Detailed information of TA system TA076459

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 3872787..3873700
• Replicon: chromosome
• Accession: NZ_CP021329
• Organism: Raoultella ornithinolytica strain Ro24724

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: CA210_RS21200
• Protein ID: WP_088883911.1
• Coordinates: 3872787..3873260 (-)
• Length: 158 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A808Y7A4
• Locus tag: CA210_RS21205
• Protein ID: WP_004862777.1
• Coordinates: 3873257..3873700 (-)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CA210_RS21175	3868829..3869437	-	609	WP_032724246.1	glutathione S-transferase family protein	-
CA210_RS21180	3869679..3870584	+	906	WP_032716408.1	transcriptional regulator GcvA	-
CA210_RS21185	3870612..3871517	-	906	WP_044349852.1	LysR family transcriptional regulator	-
CA210_RS21190	3871620..3871937	+	318	WP_004862785.1	nuclear transport factor 2 family protein	-
CA210_RS21195	3871930..3872709	+	780	WP_004862782.1	SDR family oxidoreductase	-
CA210_RS21200	3872787..3873260	-	474	WP_088883911.1	RES domain-containing protein	Toxin
CA210_RS21205	3873257..3873700	-	444	WP_004862777.1	DUF2384 domain-containing protein	Antitoxin
CA210_RS21210	3873890..3874456	-	567	WP_015584190.1	DJ-1/PfpI family protein	-
CA210_RS21215	3874854..3875636	+	783	WP_088883912.1	DUF3750 domain-containing protein	-
CA210_RS21220	3875832..3877055	+	1224	WP_088883913.1	zinc metallochaperone GTPase ZigA	-
CA210_RS21240	3877985..3878461	-	477	WP_088883914.1	acid resistance repetitive basic protein Asr	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 158 a.a.
• Molecular weight: 17510.80 Da
• Isoelectric Point: 4.8081

>T76459 WP_088883911.1 NZ_CP021329:c3873260-3872787 [Raoultella ornithinolytica]
MIFYRLVTGRYASEAWTGSGANQYGGRWNHQGHPAVYVSTSIALASLEILVHVKNEAILNQYQLYSIEIPDSEVESVDKQ
WLPDNWQENPMPVSTMDLGTGWLQSGSGLALMLPSCIIPYENNAILNPLHPAFSEALASVRQYPFTFDPRLARSTPL

Nucleotide

• Length: 474 bp

>T76459 NZ_CP021329:c3873260-3872787 [Raoultella ornithinolytica]
ATGATTTTCTATCGTCTGGTTACCGGCCGTTACGCCAGCGAAGCCTGGACGGGAAGCGGGGCCAACCAGTACGGCGGGCG
CTGGAATCACCAGGGACACCCGGCGGTCTATGTGTCCACTTCCATTGCCCTGGCGTCACTGGAGATCCTGGTTCACGTCA
AAAATGAGGCAATCCTCAACCAGTATCAGCTGTATAGTATCGAGATACCGGACAGCGAAGTGGAATCCGTCGATAAACAG
TGGTTACCGGATAACTGGCAAGAAAATCCGATGCCCGTTTCCACAATGGATCTGGGCACCGGCTGGCTACAGTCGGGCAG
CGGTCTGGCGCTGATGCTTCCCTCCTGCATTATTCCCTATGAAAACAACGCCATTTTAAACCCGCTGCATCCCGCGTTCA
GCGAGGCCCTGGCCTCCGTGCGTCAGTATCCCTTTACCTTTGATCCCCGCCTCGCACGCTCCACGCCCCTCTGA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16190.45 Da
• Isoelectric Point: 4.9405

>AT76459 WP_004862777.1 NZ_CP021329:c3873700-3873257 [Raoultella ornithinolytica]
MKTWVPAEQPADNALWRYAGLPANRGMQLIELLSMGLPVSILDNIHEWTEMSKTDILRITGINERNVARRKSAGGTLTPG
ESERVARFVRVLDTAVDYFGSKQDAYDWLQSPVRGLGNVAPIDLIATESGALEVTDLIGRLEHGVFA

Nucleotide

• Length: 444 bp

>AT76459 NZ_CP021329:c3873700-3873257 [Raoultella ornithinolytica]
ATGAAAACCTGGGTTCCTGCAGAGCAACCTGCCGATAATGCGCTATGGCGCTATGCCGGGCTACCGGCGAATCGGGGTAT
GCAGTTGATTGAGCTGCTGAGTATGGGATTACCGGTCAGCATTCTGGATAATATTCATGAGTGGACGGAAATGTCGAAAA
CCGACATTCTGCGCATCACCGGGATTAATGAGCGCAACGTTGCCCGGCGCAAGAGCGCGGGCGGCACGTTGACGCCAGGC
GAAAGCGAACGTGTGGCGCGTTTTGTCAGGGTCCTGGATACCGCCGTCGACTATTTTGGCAGCAAGCAGGATGCCTACGA
CTGGCTGCAGTCGCCGGTCAGAGGACTGGGCAATGTCGCCCCCATCGATCTGATTGCTACCGAGAGCGGCGCGCTGGAAG
TAACAGACCTGATTGGTCGCCTGGAACACGGCGTCTTTGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A808Y7A4