Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prpT-prpA/CC2985(antitoxin)
Location 2331150..2331690 Replicon chromosome
Accession NZ_CP021269
Organism Legionella pneumophila subsp. pneumophila strain Bellingham

Toxin (Protein)


Gene name PrpT Uniprot ID -
Locus tag CA920_RS10655 Protein ID WP_014844324.1
Coordinates 2331394..2331690 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name PrpA Uniprot ID -
Locus tag CA920_RS10650 Protein ID WP_027224835.1
Coordinates 2331150..2331404 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA920_RS10630 2327054..2328229 - 1176 WP_027224832.1 ISL3 family transposase -
CA920_RS10635 2328268..2329398 - 1131 WP_064319116.1 ISL3 family transposase -
CA920_RS10640 2329553..2330131 + 579 WP_027224833.1 hypothetical protein -
CA920_RS10645 2330236..2330802 + 567 WP_027224834.1 hypothetical protein -
CA920_RS10650 2331150..2331404 + 255 WP_027224835.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
CA920_RS10655 2331394..2331690 + 297 WP_014844324.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CA920_RS10665 2332151..2333165 - 1015 Protein_2058 transposase -
CA920_RS10670 2333428..2333637 + 210 WP_010947832.1 cold-shock protein -
CA920_RS10675 2333877..2335283 + 1407 WP_014844326.1 ATP-dependent RNA helicase DbpA -
CA920_RS10680 2335440..2336351 + 912 WP_014844327.1 cation diffusion facilitator family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2325650..2337763 12113


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-94)

Antitoxin

Antitoxin ParD

(1-81)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11582.28 Da        Isoelectric Point: 7.2728

>T76373 WP_014844324.1 NZ_CP021269:2331394-2331690 [Legionella pneumophila subsp. pneumophila]
MSNKTYRLYPKAVEDLESIYLYSTNEFGIKRTEDYILAIDLSFQRLADDPLIARKCDYIRPELRAFNVGSHIIFFKTTDY
GISVIRVLHQSMDFNRHL

Download         Length: 297 bp

>T76373 NZ_CP021269:2331394-2331690 [Legionella pneumophila subsp. pneumophila]
ATGTCAAATAAAACATATCGTCTTTACCCAAAAGCGGTAGAAGATCTTGAGTCCATCTATTTATATAGCACAAATGAGTT
TGGTATCAAACGAACAGAGGATTATATTTTAGCTATAGATTTAAGTTTTCAGCGCCTTGCAGATGATCCCTTAATTGCTC
GAAAATGTGATTATATTCGTCCAGAATTACGCGCATTTAATGTTGGCTCTCACATTATTTTTTTCAAAACTACCGATTAC
GGCATTTCTGTTATTCGAGTGTTGCATCAATCTATGGATTTTAATAGACATCTATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9786.14 Da        Isoelectric Point: 9.9613

>AT76373 WP_027224835.1 NZ_CP021269:2331150-2331404 [Legionella pneumophila subsp. pneumophila]
MTRTMTVDLGNELRNYVESLVRSGDYRSNSEVLRESLRLLREKQAESKLEQLRHLIDEGAASGKPETWDAHDFLKKMKKK
SHVK

Download         Length: 255 bp

>AT76373 NZ_CP021269:2331150-2331404 [Legionella pneumophila subsp. pneumophila]
ATGACCCGTACAATGACTGTTGATTTGGGTAATGAACTTCGTAATTACGTGGAATCACTTGTACGCTCAGGGGATTATAG
AAGTAATAGCGAAGTATTAAGAGAGTCGTTGCGTTTACTTCGTGAAAAACAAGCTGAATCAAAACTAGAGCAGTTGCGTC
ACCTTATAGATGAAGGGGCAGCTAGCGGGAAGCCTGAAACATGGGATGCACATGATTTTCTTAAGAAAATGAAGAAAAAA
TCCCATGTCAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References