Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 2741031..2742487 Replicon chromosome
Accession NZ_CP021274
Organism Legionella pneumophila strain D-4040

Toxin (Protein)


Gene name rlegT Uniprot ID -
Locus tag CA938_RS12485 Protein ID WP_014842352.1
Coordinates 2741031..2741882 (-) Length 284 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID -
Locus tag CA938_RS12490 Protein ID WP_027265135.1
Coordinates 2741879..2742487 (-) Length 203 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA938_RS12450 2736222..2736575 - 354 WP_014842347.1 conjugal transfer transcriptional regulator TraJ -
CA938_RS12455 2736990..2737334 + 345 WP_014842348.1 TraK family protein -
CA938_RS12460 2737334..2738059 + 726 WP_014842349.1 conjugal transfer protein TraL -
CA938_RS12465 2738059..2738499 + 441 WP_042754801.1 conjugal transfer protein TraM -
CA938_RS12470 2738664..2739698 + 1035 WP_027265137.1 putative DNA binding domain-containing protein -
CA938_RS16665 2740442..2740522 - 81 WP_152027460.1 transposase -
CA938_RS12480 2740531..2740950 + 420 Protein_2413 DUF2779 domain-containing protein -
CA938_RS12485 2741031..2741882 - 852 WP_014842352.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
CA938_RS12490 2741879..2742487 - 609 WP_027265135.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
CA938_RS12495 2742730..2742993 + 264 WP_014842354.1 hypothetical protein -
CA938_RS12500 2742993..2743490 + 498 WP_106195098.1 hypothetical protein -
CA938_RS16755 2743846..2744007 - 162 WP_154080659.1 hypothetical protein -
CA938_RS12510 2744161..2744385 + 225 WP_106195101.1 hypothetical protein -
CA938_RS12515 2744454..2745308 + 855 WP_152030764.1 porin family protein -
CA938_RS12520 2745338..2746456 + 1119 WP_014842363.1 DUF3494 domain-containing protein -
CA938_RS16760 2746760..2746918 + 159 WP_154080660.1 hypothetical protein -
CA938_RS12525 2746966..2747307 + 342 WP_027265134.1 IS630 transposase-related protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(35-262)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(9-56)


Sequences

Toxin        


Download         Length: 284 a.a.        Molecular weight: 31702.65 Da        Isoelectric Point: 6.2785

>T76379 WP_014842352.1 NZ_CP021274:c2741882-2741031 [Legionella pneumophila]
MIKNIGESVRSRLKNIAVKEGSDFNAVLTRYGLERLLYRIGESEYSNQFLLKGALLFNLWYDMPHRPTKDIDLLGFGDND
LAYIKQTFSKICSIFADDGISFLSESVTVDTIKKDGGYTGARVELFGELAKAKIKIQIDIGYGDAVTPGPIDAHYPVLLS
DLPAPKIRTYPIYTVIAEKLHAIALLGMANGRLKDYLDLYVLLGNEQIDNQILAKAIQATFNRRGMDLPEALPIGLTDEF
ANDPSRESMWKAFLRKNELEQKPLTEVIAVIRNLIQVPYSLAK

Download         Length: 852 bp

>T76379 NZ_CP021274:c2741882-2741031 [Legionella pneumophila]
ATGATCAAAAATATTGGTGAGTCCGTACGCTCACGTTTGAAGAATATAGCTGTTAAAGAAGGTTCTGATTTTAATGCGGT
ATTGACTCGTTATGGTCTAGAGCGTTTGTTGTATCGAATTGGAGAATCAGAATATTCTAACCAGTTTTTGTTGAAAGGTG
CCTTACTGTTTAACCTATGGTACGACATGCCCCATCGCCCAACTAAAGATATTGATTTATTGGGATTTGGTGATAACGAT
CTGGCGTATATTAAGCAAACGTTCAGTAAAATTTGCAGCATCTTTGCAGATGATGGAATAAGTTTTCTGTCTGAATCAGT
GACGGTTGACACTATCAAAAAAGATGGAGGTTATACTGGAGCAAGAGTTGAGTTATTTGGGGAATTGGCGAAAGCAAAGA
TTAAAATACAAATTGATATAGGTTATGGTGATGCAGTTACGCCTGGGCCAATAGATGCCCATTATCCCGTACTTCTTAGT
GATCTTCCTGCCCCTAAAATCCGTACTTATCCAATTTATACGGTAATTGCAGAAAAGCTGCACGCAATTGCATTATTGGG
CATGGCGAATGGTCGATTAAAAGACTACTTGGATCTTTATGTATTATTAGGTAATGAACAGATAGATAATCAAATCTTGG
CTAAAGCTATACAAGCCACATTTAATCGTCGAGGTATGGATCTTCCTGAAGCACTGCCTATTGGCCTGACCGATGAGTTT
GCTAACGACCCAAGCAGGGAGTCAATGTGGAAAGCCTTTTTGAGAAAAAATGAACTAGAGCAGAAACCATTAACTGAAGT
CATTGCTGTGATCAGAAATTTGATTCAAGTGCCATATTCTTTGGCAAAGTAA

Antitoxin


Download         Length: 203 a.a.        Molecular weight: 22977.01 Da        Isoelectric Point: 9.6557

>AT76379 WP_027265135.1 NZ_CP021274:c2742487-2741879 [Legionella pneumophila]
MKTEVNNKQKVLQMASKTGVIRMSDLTKKGITRATISRLVSENKLEKLAPGLYCLPETEFSEKESLVIIASRVPQAVFCL
LTALQIHDLTTQLPRKVWIAMPKGSHAPKMDYPPLKMVQYSDEAFSEGIEIIESDNIKLRVYNRAKTIADCFKHRNKIGL
DVAIEALKEAYTKNKVIVDELWHYAKICRVANVMRPYIEAIQ

Download         Length: 609 bp

>AT76379 NZ_CP021274:c2742487-2741879 [Legionella pneumophila]
ATGAAGACAGAGGTCAACAATAAACAAAAAGTTCTCCAGATGGCTAGTAAAACGGGCGTTATTAGAATGTCCGATCTGAC
CAAGAAGGGGATCACTAGAGCGACCATTTCAAGGCTTGTTAGCGAAAACAAACTTGAAAAACTCGCTCCTGGACTCTATT
GCCTGCCCGAGACTGAGTTTTCAGAAAAGGAAAGCCTGGTTATTATAGCAAGTCGAGTACCTCAAGCAGTGTTTTGCCTG
CTAACTGCTTTGCAGATTCATGATCTAACAACACAGCTACCTCGAAAAGTATGGATAGCTATGCCAAAAGGGAGTCATGC
GCCAAAAATGGATTATCCTCCGCTAAAAATGGTGCAATATTCAGATGAAGCCTTTAGTGAAGGAATTGAAATTATAGAAT
CAGATAATATTAAACTAAGGGTGTATAACCGTGCCAAGACAATTGCAGATTGTTTCAAACATCGCAATAAAATTGGACTT
GATGTGGCCATTGAAGCGCTCAAAGAGGCTTATACAAAAAATAAAGTCATAGTTGATGAACTATGGCATTATGCGAAAAT
TTGTCGCGTTGCAAACGTAATGCGTCCTTATATTGAGGCAATTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References