGGCGAATGCGCCGGGGCTGTGACGTTCCTAGAGCCGGGACA
AGCTTTGCCTGTGCCGACCCGTAGCGATGACGTTCAATGGCTGAGCGACGAGGAAGTTGTTGCCATCCTGGATGAACTAC
CGCGCCGCCCCATGTTGGCAGGCCAAGACGGCTTGCGGCTTTCATTGGCAGGTGCCCAGGACAAACTACCGGTGGTGTTT
GACGGTGCCCGCATTGGTCTGCCCCTCAACGGAACGCCTAGCTCGCATATCCTGAAACCGGCCATTCACGCTGTTGAAGA
CAGCGTTAGCAACGAGGGATTCTGCATGGCACTGGCTGAGGCCATGCAGCTCAAGCCAGCGAAATCAAAAGTACACAAGG
TATTGGATTGCTCCTTTCTGCTGGTTGAACGCTACGACCGACTGATTGATGCGCAGGGGAACCGTCAACGCCTTCATCAA
GAGGATTTCTGCCAGGCGCTGGGTGTGGTGCCAGAAATGAAATACCAAAATGAAGGTGGTCCGGATCTGGCGCAGTGCTT
TGATCTGTTACGCAGTGCGACACGCCCCAGTGCACCGCAGGTTCTGCGACTGCTCGACTATGTGATCTTCAATGCGCTGA
TCGGCAATCATGATGCGCACGCCAAGAATTTCTCACTGCTGTACTCGGGCAAGGCGCCCGTTCTGGCACCGTCTTACGAC
ATGCTCTCGACGGCAGTGTATCCAACACTGACGCAAAATATGGCGATGAAAATCGGCAGCAAGTACAAGTTCAGCGAAGT
CCAGGCGCGTCACTGGGAGCAGTTTGCTGAAAGCGTCGGGCTAACCAAAGCGCAGGCCAAACGGCGAATTCTGGAGCTTG
CAAAGTTACTGCCAGCGAATGCACGCAAGCTTCAGTTTGCCCCTGAACGAGGTTTTGTGAAGAATGACGTGGTAGAGCAA
ATCAGTACCTTGATAGAACACCGCTGCGCACTGACGATTCGGCGGCTCAACGTCCCCGCCACCGAATCCTCTGTCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 8987.31 Da        Isoelectric Point: 5.7527

>AT76548 WP_086929086.1 NZ_CP021368:79627-79887 [Acidovorax carolinensis]
MTSIRSPQQLGDALRAARKQLGLTQPQLALAAGVGVRFIVELEAGKPTLRLENVLRVIDALGGEIQLSGLPSTVVDDQCE
GGNHGA

Download         Length: 261 bp

>AT76548 NZ_CP021368:79627-79887 [Acidovorax carolinensis]
ATGACATCCATTCGATCCCCGCAACAACTCGGTGATGCACTGCGTGCCGCACGCAAACAGCTCGGGCTGACACAGCCTCA
GCTGGCTCTGGCGGCTGGGGTAGGGGTGCGCTTCATTGTCGAGCTTGAAGCAGGCAAACCCACCTTGCGACTGGAAAACG
TGCTACGGGTCATTGATGCCCTGGGTGGTGAGATTCAGTTGAGCGGGTTGCCATCAACCGTAGTCGACGATCAATGTGAA
GGTGGCAACCATGGTGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References