Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2262939..2263596 Replicon chromosome
Accession NZ_CP021329
Organism Raoultella ornithinolytica strain Ro24724

Toxin (Protein)


Gene name cptA Uniprot ID A0A808XTM6
Locus tag CA210_RS13740 Protein ID WP_004867355.1
Coordinates 2263186..2263596 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A514ELX1
Locus tag CA210_RS13735 Protein ID WP_004867358.1
Coordinates 2262939..2263205 (+) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA210_RS13710 2258075..2259508 - 1434 WP_004867372.1 6-phospho-beta-glucosidase -
CA210_RS13715 2259628..2260356 - 729 WP_004867368.1 MurR/RpiR family transcriptional regulator -
CA210_RS13720 2260406..2260717 + 312 WP_004867365.1 N(4)-acetylcytidine aminohydrolase -
CA210_RS13725 2260879..2261537 + 659 Protein_2076 hemolysin III family protein -
CA210_RS13730 2261659..2262642 - 984 WP_004867359.1 tRNA-modifying protein YgfZ -
CA210_RS13735 2262939..2263205 + 267 WP_004867358.1 FAD assembly factor SdhE Antitoxin
CA210_RS13740 2263186..2263596 + 411 WP_004867355.1 protein YgfX Toxin
CA210_RS13745 2263604..2264125 - 522 WP_004867353.1 flavodoxin FldB -
CA210_RS13750 2264304..2265200 + 897 WP_088883675.1 site-specific tyrosine recombinase XerD -
CA210_RS13755 2265223..2265936 + 714 WP_004867349.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CA210_RS13760 2265942..2267675 + 1734 WP_064356671.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-132)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 137 a.a.        Molecular weight: 16226.16 Da        Isoelectric Point: 11.3349

>T76450 WP_004867355.1 NZ_CP021329:2263186-2263596 [Raoultella ornithinolytica]
VVLWQSDLRISWRSQWFSLLLHGIVAAIVLLMPWPLSYTPLWLLLLSLVVFDSVRSQRRIHACRGEIKLMTDSRLRWQKA
EWEIVGTPWVINSGMLLRLQDMQTRRRQHLWIAADSMDAKEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T76450 NZ_CP021329:2263186-2263596 [Raoultella ornithinolytica]
GTGGTCCTGTGGCAATCTGATTTACGCATCTCCTGGCGCTCACAGTGGTTCTCGCTGCTGCTGCACGGCATTGTGGCGGC
TATTGTGCTGCTGATGCCCTGGCCGCTGAGCTACACGCCGCTATGGCTATTGCTGCTGTCGCTGGTGGTGTTCGACAGCG
TGCGCAGCCAGCGGCGGATCCACGCCTGTCGGGGGGAAATAAAGCTGATGACCGATTCGCGTTTGCGTTGGCAAAAAGCG
GAATGGGAGATTGTCGGCACGCCGTGGGTGATTAATAGCGGGATGTTGCTGCGTCTGCAGGATATGCAAACGCGTCGCCG
CCAGCATCTGTGGATCGCTGCAGACAGTATGGACGCCAAAGAGTGGCGAGATCTGCGCCGGTTGGTGTTACAAAAACCGG
CACAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10553.05 Da        Isoelectric Point: 4.8432

>AT76450 WP_004867358.1 NZ_CP021329:2262939-2263205 [Raoultella ornithinolytica]
MDITNKARIHWACRRGMRELDISIMPFFEYEYDTLSDEDKQLFIRLLENDDPDLFNWLMNHGEPADAQLQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT76450 NZ_CP021329:2262939-2263205 [Raoultella ornithinolytica]
ATGGACATTACGAATAAAGCCCGCATCCACTGGGCATGCCGCAGGGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTCGAGTATGAGTACGATACGCTCAGCGATGAAGACAAACAGCTGTTTATCCGTCTGTTAGAAAACGACGATCCGGATC
TGTTTAACTGGCTGATGAATCATGGCGAACCGGCTGATGCGCAACTGCAACGGATGGTAAAATTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A808XTM6


Antitoxin

Source ID Structure
AlphaFold DB A0A514ELX1

References