Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 2571554..2573010 Replicon chromosome
Accession NZ_CP021283
Organism Legionella pneumophila subsp. pneumophila strain Allentown

Toxin (Protein)


Gene name rlegT Uniprot ID -
Locus tag CA921_RS11495 Protein ID WP_061401155.1
Coordinates 2571554..2572405 (-) Length 284 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID -
Locus tag CA921_RS11500 Protein ID WP_061401188.1
Coordinates 2572402..2573010 (-) Length 203 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA921_RS11470 2567066..2567506 + 441 WP_042754801.1 conjugal transfer protein TraM -
CA921_RS11475 2567671..2568288 + 618 WP_061401158.1 putative DNA binding domain-containing protein -
CA921_RS11480 2568430..2569128 + 699 WP_061401157.1 hypothetical protein -
CA921_RS11485 2569516..2570934 + 1419 WP_011214461.1 IS4-like element ISLpn2 family transposase -
CA921_RS16635 2570966..2571046 - 81 WP_072356411.1 transposase -
CA921_RS11490 2571055..2571474 + 420 Protein_2216 DUF2779 domain-containing protein -
CA921_RS11495 2571554..2572405 - 852 WP_061401155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
CA921_RS11500 2572402..2573010 - 609 WP_061401188.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
CA921_RS11510 2573518..2573919 + 402 WP_061401153.1 hypothetical protein -
CA921_RS11525 2574683..2575831 + 1149 WP_061401150.1 outer membrane beta-barrel protein -
CA921_RS11530 2575861..2576979 + 1119 WP_061401149.1 DUF3494 domain-containing protein -
CA921_RS16670 2577283..2577441 + 159 WP_154694733.1 hypothetical protein -
CA921_RS11535 2577489..2577830 + 342 WP_061401148.1 IS630 transposase-related protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2569516..2570934 1418


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(35-262)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(9-56)


Sequences

Toxin        


Download         Length: 284 a.a.        Molecular weight: 31761.72 Da        Isoelectric Point: 6.7342

>T76392 WP_061401155.1 NZ_CP021283:c2572405-2571554 [Legionella pneumophila subsp. pneumophila]
MIKNIGESVRSRLKNIAVKEGSDFNAVLTRYGLERLLYRIGESEYSNQFLLKGALLFNLWYDMPHRPTKDIDLLGFGDND
LAYIKQTFSKICSIFADDGISFLSESVTVDTIKKDGGYTGARVELFGELAKAKIKIQIDIGYSDAVTPGPIDAHYPVLLS
DLPAPKIRTYPIYTVIAEKLHAIALLGMANSRLKNYLDLYVLLGNEQIDNQILAKAIQATFNRRGMDLPEALPIGLTDEF
ANDPSRESMWKAFLRKNELEQKPLTEVIAVIRNLIQVPYSLAK

Download         Length: 852 bp

>T76392 NZ_CP021283:c2572405-2571554 [Legionella pneumophila subsp. pneumophila]
ATGATCAAAAATATTGGTGAGTCCGTACGCTCACGTTTGAAGAATATAGCTGTTAAAGAAGGTTCTGATTTTAATGCGGT
ATTGACTCGTTATGGTCTAGAGCGTTTGTTGTATCGAATTGGAGAATCAGAATATTCTAACCAGTTTTTGTTGAAAGGTG
CCTTACTGTTTAACCTATGGTACGACATGCCCCATCGCCCAACTAAAGATATTGATTTATTGGGATTTGGTGATAACGAT
CTGGCGTATATTAAGCAAACGTTCAGTAAAATTTGCAGTATCTTTGCAGATGATGGAATAAGTTTTCTGTCTGAATCAGT
GACGGTTGACACTATCAAAAAAGATGGAGGTTATACTGGAGCAAGAGTTGAGTTATTTGGGGAATTGGCGAAAGCAAAGA
TTAAAATACAAATTGATATAGGTTATAGTGATGCAGTTACGCCTGGGCCAATAGATGCCCATTATCCCGTACTTCTTAGT
GATCTTCCTGCCCCTAAAATCCGTACTTATCCAATTTATACGGTAATTGCAGAAAAGCTGCACGCAATTGCATTATTGGG
CATGGCGAATAGTCGATTAAAAAACTACTTGGATCTTTATGTATTATTAGGTAATGAACAGATAGATAATCAAATCTTGG
CTAAAGCTATACAGGCCACATTTAATCGTCGAGGTATGGATCTTCCTGAAGCACTGCCTATTGGCCTGACCGATGAGTTT
GCTAACGACCCAAGCAGGGAGTCAATGTGGAAAGCCTTTTTGAGAAAAAATGAACTAGAGCAGAAACCATTAACTGAAGT
TATTGCTGTGATCAGAAATTTGATTCAAGTGCCATATTCTTTGGCAAAGTAA

Antitoxin


Download         Length: 203 a.a.        Molecular weight: 22989.06 Da        Isoelectric Point: 9.6557

>AT76392 WP_061401188.1 NZ_CP021283:c2573010-2572402 [Legionella pneumophila subsp. pneumophila]
MKIEVNNKQKVLQMASKTGVIRMSDLTKKGITRATISRLVSENKLEKLAPGLYCLPETEFSEKESLVIIASRVPQAVFCL
LTALQIHDLTTQLPRKVWIAMPKGSHAPKMDYPPLKMVQYSDEAFSEGIEIIESDNIKLRVYNRAKTIADCFKHRNKIGL
DVAIEALKEAYTKNKVIVDELWHYAKICRVANVMRPYIEAIQ

Download         Length: 609 bp

>AT76392 NZ_CP021283:c2573010-2572402 [Legionella pneumophila subsp. pneumophila]
ATGAAGATAGAGGTCAACAATAAACAAAAAGTTCTCCAGATGGCTAGTAAAACGGGCGTTATTAGAATGTCCGATCTGAC
CAAGAAGGGGATCACTAGAGCGACCATTTCAAGGCTTGTTAGCGAAAACAAACTTGAAAAACTCGCTCCTGGACTCTATT
GCCTGCCCGAGACTGAGTTTTCAGAAAAGGAAAGCCTGGTTATTATAGCAAGTCGAGTACCTCAAGCAGTGTTTTGCCTG
CTAACTGCTTTGCAGATTCATGATCTAACAACACAGCTACCTCGAAAAGTATGGATAGCTATGCCAAAAGGGAGTCATGC
GCCAAAAATGGATTATCCTCCGCTAAAAATGGTGCAATATTCAGATGAAGCCTTTAGTGAAGGAATTGAAATTATAGAAT
CAGATAATATTAAACTAAGGGTGTATAACCGTGCCAAGACAATTGCAGATTGTTTCAAACATCGCAATAAAATTGGACTT
GATGTGGCCATTGAAGCGCTCAAAGAGGCTTATACAAAAAATAAAGTCATAGTTGATGAACTATGGCATTATGCGAAAAT
TTGTCGCGTTGCAAACGTAATGCGTCCTTATATTGAGGCAATTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References