Detailed information of TA system TA076460

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 4180590..4181341
• Replicon: chromosome
• Accession: NZ_CP021329
• Organism: Raoultella ornithinolytica strain Ro24724

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: -
• Locus tag: CA210_RS22750
• Protein ID: WP_044351088.1
• Coordinates: 4180859..4181341 (+)
• Length: 161 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: A0A808Y4Y8
• Locus tag: CA210_RS22745
• Protein ID: WP_015584326.1
• Coordinates: 4180590..4180868 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CA210_RS22735	4177379..4177876	+	498	WP_048023692.1	hypothetical protein	-
CA210_RS22740	4178034..4179959	-	1926	WP_088884162.1	C1 family peptidase	-
CA210_RS22745	4180590..4180868	+	279	WP_015584326.1	DUF1778 domain-containing protein	Antitoxin
CA210_RS22750	4180859..4181341	+	483	WP_044351088.1	GNAT family N-acetyltransferase	Toxin
CA210_RS29165	4181526..4181876	+	351	WP_044351090.1	hypothetical protein	-
CA210_RS22760	4182047..4182754	-	708	WP_088883965.1	toll/interleukin-1 receptor domain-containing protein	-
CA210_RS22765	4182911..4184257	-	1347	WP_088884163.1	ISNCY family transposase	-
CA210_RS29170	4184462..4184620	-	159	WP_157721034.1	hypothetical protein	-
CA210_RS22775	4185346..4186221	-	876	WP_088883966.1	NAD(P)-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	4172114..4338946	166832
	-	flank	IS/Tn	-	-	4182911..4184269	1358

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (45-144)

Antitoxin

• Vibrio phage ICP1, Orf50 (3-92)

Sequences

Toxin

Protein

• Length: 161 a.a.
• Molecular weight: 17612.48 Da
• Isoelectric Point: 9.7381

>T76460 WP_044351088.1 NZ_CP021329:4180859-4181341 [Raoultella ornithinolytica]
MGMRPPEPLSAGHNIAEFCCQDQVLNEWLKKKALKNHSTGISRVFVVCAENTKRVIAYYSLSSGSVHRNTVPGAYRRNAP
EAVPVIVLGRLAVDAAWAGKGLGAALLKDAIYRTEHIAVQVGVRALLVHALNDEVREFYTRFGFEPSIINTLTLLFPIKV

Nucleotide

• Length: 483 bp

>T76460 NZ_CP021329:4180859-4181341 [Raoultella ornithinolytica]
ATGGGAATGAGACCACCGGAACCACTCAGCGCTGGACACAACATAGCAGAATTTTGTTGTCAGGATCAGGTTCTTAACGA
GTGGTTGAAGAAGAAGGCGCTGAAGAACCACAGTACAGGCATTTCAAGGGTCTTTGTGGTCTGTGCCGAAAACACAAAAA
GGGTCATCGCGTATTACAGCTTGTCATCCGGGAGCGTGCACAGAAACACAGTACCGGGGGCATACCGTCGTAATGCACCT
GAAGCTGTACCGGTCATTGTTCTGGGAAGGCTTGCGGTCGATGCAGCCTGGGCAGGGAAGGGACTCGGAGCGGCACTGCT
TAAGGATGCAATATACCGTACAGAACATATCGCAGTTCAGGTCGGTGTAAGGGCGCTTCTCGTCCATGCCTTGAATGATG
AAGTCAGGGAGTTTTACACCAGGTTTGGATTCGAGCCCTCGATTATCAATACACTGACATTATTGTTCCCGATAAAAGTA
TGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10714.30 Da
• Isoelectric Point: 4.6722

>AT76460 WP_015584326.1 NZ_CP021329:4180590-4180868 [Raoultella ornithinolytica]
MKPDVREAPINIRAKTSQRDLIDMAANLVSKSRTDFMLEVACREAQDILLDQRLFLLDDKQFASFMEELDAPMTAERQAR
IDNLMNRKSPWE

Nucleotide

• Length: 279 bp

>AT76460 NZ_CP021329:4180590-4180868 [Raoultella ornithinolytica]
ATGAAACCAGACGTTCGTGAAGCTCCGATAAACATTCGGGCGAAAACATCTCAGCGCGACCTTATCGACATGGCCGCAAA
TCTTGTATCTAAATCACGTACTGATTTTATGCTTGAAGTGGCCTGTCGCGAAGCTCAGGACATTCTGTTGGATCAGCGCT
TGTTCCTGCTGGACGATAAGCAGTTTGCTAGTTTCATGGAAGAGCTTGACGCACCTATGACAGCGGAGCGTCAGGCACGT
ATTGATAACCTGATGAACCGCAAATCGCCATGGGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A808Y4Y8