Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 534997..535562 Replicon chromosome
Accession NZ_CP021359
Organism Acidovorax carolinensis strain NA2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CBP33_RS02590 Protein ID WP_086911251.1
Coordinates 535191..535562 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CBP33_RS02585 Protein ID WP_086911250.1
Coordinates 534997..535194 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CBP33_RS02560 530442..531218 - 777 WP_086911245.1 hypothetical protein -
CBP33_RS02565 531257..531919 - 663 WP_086911246.1 TetR/AcrR family transcriptional regulator -
CBP33_RS02570 532141..532725 - 585 WP_086911247.1 phasin family protein -
CBP33_RS02575 532962..534047 + 1086 WP_086911248.1 dTDP-glucose 4,6-dehydratase -
CBP33_RS02580 534044..534937 + 894 WP_086911249.1 dTDP-4-dehydrorhamnose reductase -
CBP33_RS02585 534997..535194 + 198 WP_086911250.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CBP33_RS02590 535191..535562 + 372 WP_086911251.1 type II toxin-antitoxin system VapC family toxin Toxin
CBP33_RS02595 535583..536491 + 909 WP_086911252.1 glucose-1-phosphate thymidylyltransferase RfbA -
CBP33_RS02600 536499..537044 + 546 WP_086911253.1 dTDP-4-dehydrorhamnose 3,5-epimerase -
CBP33_RS02605 537059..538195 + 1137 WP_086911254.1 glycosyltransferase -
CBP33_RS02610 538168..539310 - 1143 WP_086911255.1 glycosyltransferase family 4 protein -
CBP33_RS02615 539326..540192 - 867 WP_086911256.1 GDP-mannose 4,6-dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-111)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-46)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13535.76 Da        Isoelectric Point: 6.2106

>T76538 WP_086911251.1 NZ_CP021359:535191-535562 [Acidovorax carolinensis]
VMLVDTSVWVDHLRQGEPELTAALQAGQVDMHPFVVGELACGNLRARAEVLGLLQALPQIQVATDKEMLFFMDAHALMGR
GIGYVDMHLLAATRLGAQLLWTRDKRLHAIAVELGLAHTETRN

Download         Length: 372 bp

>T76538 NZ_CP021359:535191-535562 [Acidovorax carolinensis]
GTGATGCTGGTGGACACATCCGTCTGGGTTGACCATTTGCGCCAGGGTGAGCCCGAGCTGACAGCAGCACTTCAAGCAGG
GCAGGTCGATATGCATCCTTTTGTGGTGGGAGAGCTGGCCTGCGGAAACTTGCGGGCACGCGCCGAGGTACTGGGCCTGC
TGCAGGCGCTACCCCAGATCCAGGTGGCCACCGACAAGGAAATGCTGTTTTTTATGGATGCGCACGCACTCATGGGGCGT
GGCATAGGCTATGTGGATATGCATCTGCTGGCAGCCACACGGCTGGGTGCACAACTACTCTGGACGCGCGACAAGAGGCT
GCACGCCATCGCCGTCGAACTGGGTTTGGCGCATACCGAAACACGGAACTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7349.44 Da        Isoelectric Point: 9.4987

>AT76538 WP_086911250.1 NZ_CP021359:534997-535194 [Acidovorax carolinensis]
MRTTLTLDDELLAQAQQISGLTERTLLIREALLALVQRESARRLARLGGTEPQLQPTPRRREPEA

Download         Length: 198 bp

>AT76538 NZ_CP021359:534997-535194 [Acidovorax carolinensis]
ATGCGCACCACACTCACTCTTGACGATGAATTGCTCGCACAGGCGCAGCAAATCAGTGGTTTAACTGAACGTACCCTGTT
GATCCGCGAAGCACTGCTGGCGCTGGTGCAACGCGAGAGCGCGCGCCGGCTGGCCCGGCTCGGCGGGACTGAACCCCAAT
TGCAGCCCACACCCCGCCGCAGAGAACCTGAAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References