Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2688907..2690341 Replicon chromosome
Accession NZ_CP021259
Organism Legionella pneumophila strain D-7708

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag CA934_RS12165 Protein ID WP_106225649.1
Coordinates 2689121..2690341 (+) Length 407 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag CA934_RS12160 Protein ID WP_027227407.1
Coordinates 2688907..2689134 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA934_RS12150 2686347..2687213 - 867 WP_106225648.1 transposase -
CA934_RS12155 2687424..2688125 + 702 Protein_2355 ISAs1 family transposase -
CA934_RS12160 2688907..2689134 + 228 WP_027227407.1 helix-turn-helix transcriptional regulator Antitoxin
CA934_RS12165 2689121..2690341 + 1221 WP_106225649.1 type II toxin-antitoxin system HipA family toxin Toxin
CA934_RS12170 2690374..2691495 - 1122 WP_061504501.1 ISAs1 family transposase -
CA934_RS12175 2691612..2691968 - 357 WP_106225938.1 preprotein translocase -
CA934_RS12180 2692008..2692913 - 906 WP_106225650.1 LysR family transcriptional regulator -
CA934_RS12185 2693004..2693864 + 861 WP_106225651.1 DUF2608 domain-containing protein -
CA934_RS12190 2694216..2694480 - 265 Protein_2362 hypothetical protein -
CA934_RS12195 2694528..2694839 - 312 WP_027227411.1 cupin -
CA934_RS12200 2694855..2695103 - 249 WP_031301595.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-104)

Antitoxin

Transcription regulator, HipB-like

(7-63)


Sequences

Toxin        


Download         Length: 407 a.a.        Molecular weight: 45390.54 Da        Isoelectric Point: 8.3174

>T76349 WP_106225649.1 NZ_CP021259:2689121-2690341 [Legionella pneumophila]
MKNHKLDVYLNQTLTGQLRIDTHGEMSFVYDEGYLENNKNLPLSHSLPLQQAPYSTKQCRPFFSGLLPEAHMRTAIARQL
GISEKNDFALLAAIGGECAGAVMILPQDTSITQLKPDYKIIKKQDVLEILQTMHQRPMIVGEDGIRLSLAGAQDKLPVAI
IEGNLAIPMNGAPSTHILKPINRDFPSLIENESFCLNLAQKIGLNAVDASIHYADGTPYLLVKRYDRVETKQGIQRLHQE
DFCQAMGISPEMKYQREGGPQISECFGLIREISSLPVLDIKELLQGILFNVIIGNNDAHSKNFSLLYHGSKVRLAPFYDL
ISTVYYPNLASKMAMKVGSKYDFDGLFPRHFIQMAEEARLSGALVRKEVLNLISKIQKNITASPFTSIILQRADKLFQKF
QKASTG

Download         Length: 1221 bp

>T76349 NZ_CP021259:2689121-2690341 [Legionella pneumophila]
ATGAAAAATCATAAACTTGATGTCTATCTTAACCAAACACTAACAGGCCAATTACGTATCGATACGCATGGCGAGATGTC
TTTTGTGTATGATGAAGGCTACCTGGAAAACAATAAAAATCTCCCGTTGTCACACTCCCTTCCCCTTCAACAAGCCCCTT
ACTCAACGAAGCAATGCCGTCCGTTTTTTAGCGGACTATTGCCTGAAGCCCATATGCGTACTGCTATTGCCCGTCAATTG
GGTATCAGTGAAAAAAATGATTTTGCCTTATTAGCAGCTATTGGTGGTGAGTGTGCCGGAGCTGTGATGATATTACCTCA
AGATACATCCATAACTCAGCTAAAGCCAGACTATAAAATTATCAAAAAACAGGATGTATTAGAAATCCTGCAAACCATGC
ATCAAAGACCCATGATAGTCGGTGAGGATGGAATTCGTTTATCCCTTGCTGGAGCTCAGGATAAACTTCCAGTTGCCATT
ATTGAAGGAAATCTCGCAATACCAATGAACGGTGCACCGAGTACTCATATTTTAAAACCAATTAATCGAGACTTTCCCTC
CTTAATTGAAAATGAATCTTTCTGCCTTAATCTGGCACAAAAAATTGGATTAAATGCTGTGGACGCATCAATCCATTATG
CTGATGGTACCCCTTATCTGTTGGTTAAACGTTATGATCGGGTTGAGACAAAGCAAGGAATCCAACGTCTTCATCAAGAA
GATTTTTGTCAGGCAATGGGCATTAGCCCTGAAATGAAATATCAGCGAGAAGGCGGCCCCCAAATTAGTGAGTGCTTTGG
TTTGATAAGAGAGATATCAAGCCTCCCTGTCCTTGACATAAAAGAATTATTACAAGGGATTCTGTTTAATGTCATTATTG
GCAACAATGATGCACATAGCAAAAACTTCTCTTTGCTCTATCATGGTTCAAAAGTTCGTTTAGCACCTTTCTACGATCTG
ATTTCAACCGTATATTATCCTAATCTTGCCAGTAAAATGGCGATGAAAGTTGGAAGTAAATATGATTTTGATGGCCTATT
TCCACGCCACTTTATACAAATGGCAGAGGAGGCTCGTTTATCGGGTGCCTTAGTGCGTAAAGAAGTCTTGAATCTAATTA
GCAAAATTCAAAAGAACATAACCGCCAGCCCCTTTACCAGCATCATTTTGCAACGTGCTGACAAATTATTTCAAAAGTTC
CAGAAGGCTTCAACAGGATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8467.85 Da        Isoelectric Point: 9.1200

>AT76349 WP_027227407.1 NZ_CP021259:2688907-2689134 [Legionella pneumophila]
MIQSPENIGRYIRKVRKELNVTQKDLALTAGTGLRFIIDLENGKPTCQIGKMLQVLQVLGIQLNLSHTDFENEKS

Download         Length: 228 bp

>AT76349 NZ_CP021259:2688907-2689134 [Legionella pneumophila]
ATGATTCAATCTCCAGAAAATATAGGACGTTATATTCGCAAAGTTCGTAAAGAACTTAATGTTACCCAAAAAGATTTGGC
TTTAACTGCTGGAACTGGATTGCGTTTTATTATCGATTTGGAAAATGGAAAGCCCACTTGCCAAATTGGAAAAATGCTGC
AAGTACTACAAGTACTTGGGATTCAACTCAACTTATCTCATACTGATTTCGAAAATGAAAAATCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References