Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 70008..71545 Replicon chromosome
Accession NZ_CP021269
Organism Legionella pneumophila subsp. pneumophila strain Bellingham

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CA920_RS00335 Protein ID WP_032829405.1
Coordinates 70008..71312 (-) Length 435 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CA920_RS00340 Protein ID WP_014840730.1
Coordinates 71306..71545 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA920_RS00310 65570..66811 + 1242 WP_061692303.1 protein SdbC -
CA920_RS00315 67114..67518 - 405 WP_010945819.1 MerR family transcriptional regulator -
CA920_RS00320 67588..68340 + 753 WP_106202069.1 glutaredoxin family protein -
CA920_RS00325 68530..69621 + 1092 WP_027224672.1 hypothetical protein -
CA920_RS00330 69663..69938 + 276 Protein_62 integrase -
CA920_RS00335 70008..71312 - 1305 WP_032829405.1 type II toxin-antitoxin system HipA family toxin Toxin
CA920_RS00340 71306..71545 - 240 WP_014840730.1 helix-turn-helix domain-containing protein Antitoxin
CA920_RS00345 71912..72276 + 365 Protein_65 protein LvrA -
CA920_RS00350 72386..72658 + 273 WP_032829407.1 hypothetical protein -
CA920_RS00360 73353..74765 - 1413 WP_027224675.1 hypothetical protein -
CA920_RS00365 74796..75404 - 609 WP_027224676.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 435 a.a.        Molecular weight: 49704.13 Da        Isoelectric Point: 8.2954

>T76372 WP_032829405.1 NZ_CP021269:c71312-70008 [Legionella pneumophila subsp. pneumophila]
MVMRKLYILMNNELVGELTQDNAGGLSFSYVADWISKPHSRPVSLSLPLVNQKFSGEVVYNFFDNLLPDNPQIRARIQAR
FQAKSSRPFDLLALIGSDCVGAIQIVERIPQTQRLSIESHVVSEAEIARTLRSYQTSPLGMDKEDDEFRISIAGAQEKTA
FLYYQNEWHKPFGPTPTTHIFKLPIGYLPHQGIDLSESCENEHLCLLLASKFGLDVAKSKILQFEDEKVLVVERFDRKWS
RDNRYILRLPQEDLCQALGYSPNLKYQSDGGPGIKEIMQLLNGSQQPQKDRDEFFRAQVVYWCLGAIDAHAKNFSISIQP
QGGYQLTPLYDIISAYPIVEQKQLSFKKLKMAMALYGKNIHYKIDGIQKRHFIETAKYVKYSKIKAAQIFEQVIDRIDSA
IDEVSRQLPNHFPEKIADPIFKGMRAFKERMIST

Download         Length: 1305 bp

>T76372 NZ_CP021269:c71312-70008 [Legionella pneumophila subsp. pneumophila]
ATGGTAATGCGTAAATTATACATATTGATGAACAATGAGCTCGTGGGGGAGCTTACCCAGGATAATGCAGGTGGTTTGAG
TTTTTCCTACGTTGCTGACTGGATTTCCAAACCGCATTCACGCCCAGTTTCTTTATCGTTACCGTTAGTAAATCAAAAAT
TTTCAGGAGAAGTTGTTTATAACTTTTTTGATAATTTACTTCCCGATAATCCACAGATAAGAGCCAGAATTCAAGCTCGT
TTTCAGGCAAAATCATCGCGACCGTTTGATTTATTGGCGTTAATTGGCAGTGATTGTGTTGGTGCAATACAAATTGTTGA
ACGTATTCCTCAGACACAGCGTCTAAGCATTGAAAGTCACGTTGTCAGTGAGGCCGAGATAGCTCGTACTTTACGTTCTT
ACCAAACCTCACCACTGGGAATGGATAAAGAGGATGATGAGTTTAGAATCTCAATAGCCGGTGCTCAGGAAAAAACGGCT
TTTCTATATTACCAAAATGAATGGCATAAACCATTTGGACCTACACCAACAACTCACATATTCAAATTACCTATTGGATA
TTTACCACATCAAGGAATTGATTTAAGTGAGAGTTGTGAAAATGAGCATCTCTGTTTACTACTAGCCAGCAAATTTGGTT
TAGATGTTGCAAAATCAAAAATCTTACAATTCGAAGATGAAAAAGTGCTGGTTGTCGAAAGATTTGATAGAAAATGGAGT
CGAGATAACCGTTATATACTCAGGTTACCGCAAGAAGACCTATGCCAAGCGTTGGGTTATTCACCAAATTTAAAATATCA
GTCAGATGGTGGCCCCGGTATTAAAGAAATTATGCAGCTACTTAATGGCTCACAGCAGCCTCAAAAAGACAGAGATGAAT
TTTTCAGAGCACAAGTTGTTTACTGGTGCCTTGGTGCTATTGATGCGCATGCCAAAAATTTCAGTATAAGTATACAACCA
CAAGGCGGTTACCAGCTCACCCCCTTATACGACATCATTTCAGCCTATCCTATCGTGGAACAAAAACAGCTATCCTTTAA
GAAATTGAAAATGGCAATGGCTTTATATGGTAAAAATATTCATTACAAGATTGACGGTATTCAAAAAAGACACTTTATTG
AAACAGCAAAATACGTTAAATATTCTAAAATTAAAGCAGCTCAGATTTTTGAACAAGTGATTGACCGTATTGATTCTGCT
ATCGATGAGGTCTCAAGACAATTACCAAACCACTTCCCAGAAAAGATTGCAGATCCAATCTTCAAAGGGATGAGAGCTTT
TAAGGAGCGAATGATATCCACATAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9096.40 Da        Isoelectric Point: 5.0774

>AT76372 WP_014840730.1 NZ_CP021269:c71545-71306 [Legionella pneumophila subsp. pneumophila]
MIISSAKDLALYLNDKRKQLKMSQSEVADLVGLKQDTISKFENSPDNSRIDTLFRILSALNLNMSLVEKDQKTHEEIEW

Download         Length: 240 bp

>AT76372 NZ_CP021269:c71545-71306 [Legionella pneumophila subsp. pneumophila]
ATGATCATTAGCTCAGCAAAAGATTTAGCATTATATTTAAATGACAAGCGCAAACAACTCAAAATGAGTCAATCTGAAGT
TGCCGATTTAGTCGGCTTAAAACAGGATACCATATCAAAGTTTGAAAATAGCCCCGATAATAGTCGAATTGATACCTTAT
TTAGAATATTGTCCGCCCTAAATTTAAATATGAGCCTTGTTGAAAAAGATCAAAAAACTCATGAAGAGATAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References