Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 3325131..3325668 Replicon chromosome
Accession NZ_CP021266
Organism Legionella pneumophila subsp. pneumophila strain Knoxville

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag CA925_RS15005 Protein ID WP_027266055.1
Coordinates 3325131..3325427 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CA925_RS15010 Protein ID WP_027266056.1
Coordinates 3325417..3325668 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA925_RS14975 3321223..3322119 - 897 WP_027266053.1 hypothetical protein -
CA925_RS14980 3322387..3322578 + 192 WP_014327021.1 hypothetical protein -
CA925_RS14990 3323049..3323588 - 540 WP_062730332.1 sel1 repeat family protein -
CA925_RS14995 3323548..3324201 - 654 WP_027266054.1 hypothetical protein -
CA925_RS15000 3324560..3325042 - 483 WP_014842908.1 hypothetical protein -
CA925_RS15005 3325131..3325427 - 297 WP_027266055.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CA925_RS15010 3325417..3325668 - 252 WP_027266056.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CA925_RS15015 3325832..3327037 + 1206 WP_061638482.1 ISNCY family transposase -
CA925_RS15020 3327210..3327949 - 740 Protein_2892 site-specific integrase -
CA925_RS15025 3327988..3329127 - 1140 WP_134984249.1 DUF3800 domain-containing protein -
CA925_RS15710 3329245..3329610 - 366 WP_197697735.1 recombinase family protein -
CA925_RS15715 3329592..3329789 - 198 WP_197697736.1 recombinase family protein -
CA925_RS15590 3329877..3330017 + 141 WP_154219844.1 hypothetical protein -
CA925_RS15035 3330042..3330545 - 504 WP_027265579.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-60)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11512.36 Da        Isoelectric Point: 10.3916

>T76366 WP_027266055.1 NZ_CP021266:c3325427-3325131 [Legionella pneumophila subsp. pneumophila]
MIYELHFHPLALKEWKKLGKNLQEEFKKVLKRRLENPHVASASLRGSLKNCYKIKLRQSGYRLVYQVNDNKLIVTVIAVG
KRNKNVVYDDADNRQEDS

Download         Length: 297 bp

>T76366 NZ_CP021266:c3325427-3325131 [Legionella pneumophila subsp. pneumophila]
ATGATTTATGAGCTTCATTTTCATCCTTTAGCTTTAAAAGAATGGAAAAAGCTGGGGAAAAACCTTCAAGAAGAATTTAA
GAAAGTGTTAAAACGCCGTTTAGAAAATCCACATGTGGCTTCGGCTAGCTTAAGAGGCTCTTTAAAAAATTGCTATAAAA
TAAAATTACGTCAATCTGGTTATCGTTTGGTGTATCAAGTTAATGATAATAAATTAATTGTAACCGTCATAGCAGTCGGG
AAAAGAAACAAAAATGTTGTCTATGATGATGCAGATAACCGACAAGAAGACAGTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.70 Da        Isoelectric Point: 5.0359

>AT76366 WP_027266056.1 NZ_CP021266:c3325668-3325417 [Legionella pneumophila subsp. pneumophila]
MQTLFATQVASISELKKNPTKLINDAHGKPVAILNHNTAAAYLIPVETFEKLMDLIDENELHKIVEERLSAPFTSIKVNI
DDL

Download         Length: 252 bp

>AT76366 NZ_CP021266:c3325668-3325417 [Legionella pneumophila subsp. pneumophila]
ATGCAAACTTTATTTGCTACACAAGTAGCGAGCATTAGTGAATTAAAAAAGAACCCCACTAAGCTCATTAATGATGCTCA
TGGAAAACCTGTTGCTATTCTTAACCACAATACAGCGGCAGCATATTTAATTCCTGTTGAAACATTTGAAAAACTAATGG
ATTTGATTGATGAGAATGAACTACATAAAATAGTAGAAGAGCGTTTGTCAGCACCTTTTACCTCAATAAAGGTAAATATT
GATGATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References