Detailed information of TA system TA076537

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-YefM
• Location: 2247908..2248410
• Replicon: chromosome
• Accession: NZ_CP021358
• Organism: Kushneria marisflavi strain SW32

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: B9H00_RS10250
• Protein ID: WP_086900577.1
• Coordinates: 2248156..2248410 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: B9H00_RS10245
• Protein ID: WP_086900576.1
• Coordinates: 2247908..2248159 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B9H00_RS10230	2243923..2244996	-	1074	WP_086900573.1	biotin synthase BioB	-
B9H00_RS10235	2245222..2247339	+	2118	WP_147376573.1	ferric-rhodotorulic acid/ferric-coprogen receptor FhuE	-
B9H00_RS10240	2247449..2247835	+	387	WP_086900575.1	DUF2007 domain-containing protein	-
B9H00_RS10245	2247908..2248159	+	252	WP_086900576.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
B9H00_RS10250	2248156..2248410	+	255	WP_086900577.1	Txe/YoeB family addiction module toxin	Toxin
B9H00_RS10255	2249155..2251422	+	2268	Protein_1993	AAA family ATPase	-
B9H00_RS10260	2251794..2252576	+	783	WP_086900578.1	carbon-nitrogen hydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10184.64 Da
• Isoelectric Point: 9.4089

>T76537 WP_086900577.1 NZ_CP021358:2248156-2248410 [Kushneria marisflavi]
VKRLFSEKAWEDDLYWQTTDKKVLGRINKLIREIQCQPFEGVGKPEQLGHGFSRYWSRRINDEHRIVYKVTDDALMIAQL
RYHY

Nucleotide

• Length: 255 bp

>T76537 NZ_CP021358:2248156-2248410 [Kushneria marisflavi]
GTGAAGCGCCTGTTTTCCGAGAAGGCCTGGGAGGATGACCTGTACTGGCAGACAACCGACAAGAAGGTGCTCGGGCGCAT
CAACAAACTGATCAGGGAAATCCAGTGCCAGCCATTTGAAGGTGTAGGTAAACCGGAGCAGCTTGGGCACGGCTTTTCAA
GGTATTGGTCCCGGCGAATCAACGACGAGCATCGAATTGTTTATAAAGTGACAGACGACGCGCTGATGATTGCGCAGCTT
CGATATCACTATTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9298.56 Da
• Isoelectric Point: 4.4621

>AT76537 WP_086900576.1 NZ_CP021358:2247908-2248159 [Kushneria marisflavi]
MDAISYTAARSQLSKTMEQVCEDHAPIVITRSRAPSVVMLSLEDYEALQETAYLLRSPKNARRLLESMAELEQGDGQEKA
LLE

Nucleotide

• Length: 252 bp

>AT76537 NZ_CP021358:2247908-2248159 [Kushneria marisflavi]
ATGGATGCCATCAGCTACACCGCTGCCAGAAGCCAGCTGTCCAAAACCATGGAACAGGTGTGTGAAGACCACGCGCCCAT
CGTCATCACGCGCAGCAGGGCGCCTTCGGTGGTCATGCTCTCGCTGGAAGACTACGAGGCGCTGCAGGAAACCGCCTATC
TTCTGCGCTCACCCAAAAACGCCCGACGCCTGCTGGAATCCATGGCCGAGCTGGAGCAGGGCGACGGTCAGGAAAAGGCG
CTTCTTGAGTGA