Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-RelB
Location 1664940..1665453 Replicon chromosome
Accession NZ_CP021342
Organism Acinetobacter baumannii strain B8342

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2L2M0A2
Locus tag AB895_RS07950 Protein ID WP_000203952.1
Coordinates 1664940..1665203 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S7WSW9
Locus tag AB895_RS07955 Protein ID WP_000557943.1
Coordinates 1665190..1665453 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB895_RS07920 1661030..1662460 + 1431 WP_000178999.1 amino acid permease -
AB895_RS07925 1662518..1662862 - 345 Protein_1516 LysR family transcriptional regulator -
AB895_RS07930 1662901..1664134 - 1234 Protein_1517 IS3 family transposase -
AB895_RS07940 1664193..1664510 - 318 Protein_1518 LysR family transcriptional regulator -
AB895_RS19245 1664644..1664742 + 99 Protein_1519 IS5/IS1182 family transposase -
AB895_RS07945 1664774..1664881 - 108 Protein_1520 transposase domain-containing protein -
AB895_RS07950 1664940..1665203 - 264 WP_000203952.1 Txe/YoeB family addiction module toxin Toxin
AB895_RS07955 1665190..1665453 - 264 WP_000557943.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
AB895_RS07960 1665869..1669216 + 3348 WP_049594593.1 DEAD/DEAH box helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1662901..1675713 12812


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10664.10 Da        Isoelectric Point: 8.4894

>T76527 WP_000203952.1 NZ_CP021342:c1665203-1664940 [Acinetobacter baumannii]
MTSRNVEWTENAWDEYIYWQTQDKKILKRINTLIRECQRTPFEGTGKPEPLKANLSGFWSRRIDEKHRLVYEVTDERISI
IQCRFHY

Download         Length: 264 bp

>T76527 NZ_CP021342:c1665203-1664940 [Acinetobacter baumannii]
ATGACGAGTCGTAATGTCGAATGGACTGAAAATGCCTGGGATGAATATATCTATTGGCAAACACAGGATAAAAAGATACT
CAAACGTATCAATACCTTAATCAGAGAATGTCAAAGAACACCCTTTGAAGGAACTGGGAAACCAGAACCTTTAAAAGCAA
ATCTTTCAGGATTCTGGAGCCGTAGAATTGATGAGAAGCATAGATTAGTTTATGAAGTGACGGATGAACGAATTTCCATT
ATTCAATGTCGGTTCCATTACTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9841.04 Da        Isoelectric Point: 5.5940

>AT76527 WP_000557943.1 NZ_CP021342:c1665453-1665190 [Acinetobacter baumannii]
MHVFTYTDARNNLKSVLDKVIDDADVAFITRKEGGHAVVMGQDHYDSLMETLYLLSSPNNTTRLNESIAQLRAGKTKQRE
LIKDDES

Download         Length: 264 bp

>AT76527 NZ_CP021342:c1665453-1665190 [Acinetobacter baumannii]
ATGCATGTATTTACATATACAGACGCACGTAACAACTTAAAATCTGTTTTAGATAAAGTTATTGATGATGCAGATGTCGC
TTTCATTACAAGAAAAGAAGGCGGTCATGCTGTAGTAATGGGACAAGATCATTACGATAGTTTAATGGAAACGTTGTATC
TCCTTTCATCTCCAAATAATACCACTCGTTTAAACGAATCAATTGCTCAATTACGCGCAGGTAAAACCAAACAAAGAGAG
TTGATTAAAGATGACGAGTCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L2M0A2

Antitoxin

Source ID Structure
AlphaFold DB S7WSW9

References