Detailed information of TA system TA076366

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 3325131..3325668
• Replicon: chromosome
• Accession: NZ_CP021266
• Organism: Legionella pneumophila subsp. pneumophila strain Knoxville

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CA925_RS15005
• Protein ID: WP_027266055.1
• Coordinates: 3325131..3325427 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CA925_RS15010
• Protein ID: WP_027266056.1
• Coordinates: 3325417..3325668 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CA925_RS14975	3321223..3322119	-	897	WP_027266053.1	hypothetical protein	-
CA925_RS14980	3322387..3322578	+	192	WP_014327021.1	hypothetical protein	-
CA925_RS14990	3323049..3323588	-	540	WP_062730332.1	sel1 repeat family protein	-
CA925_RS14995	3323548..3324201	-	654	WP_027266054.1	hypothetical protein	-
CA925_RS15000	3324560..3325042	-	483	WP_014842908.1	hypothetical protein	-
CA925_RS15005	3325131..3325427	-	297	WP_027266055.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CA925_RS15010	3325417..3325668	-	252	WP_027266056.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
CA925_RS15015	3325832..3327037	+	1206	WP_061638482.1	ISNCY family transposase	-
CA925_RS15020	3327210..3327949	-	740	Protein_2892	site-specific integrase	-
CA925_RS15025	3327988..3329127	-	1140	WP_134984249.1	DUF3800 domain-containing protein	-
CA925_RS15710	3329245..3329610	-	366	WP_197697735.1	recombinase family protein	-
CA925_RS15715	3329592..3329789	-	198	WP_197697736.1	recombinase family protein	-
CA925_RS15590	3329877..3330017	+	141	WP_154219844.1	hypothetical protein	-
CA925_RS15035	3330042..3330545	-	504	WP_027265579.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-60)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11512.36 Da
• Isoelectric Point: 10.3916

>T76366 WP_027266055.1 NZ_CP021266:c3325427-3325131 [Legionella pneumophila subsp. pneumophila]
MIYELHFHPLALKEWKKLGKNLQEEFKKVLKRRLENPHVASASLRGSLKNCYKIKLRQSGYRLVYQVNDNKLIVTVIAVG
KRNKNVVYDDADNRQEDS

Nucleotide

• Length: 297 bp

>T76366 NZ_CP021266:c3325427-3325131 [Legionella pneumophila subsp. pneumophila]
ATGATTTATGAGCTTCATTTTCATCCTTTAGCTTTAAAAGAATGGAAAAAGCTGGGGAAAAACCTTCAAGAAGAATTTAA
GAAAGTGTTAAAACGCCGTTTAGAAAATCCACATGTGGCTTCGGCTAGCTTAAGAGGCTCTTTAAAAAATTGCTATAAAA
TAAAATTACGTCAATCTGGTTATCGTTTGGTGTATCAAGTTAATGATAATAAATTAATTGTAACCGTCATAGCAGTCGGG
AAAAGAAACAAAAATGTTGTCTATGATGATGCAGATAACCGACAAGAAGACAGTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9271.70 Da
• Isoelectric Point: 5.0359

>AT76366 WP_027266056.1 NZ_CP021266:c3325668-3325417 [Legionella pneumophila subsp. pneumophila]
MQTLFATQVASISELKKNPTKLINDAHGKPVAILNHNTAAAYLIPVETFEKLMDLIDENELHKIVEERLSAPFTSIKVNI
DDL

Nucleotide

• Length: 252 bp

>AT76366 NZ_CP021266:c3325668-3325417 [Legionella pneumophila subsp. pneumophila]
ATGCAAACTTTATTTGCTACACAAGTAGCGAGCATTAGTGAATTAAAAAAGAACCCCACTAAGCTCATTAATGATGCTCA
TGGAAAACCTGTTGCTATTCTTAACCACAATACAGCGGCAGCATATTTAATTCCTGTTGAAACATTTGAAAAACTAATGG
ATTTGATTGATGAGAATGAACTACATAAAATAGTAGAAGAGCGTTTGTCAGCACCTTTTACCTCAATAAAGGTAAATATT
GATGATTTATGA