Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 1995169..1995822 Replicon chromosome
Accession NZ_CP021347
Organism Acinetobacter baumannii strain B8300

Toxin (Protein)


Gene name cptA Uniprot ID A0A829RKD8
Locus tag AB987_RS09760 Protein ID WP_002125600.1
Coordinates 1995433..1995822 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag AB987_RS09755 Protein ID WP_001288210.1
Coordinates 1995169..1995426 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB987_RS09735 1990685..1991692 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
AB987_RS09740 1991711..1992088 + 378 WP_001216380.1 50S ribosomal protein L17 -
AB987_RS09745 1992270..1993760 + 1491 WP_049590832.1 NAD(P)/FAD-dependent oxidoreductase -
AB987_RS09750 1993809..1994981 - 1173 WP_002125555.1 acyl-CoA dehydrogenase family protein -
AB987_RS09755 1995169..1995426 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
AB987_RS09760 1995433..1995822 + 390 WP_002125600.1 hypothetical protein Toxin
AB987_RS09765 1996592..1997677 + 1086 WP_049590833.1 hypothetical protein -
AB987_RS09770 1997755..1998321 + 567 WP_000651536.1 rhombosortase -
AB987_RS09775 1998509..2000704 + 2196 WP_001158905.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15662.98 Da        Isoelectric Point: 10.4623

>T76530 WP_002125600.1 NZ_CP021347:1995433-1995822 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKIWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKKLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T76530 NZ_CP021347:1995433-1995822 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAAATATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCACGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAAAACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT76530 WP_001288210.1 NZ_CP021347:1995169-1995426 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT76530 NZ_CP021347:1995169-1995426 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCATTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829RKD8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References