Detailed information of TA system TA076529

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2800138..2800789
• Replicon: chromosome
• Accession: NZ_CP021342
• Organism: Acinetobacter baumannii strain B8342

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: AB895_RS13575
• Protein ID: WP_049594630.1
• Coordinates: 2800138..2800320 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: L9LVK3
• Locus tag: AB895_RS13580
• Protein ID: WP_002053018.1
• Coordinates: 2800385..2800789 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AB895_RS13525	2795264..2795653	+	390	WP_000008494.1	hypothetical protein	-
AB895_RS13530	2795655..2796023	+	369	WP_049594625.1	hypothetical protein	-
AB895_RS13535	2796061..2796771	+	711	WP_053094133.1	hypothetical protein	-
AB895_RS13540	2796821..2797234	+	414	WP_049594626.1	hypothetical protein	-
AB895_RS13545	2797200..2797568	+	369	WP_030423714.1	hypothetical protein	-
AB895_RS13550	2797570..2797968	+	399	WP_030423713.1	hypothetical protein	-
AB895_RS13555	2797970..2798182	+	213	WP_030423712.1	hypothetical protein	-
AB895_RS13560	2798288..2799223	+	936	WP_049594627.1	hypothetical protein	-
AB895_RS13565	2799273..2799806	+	534	WP_049594628.1	hypothetical protein	-
AB895_RS13570	2799809..2800069	+	261	WP_053095362.1	hypothetical protein	-
AB895_RS13575	2800138..2800320	+	183	WP_049594630.1	type II toxin-antitoxin system HicA family toxin	Toxin
AB895_RS13580	2800385..2800789	+	405	WP_002053018.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
AB895_RS13585	2800885..2801403	+	519	WP_005070358.1	DUF4468 domain-containing protein	-
AB895_RS13590	2801500..2805291	+	3792	Protein_2601	tape measure protein	-
AB895_RS13595	2805498..2805761	+	264	WP_049594631.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2769948..2834072	64124

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6709.91 Da
• Isoelectric Point: 10.6602

>T76529 WP_049594630.1 NZ_CP021342:2800138-2800320 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLK

Nucleotide

• Length: 183 bp

>T76529 NZ_CP021342:2800138-2800320 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTAACAATCCCTCATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAAGTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14660.69 Da
• Isoelectric Point: 4.4289

>AT76529 WP_002053018.1 NZ_CP021342:2800385-2800789 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASDLAKFVDDPDYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT76529 NZ_CP021342:2800385-2800789 [Acinetobacter baumannii]
ATGTTGTATCCAATTGCTATCGAGAGAGGTACAGACACCGAAGCCTTTGGTGTCACCGTTCCAGATATTCCAGGATGTTT
TAGCGCAGGCGATACATTAGAGGAAGCTATCGAGAACGTTAAAGAGGCAATTTCTGGTCACTTAGAAATCCTTGCTGAAG
ATGGAGAAGAAATTCCATTAGCATCTGACTTAGCAAAATTTGTAGATGATCCAGATTATAAAGGCATGATCTGGGCTGTT
ACTGAGGTGGATGTTAGTCGTTATCTTGGTAAGCCTGAAAAAATCAACGTAACTTTACCTAGCCGTTTAATTCGCAAGAT
TGATGATAATGTAGGTAAAGATAAAAGATTTAAAACTCGTTCTGCTTTTTTGGCCGCTGGTGCTGAAAAGCTACTACATG
CTTAA

Structures

Antitoxin

• AlphaFold DB: A0A5Q0RVR6