Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 2785131..2786587 Replicon chromosome
Accession NZ_CP021260
Organism Legionella pneumophila strain NY24 (D-7706)

Toxin (Protein)


Gene name rlegT Uniprot ID -
Locus tag CA933_RS12655 Protein ID WP_014842352.1
Coordinates 2785131..2785982 (-) Length 284 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID -
Locus tag CA933_RS12660 Protein ID WP_027265135.1
Coordinates 2785979..2786587 (-) Length 203 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA933_RS12625 2780322..2780675 - 354 WP_014842347.1 conjugal transfer transcriptional regulator TraJ -
CA933_RS12630 2781090..2781434 + 345 WP_014842348.1 TraK family protein -
CA933_RS12635 2781434..2782159 + 726 WP_014842349.1 conjugal transfer protein TraL -
CA933_RS12640 2782159..2782599 + 441 WP_014842350.1 conjugal transfer protein TraM -
CA933_RS12645 2782764..2783798 + 1035 WP_027265137.1 putative DNA binding domain-containing protein -
CA933_RS16370 2784542..2784622 - 81 WP_072356411.1 transposase -
CA933_RS12650 2784631..2785050 + 420 Protein_2455 DUF2779 domain-containing protein -
CA933_RS12655 2785131..2785982 - 852 WP_014842352.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
CA933_RS12660 2785979..2786587 - 609 WP_027265135.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
CA933_RS12665 2786830..2787093 + 264 WP_014842354.1 hypothetical protein -
CA933_RS12670 2787093..2787743 + 651 WP_014842355.1 DUF3800 domain-containing protein -
CA933_RS12675 2787892..2789979 + 2088 WP_014842356.1 hypothetical protein -
CA933_RS12680 2789981..2790361 - 381 WP_014842357.1 hypothetical protein -
CA933_RS12685 2790581..2791141 - 561 WP_014842358.1 recombinase family protein -
CA933_RS12690 2791152..2791469 - 318 WP_014842359.1 DUF2442 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2790581..2791141 560


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(35-262)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(9-56)


Sequences

Toxin        


Download         Length: 284 a.a.        Molecular weight: 31702.65 Da        Isoelectric Point: 6.2785

>T76351 WP_014842352.1 NZ_CP021260:c2785982-2785131 [Legionella pneumophila]
MIKNIGESVRSRLKNIAVKEGSDFNAVLTRYGLERLLYRIGESEYSNQFLLKGALLFNLWYDMPHRPTKDIDLLGFGDND
LAYIKQTFSKICSIFADDGISFLSESVTVDTIKKDGGYTGARVELFGELAKAKIKIQIDIGYGDAVTPGPIDAHYPVLLS
DLPAPKIRTYPIYTVIAEKLHAIALLGMANGRLKDYLDLYVLLGNEQIDNQILAKAIQATFNRRGMDLPEALPIGLTDEF
ANDPSRESMWKAFLRKNELEQKPLTEVIAVIRNLIQVPYSLAK

Download         Length: 852 bp

>T76351 NZ_CP021260:c2785982-2785131 [Legionella pneumophila]
ATGATCAAAAATATTGGTGAGTCCGTACGCTCACGTTTGAAGAATATAGCTGTTAAAGAAGGTTCTGATTTTAATGCGGT
ATTGACTCGTTATGGTCTAGAGCGTTTGTTGTATCGAATTGGAGAATCAGAATATTCTAACCAGTTTTTGTTGAAAGGTG
CCTTACTGTTTAACCTATGGTACGACATGCCCCATCGCCCAACTAAAGATATTGATTTATTGGGATTTGGTGATAACGAT
CTGGCGTATATTAAGCAAACGTTCAGTAAAATTTGCAGCATCTTTGCAGATGATGGAATAAGTTTTCTGTCTGAATCAGT
GACGGTTGACACTATCAAAAAAGATGGAGGTTATACTGGAGCAAGAGTTGAGTTATTTGGGGAATTGGCGAAAGCAAAGA
TTAAAATACAAATTGATATAGGTTATGGTGATGCAGTTACGCCTGGGCCAATAGATGCCCATTATCCCGTACTTCTTAGT
GATCTTCCTGCCCCTAAAATCCGTACTTATCCAATTTATACGGTAATTGCAGAAAAGCTGCACGCAATTGCATTATTGGG
CATGGCGAATGGTCGATTAAAAGACTACTTGGATCTTTATGTATTATTAGGTAATGAACAGATAGATAATCAAATCTTGG
CTAAAGCTATACAAGCCACATTTAATCGTCGAGGTATGGATCTTCCTGAAGCACTGCCTATTGGCCTGACCGATGAGTTT
GCTAACGACCCAAGCAGGGAGTCAATGTGGAAAGCCTTTTTGAGAAAAAATGAACTAGAGCAGAAACCATTAACTGAAGT
CATTGCTGTGATCAGAAATTTGATTCAAGTGCCATATTCTTTGGCAAAGTAA

Antitoxin


Download         Length: 203 a.a.        Molecular weight: 22977.01 Da        Isoelectric Point: 9.6557

>AT76351 WP_027265135.1 NZ_CP021260:c2786587-2785979 [Legionella pneumophila]
MKTEVNNKQKVLQMASKTGVIRMSDLTKKGITRATISRLVSENKLEKLAPGLYCLPETEFSEKESLVIIASRVPQAVFCL
LTALQIHDLTTQLPRKVWIAMPKGSHAPKMDYPPLKMVQYSDEAFSEGIEIIESDNIKLRVYNRAKTIADCFKHRNKIGL
DVAIEALKEAYTKNKVIVDELWHYAKICRVANVMRPYIEAIQ

Download         Length: 609 bp

>AT76351 NZ_CP021260:c2786587-2785979 [Legionella pneumophila]
ATGAAGACAGAGGTCAACAATAAACAAAAAGTTCTCCAGATGGCTAGTAAAACGGGCGTTATTAGAATGTCCGATCTGAC
CAAGAAGGGGATCACTAGAGCGACCATTTCAAGGCTTGTTAGCGAAAACAAACTTGAAAAACTCGCTCCTGGACTCTATT
GCCTGCCCGAGACTGAGTTTTCAGAAAAGGAAAGCCTGGTTATTATAGCAAGTCGAGTACCTCAAGCAGTGTTTTGCCTG
CTAACTGCTTTGCAGATTCATGATCTAACAACACAGCTACCTCGAAAAGTATGGATAGCTATGCCAAAAGGGAGTCATGC
GCCAAAAATGGATTATCCTCCGCTAAAAATGGTGCAATATTCAGATGAAGCCTTTAGTGAAGGAATTGAAATTATAGAAT
CAGATAATATTAAACTAAGGGTGTATAACCGTGCCAAGACAATTGCAGATTGTTTCAAACATCGCAATAAAATTGGACTT
GATGTGGCCATTGAAGCGCTCAAAGAGGCTTATACAAAAAATAAAGTCATAGTTGATGAACTATGGCATTATGCGAAAAT
TTGTCGCGTTGCAAACGTAATGCGTCCTTATATTGAGGCAATTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References