Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 16550..17148 Replicon plasmid unnamed
Accession NZ_CP021271
Organism Legionella pneumophila strain D-7787

Toxin (Protein)


Gene name hicA Uniprot ID Q5WRX3
Locus tag CA940_RS15255 Protein ID WP_011212625.1
Coordinates 16951..17148 (-) Length 66 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q5WRX4
Locus tag CA940_RS15250 Protein ID WP_011212624.1
Coordinates 16550..16954 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA940_RS15240 12218..12790 - 573 WP_059411244.1 recombinase family protein -
CA940_RS15245 12926..15931 + 3006 WP_059411246.1 Tn3 family transposase -
CA940_RS15250 16550..16954 - 405 WP_011212624.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CA940_RS15255 16951..17148 - 198 WP_011212625.1 type II toxin-antitoxin system HicA family toxin Toxin
CA940_RS15265 18020..18883 - 864 WP_052358007.1 DUF1738 domain-containing protein -
CA940_RS15570 19193..19354 - 162 WP_011212628.1 hypothetical protein -
CA940_RS15270 19927..20460 - 534 WP_011212629.1 hypothetical protein -
CA940_RS15275 21727..22017 + 291 WP_059411238.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..56208 56208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 66 a.a.        Molecular weight: 7403.75 Da        Isoelectric Point: 10.6519

>T76376 WP_011212625.1 NZ_CP021271:c17148-16951 [Legionella pneumophila]
MKSAEIIKIIERDGWVQCHQKGSHCQFKHPTKKGRVTVPHPKKDLPIKTVASIFKQAGINKEDIK

Download         Length: 198 bp

>T76376 NZ_CP021271:c17148-16951 [Legionella pneumophila]
ATGAAAAGCGCAGAAATAATAAAAATAATTGAACGCGATGGTTGGGTGCAATGTCATCAGAAAGGAAGTCATTGCCAATT
TAAACATCCCACCAAAAAGGGTAGGGTGACAGTACCTCATCCTAAAAAAGATTTACCTATAAAAACAGTGGCCAGTATCT
TTAAACAAGCTGGTATTAATAAGGAGGATATAAAATGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 15006.00 Da        Isoelectric Point: 4.5129

>AT76376 WP_011212624.1 NZ_CP021271:c16954-16550 [Legionella pneumophila]
MRYPVVIHKDEHSDFGVIVPDIPGCYSSGSTYDEALTNVIEAIECHLEGLLIDNEPLPVGTTIDRWINDEEFQGGVWAFV
DIDLSQISGKAKRINITMPERILSLIDLYAKNHAIKNRSSFLADAALSYMESHK

Download         Length: 405 bp

>AT76376 NZ_CP021271:c16954-16550 [Legionella pneumophila]
ATGAGATATCCTGTAGTAATACATAAAGACGAACATAGTGATTTTGGTGTAATTGTCCCTGATATTCCTGGATGCTATTC
TTCTGGTAGCACTTATGATGAAGCTTTAACTAACGTAATTGAGGCAATTGAATGCCATTTGGAAGGATTATTAATAGATA
ATGAGCCTCTTCCAGTTGGTACAACAATTGACCGATGGATTAATGATGAAGAGTTTCAGGGCGGGGTATGGGCATTTGTT
GACATTGATTTAAGCCAAATATCGGGTAAAGCAAAACGCATTAATATCACTATGCCAGAGCGCATTTTAAGCCTCATCGA
TCTGTATGCCAAAAACCATGCGATAAAAAATCGTTCCTCCTTTTTGGCCGATGCAGCTCTGAGTTATATGGAAAGTCATA
AGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0VJ23

Antitoxin

Source ID Structure
AlphaFold DB Q5WRX4

References