Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 1078166..1078819 Replicon chromosome
Accession NZ_CP021342
Organism Acinetobacter baumannii strain B8342

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J8TGE7
Locus tag AB895_RS05075 Protein ID WP_024437032.1
Coordinates 1078166..1078555 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag AB895_RS05080 Protein ID WP_001288210.1
Coordinates 1078562..1078819 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB895_RS05060 1073284..1075479 - 2196 WP_001158905.1 TRAP transporter large permease subunit -
AB895_RS05065 1075667..1076233 - 567 WP_000651536.1 rhombosortase -
AB895_RS05070 1076311..1077396 - 1086 WP_000049106.1 hypothetical protein -
AB895_RS05075 1078166..1078555 - 390 WP_024437032.1 membrane protein Toxin
AB895_RS05080 1078562..1078819 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
AB895_RS05085 1079007..1080179 + 1173 WP_049594544.1 acyl-CoA dehydrogenase family protein -
AB895_RS05090 1080227..1081381 - 1155 WP_004738527.1 IS4 family transposase -
AB895_RS05095 1081509..1082999 - 1491 WP_000415132.1 NAD(P)/FAD-dependent oxidoreductase -
AB895_RS05100 1083181..1083558 - 378 WP_001216380.1 50S ribosomal protein L17 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1080227..1081381 1154


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15584.82 Da        Isoelectric Point: 10.3889

>T76526 WP_024437032.1 NZ_CP021342:c1078555-1078166 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAALFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYQSQNTV
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T76526 NZ_CP021342:c1078555-1078166 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGCTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT76526 WP_001288210.1 NZ_CP021342:c1078819-1078562 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT76526 NZ_CP021342:c1078819-1078562 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J8TGE7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References