Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1432664..1433211 Replicon chromosome
Accession NZ_CP021329
Organism Raoultella ornithinolytica strain Ro24724

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag CA210_RS09540 Protein ID WP_088883551.1
Coordinates 1432664..1432972 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag CA210_RS09545 Protein ID WP_088883552.1
Coordinates 1432975..1433211 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA210_RS09510 1427843..1428145 - 303 WP_015585486.1 PTS lactose/cellobiose transporter subunit IIA -
CA210_RS09515 1428280..1429605 - 1326 WP_004869064.1 PTS cellobiose transporter subunit IIC -
CA210_RS09520 1429617..1429931 - 315 WP_004869063.1 PTS sugar transporter subunit IIB -
CA210_RS09525 1430226..1431167 + 942 WP_015585487.1 LacI family transcriptional regulator -
CA210_RS09530 1431262..1431537 - 276 WP_160873538.1 hypothetical protein -
CA210_RS09535 1431646..1432548 - 903 WP_015585496.1 EamA family transporter -
CA210_RS09540 1432664..1432972 - 309 WP_088883551.1 CcdB family protein Toxin
CA210_RS09545 1432975..1433211 - 237 WP_088883552.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
CA210_RS09550 1433317..1434750 - 1434 WP_069476354.1 PTS N-acetylmuramic acid transporter subunit IIBC -
CA210_RS09555 1434775..1435677 - 903 WP_088883553.1 N-acetylmuramic acid 6-phosphate etherase -
CA210_RS09560 1435842..1437005 - 1164 WP_004869055.1 multidrug effflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11794.61 Da        Isoelectric Point: 6.7154

>T76449 WP_088883551.1 NZ_CP021329:c1432972-1432664 [Raoultella ornithinolytica]
IQYYVYKNTGRITVYPYLLDVQSDIIGMRNTRVVIPLFPLRNYKGPRADRLTPVVTVEGEEYVVMTHELASIPQRVLGEE
VCHLNHQREVVKASIDFLYDGI

Download         Length: 309 bp

>T76449 NZ_CP021329:c1432972-1432664 [Raoultella ornithinolytica]
ATACAGTATTACGTTTATAAAAATACCGGTCGAATTACTGTGTATCCTTATCTCCTTGATGTACAAAGTGACATTATTGG
AATGCGCAATACCCGGGTCGTGATCCCACTATTCCCGCTGAGAAATTACAAAGGTCCGCGCGCCGATCGTTTAACACCAG
TTGTCACCGTAGAAGGGGAAGAATACGTCGTGATGACTCACGAACTCGCCAGCATCCCACAACGCGTTCTGGGGGAAGAG
GTTTGTCATCTCAATCACCAACGTGAAGTCGTTAAAGCATCAATAGATTTTCTTTATGACGGGATTTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8913.05 Da        Isoelectric Point: 5.6579

>AT76449 WP_088883552.1 NZ_CP021329:c1433211-1432975 [Raoultella ornithinolytica]
MPAVKHNKQNVSVTQDPILVKQAREIGINLSQTLTSALKSEIHSIEMARWQKENARAIDYLNDLTEENGLLSDEYRTF

Download         Length: 237 bp

>AT76449 NZ_CP021329:c1433211-1432975 [Raoultella ornithinolytica]
ATGCCAGCCGTAAAACACAATAAGCAGAATGTCAGCGTGACGCAGGATCCTATACTGGTCAAACAGGCTCGTGAGATCGG
CATCAATCTTTCTCAAACGTTGACGAGCGCTCTAAAAAGCGAAATCCACAGCATCGAAATGGCACGCTGGCAAAAAGAAA
ATGCCAGGGCAATCGACTACCTCAATGATTTAACAGAGGAAAATGGACTTCTCTCTGACGAATACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References