Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 2778946..2780402 Replicon chromosome
Accession NZ_CP021261
Organism Legionella pneumophila strain NY23 (D-7705)

Toxin (Protein)


Gene name rlegT Uniprot ID -
Locus tag CA932_RS12610 Protein ID WP_062728144.1
Coordinates 2778946..2779797 (-) Length 284 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID -
Locus tag CA932_RS12615 Protein ID WP_062728146.1
Coordinates 2779794..2780402 (-) Length 203 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA932_RS12595 2773963..2775294 + 1332 WP_027265129.1 Na+/H+ antiporter NhaA -
CA932_RS12600 2776246..2777421 - 1176 WP_106174730.1 ISL3 family transposase -
CA932_RS12605 2777729..2778763 + 1035 WP_062728145.1 hypothetical protein -
CA932_RS12610 2778946..2779797 - 852 WP_062728144.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
CA932_RS12615 2779794..2780402 - 609 WP_062728146.1 AbiEi antitoxin N-terminal domain-containing protein Antitoxin
CA932_RS12620 2780795..2781970 - 1176 WP_106174732.1 ISL3 family transposase -
CA932_RS12625 2782200..2782913 + 714 WP_152027454.1 hypothetical protein -
CA932_RS12630 2782973..2783170 - 198 Protein_2451 hypothetical protein -
CA932_RS12635 2783218..2783529 - 312 WP_062728338.1 cupin -
CA932_RS12640 2783545..2784837 - 1293 WP_062740169.1 ATP-grasp domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(35-263)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(9-55)


Sequences

Toxin        


Download         Length: 284 a.a.        Molecular weight: 31721.71 Da        Isoelectric Point: 6.7346

>T76354 WP_062728144.1 NZ_CP021261:c2779797-2778946 [Legionella pneumophila]
MTKNIGESVRSRLKNIAIKEGSDLNAVLTRYGLERLLYRIGESEYSNQFLLKGALLFNLWYDMPHRPTKDIDLLGFGDND
LASIKQTFSKICSISVDDGISFLSESVTVDSIKKDGDYTGARVELFGELAKAKIKIQIDIGYGDAVTPGPIDAHYPVLLS
DLPAPKIRTYPIYTVIAEKLHAIAFLGMANSRLKDYLDLYVLLSKEQLNNQVLAKAIQATFTRRGMTVPEALPIGLTDEF
ANDPTRESMWIAFLRKNELEQKPLSEVIAVIRNLIQMPFSFVK

Download         Length: 852 bp

>T76354 NZ_CP021261:c2779797-2778946 [Legionella pneumophila]
ATGACAAAAAATATTGGTGAGTCTGTGCGCTCACGTTTGAAGAATATAGCTATAAAAGAAGGTTCTGATTTAAACGCGGT
ATTAACTCGTTACGGATTAGAACGTTTGTTATATCGAATTGGAGAATCAGAATACTCTAATCAGTTTTTATTGAAAGGGG
CTTTACTATTTAACCTATGGTATGACATGCCCCATCGCCCAACTAAAGATATTGATTTATTGGGGTTTGGTGATAATGAT
CTAGCGTCTATTAAACAAACATTCAGTAAAATTTGCAGTATCTCAGTAGATGATGGAATAAGTTTTCTTTCGGAATCAGT
GACAGTAGACTCTATTAAAAAAGATGGGGATTATACTGGAGCAAGAGTTGAGTTATTTGGGGAGTTGGCGAAAGCAAAGA
TCAAAATACAAATTGATATTGGTTATGGTGATGCAGTTACCCCAGGACCAATAGACGCCCATTATCCTGTTCTTCTTAGT
GATCTACCTGCCCCTAAAATCCGCACCTATCCAATTTATACGGTAATTGCAGAAAAGCTGCACGCAATTGCATTCTTGGG
CATGGCGAATAGTCGATTAAAAGACTACTTGGATCTTTATGTATTATTAAGTAAAGAGCAGTTGAATAATCAAGTCTTGG
CTAAAGCAATACAAGCTACATTTACTCGCCGAGGCATGACAGTTCCAGAGGCTTTACCAATTGGCCTAACCGATGAGTTT
GCCAATGATCCAACTAGAGAATCAATGTGGATAGCTTTTTTGAGAAAGAATGAATTAGAGCAAAAGCCATTATCAGAAGT
AATTGCTGTGATCAGAAATTTGATCCAAATGCCATTCTCTTTTGTAAAATAA

Antitoxin


Download         Length: 203 a.a.        Molecular weight: 22967.88 Da        Isoelectric Point: 9.2687

>AT76354 WP_062728146.1 NZ_CP021261:c2780402-2779794 [Legionella pneumophila]
MKTKDSYKQKVLQMASKTGIVRMSDLTEMGITRATISRLVSENKLEKLASGLYCLSETELSEKESLVIIASRVPQAVFCL
LTALQIHDLTTQLPRKVWIAMPKGSHAPKMDYPPLKMVQYSDEAFSEGIEIIESDNIKLRVYNRAKTIADCFKHRNKIGI
DVAIEALKEAYSKNKVTVDELWHYAKICRVANVMRPYIETIQ

Download         Length: 609 bp

>AT76354 NZ_CP021261:c2780402-2779794 [Legionella pneumophila]
ATGAAGACAAAGGATAGCTATAAACAAAAAGTACTCCAGATGGCTAGTAAAACGGGCATTGTTCGAATGTCCGATCTAAC
CGAAATGGGGATCACTAGAGCGACTATTTCAAGGCTTGTTAGCGAAAACAAACTTGAAAAACTCGCTTCTGGGCTCTATT
GCTTGTCAGAGACTGAGCTTTCAGAAAAAGAAAGCCTGGTTATTATAGCAAGCCGAGTACCTCAAGCAGTGTTTTGCCTT
CTAACTGCTTTGCAGATTCATGATCTAACAACACAGCTACCTCGAAAAGTATGGATAGCTATGCCAAAAGGGAGTCATGC
GCCAAAAATGGATTATCCCCCGCTAAAAATGGTGCAATATTCCGATGAAGCCTTTAGTGAAGGAATTGAAATTATAGAAT
CAGATAATATTAAACTAAGAGTGTATAACCGTGCCAAGACAATTGCGGATTGTTTCAAACATCGCAATAAAATTGGCATT
GATGTCGCTATTGAAGCACTCAAAGAAGCTTATTCAAAAAATAAAGTAACAGTTGATGAACTATGGCATTATGCGAAAAT
TTGTCGCGTTGCAAACGTAATGCGTCCTTATATTGAGACAATTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References