Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 2736046..2737502 Replicon chromosome
Accession NZ_CP021272
Organism Legionella pneumophila strain D-5265

Toxin (Protein)


Gene name rlegT Uniprot ID -
Locus tag CA939_RS12485 Protein ID WP_061401155.1
Coordinates 2736046..2736897 (-) Length 284 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID -
Locus tag CA939_RS12490 Protein ID WP_061401188.1
Coordinates 2736894..2737502 (-) Length 203 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA939_RS12450 2731228..2731581 - 354 WP_061401159.1 conjugal transfer transcriptional regulator TraJ -
CA939_RS12455 2731996..2732340 + 345 WP_014842348.1 TraK family protein -
CA939_RS12460 2732340..2733065 + 726 WP_014842349.1 conjugal transfer protein TraL -
CA939_RS12465 2733065..2733505 + 441 WP_042754801.1 conjugal transfer protein TraM -
CA939_RS12470 2733670..2734287 + 618 WP_061401158.1 putative DNA binding domain-containing protein -
CA939_RS12475 2734429..2735127 + 699 WP_061401157.1 hypothetical protein -
CA939_RS16270 2735458..2735538 - 81 WP_072356411.1 transposase -
CA939_RS12480 2735547..2735966 + 420 Protein_2412 DUF2779 domain-containing protein -
CA939_RS12485 2736046..2736897 - 852 WP_061401155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
CA939_RS12490 2736894..2737502 - 609 WP_061401188.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
CA939_RS12495 2737745..2738032 + 288 WP_061401154.1 hypothetical protein -
CA939_RS12500 2738010..2738411 + 402 WP_061401153.1 hypothetical protein -
CA939_RS12515 2739175..2740323 + 1149 WP_061401150.1 outer membrane beta-barrel protein -
CA939_RS12520 2740353..2741471 + 1119 WP_061401149.1 DUF3494 domain-containing protein -
CA939_RS16340 2741775..2741933 + 159 WP_154694733.1 hypothetical protein -
CA939_RS12525 2741981..2742322 + 342 WP_061401148.1 IS630 transposase-related protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(35-262)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(9-56)


Sequences

Toxin        


Download         Length: 284 a.a.        Molecular weight: 31761.72 Da        Isoelectric Point: 6.7342

>T76377 WP_061401155.1 NZ_CP021272:c2736897-2736046 [Legionella pneumophila]
MIKNIGESVRSRLKNIAVKEGSDFNAVLTRYGLERLLYRIGESEYSNQFLLKGALLFNLWYDMPHRPTKDIDLLGFGDND
LAYIKQTFSKICSIFADDGISFLSESVTVDTIKKDGGYTGARVELFGELAKAKIKIQIDIGYSDAVTPGPIDAHYPVLLS
DLPAPKIRTYPIYTVIAEKLHAIALLGMANSRLKNYLDLYVLLGNEQIDNQILAKAIQATFNRRGMDLPEALPIGLTDEF
ANDPSRESMWKAFLRKNELEQKPLTEVIAVIRNLIQVPYSLAK

Download         Length: 852 bp

>T76377 NZ_CP021272:c2736897-2736046 [Legionella pneumophila]
ATGATCAAAAATATTGGTGAGTCCGTACGCTCACGTTTGAAGAATATAGCTGTTAAAGAAGGTTCTGATTTTAATGCGGT
ATTGACTCGTTATGGTCTAGAGCGTTTGTTGTATCGAATTGGAGAATCAGAATATTCTAACCAGTTTTTGTTGAAAGGTG
CCTTACTGTTTAACCTATGGTACGACATGCCCCATCGCCCAACTAAAGATATTGATTTATTGGGATTTGGTGATAACGAT
CTGGCGTATATTAAGCAAACGTTCAGTAAAATTTGCAGTATCTTTGCAGATGATGGAATAAGTTTTCTGTCTGAATCAGT
GACGGTTGACACTATCAAAAAAGATGGAGGTTATACTGGAGCAAGAGTTGAGTTATTTGGGGAATTGGCGAAAGCAAAGA
TTAAAATACAAATTGATATAGGTTATAGTGATGCAGTTACGCCTGGGCCAATAGATGCCCATTATCCCGTACTTCTTAGT
GATCTTCCTGCCCCTAAAATCCGTACTTATCCAATTTATACGGTAATTGCAGAAAAGCTGCACGCAATTGCATTATTGGG
CATGGCGAATAGTCGATTAAAAAACTACTTGGATCTTTATGTATTATTAGGTAATGAACAGATAGATAATCAAATCTTGG
CTAAAGCTATACAGGCCACATTTAATCGTCGAGGTATGGATCTTCCTGAAGCACTGCCTATTGGCCTGACCGATGAGTTT
GCTAACGACCCAAGCAGGGAGTCAATGTGGAAAGCCTTTTTGAGAAAAAATGAACTAGAGCAGAAACCATTAACTGAAGT
TATTGCTGTGATCAGAAATTTGATTCAAGTGCCATATTCTTTGGCAAAGTAA

Antitoxin


Download         Length: 203 a.a.        Molecular weight: 22989.06 Da        Isoelectric Point: 9.6557

>AT76377 WP_061401188.1 NZ_CP021272:c2737502-2736894 [Legionella pneumophila]
MKIEVNNKQKVLQMASKTGVIRMSDLTKKGITRATISRLVSENKLEKLAPGLYCLPETEFSEKESLVIIASRVPQAVFCL
LTALQIHDLTTQLPRKVWIAMPKGSHAPKMDYPPLKMVQYSDEAFSEGIEIIESDNIKLRVYNRAKTIADCFKHRNKIGL
DVAIEALKEAYTKNKVIVDELWHYAKICRVANVMRPYIEAIQ

Download         Length: 609 bp

>AT76377 NZ_CP021272:c2737502-2736894 [Legionella pneumophila]
ATGAAGATAGAGGTCAACAATAAACAAAAAGTTCTCCAGATGGCTAGTAAAACGGGCGTTATTAGAATGTCCGATCTGAC
CAAGAAGGGGATCACTAGAGCGACCATTTCAAGGCTTGTTAGCGAAAACAAACTTGAAAAACTCGCTCCTGGACTCTATT
GCCTGCCCGAGACTGAGTTTTCAGAAAAGGAAAGCCTGGTTATTATAGCAAGTCGAGTACCTCAAGCAGTGTTTTGCCTG
CTAACTGCTTTGCAGATTCATGATCTAACAACACAGCTACCTCGAAAAGTATGGATAGCTATGCCAAAAGGGAGTCATGC
GCCAAAAATGGATTATCCTCCGCTAAAAATGGTGCAATATTCAGATGAAGCCTTTAGTGAAGGAATTGAAATTATAGAAT
CAGATAATATTAAACTAAGGGTGTATAACCGTGCCAAGACAATTGCAGATTGTTTCAAACATCGCAATAAAATTGGACTT
GATGTGGCCATTGAAGCGCTCAAAGAGGCTTATACAAAAAATAAAGTCATAGTTGATGAACTATGGCATTATGCGAAAAT
TTGTCGCGTTGCAAACGTAATGCGTCCTTATATTGAGGCAATTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References