Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 98703..100230 Replicon plasmid pACP3.2
Accession NZ_CP021364
Organism Acidovorax carolinensis strain P3

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag CBP35_RS20670 Protein ID WP_086929087.1
Coordinates 98953..100230 (+) Length 426 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag CBP35_RS20665 Protein ID WP_086929086.1
Coordinates 98703..98963 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CBP35_RS20640 94031..95116 - 1086 WP_086929084.1 IS630 family transposase -
CBP35_RS20645 95195..95812 - 618 Protein_83 IS5 family transposase -
CBP35_RS20650 96123..97193 + 1071 WP_157896847.1 site-specific integrase -
CBP35_RS20660 97609..98124 + 516 Protein_85 hypothetical protein -
CBP35_RS20665 98703..98963 + 261 WP_086929086.1 helix-turn-helix transcriptional regulator Antitoxin
CBP35_RS20670 98953..100230 + 1278 WP_086929087.1 type II toxin-antitoxin system HipA family toxin Toxin
CBP35_RS20675 100416..100868 + 453 WP_086929088.1 hypothetical protein -
CBP35_RS20680 101640..102686 + 1047 Protein_89 IS30 family transposase -
CBP35_RS20685 102705..103268 - 564 WP_143218421.1 hypothetical protein -
CBP35_RS21780 103732..103989 - 258 WP_157896848.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - sodB 1..156922 156922


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 426 a.a.        Molecular weight: 47103.21 Da        Isoelectric Point: 6.7158

>T76546 WP_086929087.1 NZ_CP021364:98953-100230 [Acidovorax carolinensis]
MVHELEVWVFADRVGTLALVDGRLNFCYLPDWLSHKDAITLSASLPLQAEPFDDRKTRPFFAGLLPEGQMRRLIAKQFQV
SGQNDFALLDHIGGECAGAVTFLEPGQALPVPTRSDDVQWLSDEEVVAILDELPRRPMLAGQDGLRLSLAGAQDKLPVVF
DGARIGLPLNGTPSSHILKPAIHAVEDSVSNEGFCMALAEAMQLKPAKSKVHKVLDCSFLLVERYDRLIDAQGNRQRLHQ
EDFCQALGVVPEMKYQNEGGPDLAQCFDLLRSATRPSAPQVLRLLDYVIFNALIGNHDAHAKNFSLLYSGKAPVLAPSYD
MLSTAVYPTLTQNMAMKIGSKYKFSEVQARHWEQFAESVGLTKAQAKRRILELAKLLPANARKLQFAPERGFVKNDVVEQ
ISTLIEHRCALTIRRLNVPATESSV

Download         Length: 1278 bp

>T76546 NZ_CP021364:98953-100230 [Acidovorax carolinensis]
ATGGTGCATGAACTGGAAGTCTGGGTTTTTGCAGATCGTGTCGGCACGTTGGCGCTGGTTGATGGTCGACTCAACTTTTG
CTACCTACCCGATTGGCTGTCACACAAGGACGCCATCACCTTGTCTGCCTCGCTGCCCCTGCAAGCGGAGCCGTTCGACG
ATCGCAAAACGCGCCCCTTCTTTGCGGGTCTTCTGCCCGAAGGGCAGATGCGCCGCTTGATTGCGAAACAATTCCAAGTT
TCAGGCCAGAACGACTTTGCACTGCTGGACCACATTGGCGGCGAATGCGCCGGGGCTGTGACGTTCCTAGAGCCGGGACA
AGCTTTGCCTGTGCCGACCCGTAGCGATGACGTTCAATGGCTGAGCGACGAGGAAGTTGTTGCCATCCTGGATGAACTAC
CGCGCCGCCCCATGTTGGCAGGCCAAGACGGCTTGCGGCTTTCATTGGCAGGTGCCCAGGACAAACTACCGGTGGTGTTT
GACGGTGCCCGCATTGGTCTGCCCCTCAACGGAACGCCTAGCTCGCATATCCTGAAACCGGCCATTCACGCTGTTGAAGA
CAGCGTTAGCAACGAGGGATTCTGCATGGCACTGGCTGAGGCCATGCAGCTCAAGCCAGCGAAATCAAAAGTACACAAGG
TATTGGATTGCTCCTTTCTGCTGGTTGAACGCTACGACCGACTGATTGATGCGCAGGGGAACCGTCAACGCCTTCATCAA
GAGGATTTCTGCCAGGCGCTGGGTGTGGTGCCAGAAATGAAATACCAAAATGAAGGTGGTCCGGATCTGGCGCAGTGCTT
TGATCTGTTACGCAGTGCGACACGCCCCAGTGCACCGCAGGTTCTGCGACTGCTCGACTATGTGATCTTCAATGCGCTGA
TCGGCAATCATGATGCGCACGCCAAGAATTTCTCACTGCTGTACTCGGGCAAGGCGCCCGTTCTGGCACCGTCTTACGAC
ATGCTCTCGACGGCAGTGTATCCAACACTGACGCAAAATATGGCGATGAAAATCGGCAGCAAGTACAAGTTCAGCGAAGT
CCAGGCGCGTCACTGGGAGCAGTTTGCTGAAAGCGTCGGGCTAACCAAAGCGCAGGCCAAACGGCGAATTCTGGAGCTTG
CAAAGTTACTGCCAGCGAATGCACGCAAGCTTCAGTTTGCCCCTGAACGAGGTTTTGTGAAGAATGACGTGGTAGAGCAA
ATCAGTACCTTGATAGAACACCGCTGCGCACTGACGATTCGGCGGCTCAACGTCCCCGCCACCGAATCCTCTGTCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 8987.31 Da        Isoelectric Point: 5.7527

>AT76546 WP_086929086.1 NZ_CP021364:98703-98963 [Acidovorax carolinensis]
MTSIRSPQQLGDALRAARKQLGLTQPQLALAAGVGVRFIVELEAGKPTLRLENVLRVIDALGGEIQLSGLPSTVVDDQCE
GGNHGA

Download         Length: 261 bp

>AT76546 NZ_CP021364:98703-98963 [Acidovorax carolinensis]
ATGACATCCATTCGATCCCCGCAACAACTCGGTGATGCACTGCGTGCCGCACGCAAACAGCTCGGGCTGACACAGCCTCA
GCTGGCTCTGGCGGCTGGGGTAGGGGTGCGCTTCATTGTCGAGCTTGAAGCAGGCAAACCCACCTTGCGACTGGAAAACG
TGCTACGGGTCATTGATGCCCTGGGTGGTGAGATTCAGTTGAGCGGGTTGCCATCAACCGTAGTCGACGATCAATGTGAA
GGTGGCAACCATGGTGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References