Detailed information of TA system TA076541

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-Phd
• Location: 2552068..2552732
• Replicon: chromosome
• Accession: NZ_CP021359
• Organism: Acidovorax carolinensis strain NA2

Toxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: CBP33_RS11955
• Protein ID: WP_086912736.1
• Coordinates: 2552319..2552732 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: CBP33_RS11950
• Protein ID: WP_086914114.1
• Coordinates: 2552068..2552322 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CBP33_RS11945	2547409..2551956	-	4548	WP_086912735.1	N-6 DNA methylase	-
CBP33_RS11950	2552068..2552322	+	255	WP_086914114.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CBP33_RS11955	2552319..2552732	+	414	WP_086912736.1	type II toxin-antitoxin system VapC family toxin	Toxin
CBP33_RS11960	2552804..2555692	-	2889	WP_086912737.1	DEAD/DEAH box helicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-121)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-49)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15353.64 Da
• Isoelectric Point: 7.2048

>T76541 WP_086912736.1 NZ_CP021359:2552319-2552732 [Acidovorax carolinensis]
VSYLVDTNVLSELRRKQPDARVVAWMEQRPAQALYLSVLTLGEIRKGIERLQGDTRQAALLDWLEVELPRFFWGRVLAVD
AHTADRWGRLQGSAGRPLPAIDSLLAATVLQHDLTLVTRNTADFDGLGVRLVNPWLG

Nucleotide

• Length: 414 bp

>T76541 NZ_CP021359:2552319-2552732 [Acidovorax carolinensis]
GTGAGCTATCTGGTGGATACCAATGTGCTGTCGGAGTTGCGGCGCAAGCAGCCCGATGCGCGCGTGGTGGCCTGGATGGA
GCAGCGCCCCGCCCAGGCGCTGTACCTGAGCGTGCTGACGCTGGGGGAGATCCGCAAAGGCATTGAGCGGCTGCAGGGCG
ATACCCGCCAGGCGGCGCTGCTGGACTGGCTGGAGGTGGAGCTGCCCCGGTTTTTTTGGGGCCGCGTGCTGGCGGTGGAC
GCCCACACCGCCGACCGCTGGGGCCGCCTGCAAGGCAGCGCGGGCCGCCCGCTGCCCGCCATCGACAGCCTGCTGGCCGC
CACGGTGCTGCAGCACGACCTGACACTGGTGACGCGCAACACCGCCGACTTTGACGGCCTGGGGGTGCGGCTGGTGAACC
CGTGGCTGGGGTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9346.59 Da
• Isoelectric Point: 5.6175

>AT76541 WP_086914114.1 NZ_CP021359:2552068-2552322 [Acidovorax carolinensis]
VQTWQIQTAKARFSELVKQAAEDGPQEITLHGKPVAVVLSHEAFERLSGGGAPSLVEFMRRSPLHGLDELVLERDRSPTR
EVEL

Nucleotide

• Length: 255 bp

>AT76541 NZ_CP021359:2552068-2552322 [Acidovorax carolinensis]
GTGCAAACATGGCAAATACAGACCGCCAAGGCGCGGTTTTCAGAGCTGGTGAAGCAGGCGGCCGAGGATGGGCCGCAAGA
GATCACGCTGCATGGCAAGCCGGTGGCGGTGGTGCTGTCGCACGAGGCGTTTGAGCGGCTGAGCGGTGGGGGAGCGCCGT
CGCTGGTGGAGTTCATGCGCCGCTCGCCCCTGCATGGGCTGGATGAATTGGTGCTGGAGCGCGACCGCAGCCCTACGCGC
GAGGTGGAGCTGTGA