Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 1267392..1268411 Replicon chromosome
Accession NZ_CP021259
Organism Legionella pneumophila strain D-7708

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag CA934_RS05870 Protein ID WP_106225107.1
Coordinates 1267842..1268411 (+) Length 190 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag CA934_RS05865 Protein ID WP_106225106.1
Coordinates 1267392..1267838 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA934_RS05845 1262886..1264079 + 1194 WP_106225102.1 DUF4263 domain-containing protein -
CA934_RS05850 1264284..1266038 - 1755 WP_106225103.1 DUF927 domain-containing protein -
CA934_RS05855 1266116..1266367 - 252 WP_061692146.1 hypothetical protein -
CA934_RS05860 1266791..1267150 + 360 WP_106225105.1 transcriptional regulator -
CA934_RS05865 1267392..1267838 + 447 WP_106225106.1 helix-turn-helix domain-containing protein Antitoxin
CA934_RS05870 1267842..1268411 + 570 WP_106225107.1 PIN domain-containing protein Toxin
CA934_RS05875 1268597..1269277 + 681 WP_106225108.1 hypothetical protein -
CA934_RS05880 1269298..1270515 - 1218 WP_106225109.1 integrase family protein -
CA934_RS05885 1270775..1271761 - 987 WP_106224842.1 IS30 family transposase -
CA934_RS05890 1271931..1272704 + 774 WP_106225110.1 hypothetical protein -
CA934_RS05895 1272885..1273256 + 372 WP_106225111.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - lpg1083 / lpg1106 / ravL / ravM / lem5 / ravN / ceg19 / lpg1124 / ravO / lpg1137 / cegC3 / lem7 / lpg1147 / lpg1148 / ravP / ravQ / lpg1158 / ravR 1157050..1372092 215042


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-113)

Antitoxin

Helix-turn-helix domain, group 17

(78-125)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 21871.37 Da        Isoelectric Point: 6.4858

>T76348 WP_106225107.1 NZ_CP021259:1267842-1268411 [Legionella pneumophila]
MVNFTVLYDACVLYPAPLRDLLMQLATCELYRAKWSERIHDEWIRNVLKNRPDLNIEILEKIRKTMNKSVLDCLVEHFED
IEQSLKLPDSNDNHVLAAAIVSGCDVILTFNIKDFPSKELDKYGIEAQHPDDFLMHLTDLNINKFCSAVKAVRTRLKNPP
KNIDEYLSTLKKQGLPKTAEFLLNHYSLL

Download         Length: 570 bp

>T76348 NZ_CP021259:1267842-1268411 [Legionella pneumophila]
ATGGTTAATTTTACAGTTTTATATGACGCATGTGTTCTTTATCCTGCACCACTACGCGATTTATTAATGCAATTAGCTAC
ATGTGAATTATATCGTGCTAAATGGTCTGAGCGAATTCATGATGAATGGATTAGGAATGTTTTAAAGAATAGGCCTGATT
TAAATATCGAAATTTTAGAAAAAATACGAAAAACCATGAATAAATCAGTATTGGATTGCTTGGTTGAGCATTTTGAGGAT
ATAGAACAATCACTGAAACTTCCTGACTCTAATGATAATCATGTTCTTGCAGCAGCTATTGTTTCTGGATGTGATGTTAT
TCTTACATTTAACATTAAAGATTTTCCCTCTAAAGAACTTGATAAGTATGGAATTGAAGCACAACATCCAGATGATTTTT
TAATGCATCTCACTGATCTAAATATAAATAAATTCTGTTCCGCTGTTAAAGCCGTGCGCACTCGTCTTAAAAACCCACCT
AAAAATATCGATGAATATTTGTCAACTTTAAAAAAACAGGGTTTACCTAAAACAGCCGAATTTTTATTAAACCATTATTC
ACTTCTTTAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16692.29 Da        Isoelectric Point: 9.8938

>AT76348 WP_106225106.1 NZ_CP021259:1267392-1267838 [Legionella pneumophila]
MARLTTEIRNPSKHDRGIAKQSFQQIRQLSISAKKTAFLEFEGVHVELPSSAVKLVVTILNEIAEGNSLTLIPQHAHLTT
QEAADMLNVSRPYFVKLLQEGKIPFEKIGNRRRVLARDVMAFKDKARAESEHALQELVDLAQKLDMGY

Download         Length: 447 bp

>AT76348 NZ_CP021259:1267392-1267838 [Legionella pneumophila]
ATGGCAAGGCTAACAACCGAAATTCGAAATCCCAGTAAACATGATAGAGGAATTGCTAAACAATCCTTTCAGCAAATTCG
TCAACTTTCCATATCTGCCAAAAAAACGGCCTTTTTAGAATTTGAAGGTGTTCATGTTGAGTTGCCTTCTTCAGCAGTTA
AGTTGGTTGTTACCATTTTGAATGAAATAGCAGAGGGTAATTCTTTAACATTAATTCCTCAACATGCCCATCTAACGACA
CAAGAAGCAGCAGATATGCTAAACGTCTCACGACCGTATTTTGTGAAGTTACTCCAAGAAGGAAAAATTCCTTTTGAAAA
AATAGGCAATCGACGTCGCGTACTAGCCCGTGATGTAATGGCATTTAAGGATAAGGCAAGAGCCGAGAGCGAACATGCAT
TACAAGAACTAGTAGATCTAGCCCAAAAATTAGATATGGGATATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References