Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 2870159..2871615 Replicon chromosome
Accession NZ_CP021256
Organism Legionella pneumophila strain D-4954

Toxin (Protein)


Gene name rlegT Uniprot ID -
Locus tag CA937_RS13040 Protein ID WP_062728144.1
Coordinates 2870159..2871010 (-) Length 284 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID -
Locus tag CA937_RS13045 Protein ID WP_062728146.1
Coordinates 2871007..2871615 (-) Length 203 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA937_RS13020 2865850..2866500 + 651 WP_106222082.1 helix-turn-helix domain-containing protein -
CA937_RS13025 2866613..2867842 - 1230 WP_106222084.1 integrase family protein -
CA937_RS13030 2868148..2868504 + 357 WP_106222086.1 hypothetical protein -
CA937_RS13035 2868942..2869976 + 1035 WP_106222088.1 hypothetical protein -
CA937_RS13040 2870159..2871010 - 852 WP_062728144.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
CA937_RS13045 2871007..2871615 - 609 WP_062728146.1 AbiEi antitoxin N-terminal domain-containing protein Antitoxin
CA937_RS13050 2872008..2873183 - 1176 WP_106174732.1 ISL3 family transposase -
CA937_RS13055 2873413..2874126 + 714 WP_152027454.1 hypothetical protein -
CA937_RS13060 2874186..2874383 - 198 Protein_2543 hypothetical protein -
CA937_RS13065 2874431..2874742 - 312 WP_062728338.1 cupin -
CA937_RS13070 2874758..2876050 - 1293 WP_062740169.1 ATP-grasp domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(35-263)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(9-55)


Sequences

Toxin        


Download         Length: 284 a.a.        Molecular weight: 31721.71 Da        Isoelectric Point: 6.7346

>T76341 WP_062728144.1 NZ_CP021256:c2871010-2870159 [Legionella pneumophila]
MTKNIGESVRSRLKNIAIKEGSDLNAVLTRYGLERLLYRIGESEYSNQFLLKGALLFNLWYDMPHRPTKDIDLLGFGDND
LASIKQTFSKICSISVDDGISFLSESVTVDSIKKDGDYTGARVELFGELAKAKIKIQIDIGYGDAVTPGPIDAHYPVLLS
DLPAPKIRTYPIYTVIAEKLHAIAFLGMANSRLKDYLDLYVLLSKEQLNNQVLAKAIQATFTRRGMTVPEALPIGLTDEF
ANDPTRESMWIAFLRKNELEQKPLSEVIAVIRNLIQMPFSFVK

Download         Length: 852 bp

>T76341 NZ_CP021256:c2871010-2870159 [Legionella pneumophila]
ATGACAAAAAATATTGGTGAGTCTGTGCGCTCACGTTTGAAGAATATAGCTATAAAAGAAGGTTCTGATTTAAACGCGGT
ATTAACTCGTTACGGATTAGAACGTTTGTTATATCGAATTGGAGAATCAGAATACTCTAATCAGTTTTTATTGAAAGGGG
CTTTACTATTTAACCTATGGTATGACATGCCCCATCGCCCAACTAAAGATATTGATTTATTGGGGTTTGGTGATAATGAT
CTAGCGTCTATTAAACAAACATTCAGTAAAATTTGCAGTATCTCAGTAGATGATGGAATAAGTTTTCTTTCGGAATCAGT
GACAGTAGACTCTATTAAAAAAGATGGGGATTATACTGGAGCAAGAGTTGAGTTATTTGGGGAGTTGGCGAAAGCAAAGA
TCAAAATACAAATTGATATTGGTTATGGTGATGCAGTTACCCCAGGACCAATAGACGCCCATTATCCTGTTCTTCTTAGT
GATCTACCTGCCCCTAAAATCCGCACCTATCCAATTTATACGGTAATTGCAGAAAAGCTGCACGCAATTGCATTCTTGGG
CATGGCGAATAGTCGATTAAAAGACTACTTGGATCTTTATGTATTATTAAGTAAAGAGCAGTTGAATAATCAAGTCTTGG
CTAAAGCAATACAAGCTACATTTACTCGCCGAGGCATGACAGTTCCAGAGGCTTTACCAATTGGCCTAACCGATGAGTTT
GCCAATGATCCAACTAGAGAATCAATGTGGATAGCTTTTTTGAGAAAGAATGAATTAGAGCAAAAGCCATTATCAGAAGT
AATTGCTGTGATCAGAAATTTGATCCAAATGCCATTCTCTTTTGTAAAATAA

Antitoxin


Download         Length: 203 a.a.        Molecular weight: 22967.88 Da        Isoelectric Point: 9.2687

>AT76341 WP_062728146.1 NZ_CP021256:c2871615-2871007 [Legionella pneumophila]
MKTKDSYKQKVLQMASKTGIVRMSDLTEMGITRATISRLVSENKLEKLASGLYCLSETELSEKESLVIIASRVPQAVFCL
LTALQIHDLTTQLPRKVWIAMPKGSHAPKMDYPPLKMVQYSDEAFSEGIEIIESDNIKLRVYNRAKTIADCFKHRNKIGI
DVAIEALKEAYSKNKVTVDELWHYAKICRVANVMRPYIETIQ

Download         Length: 609 bp

>AT76341 NZ_CP021256:c2871615-2871007 [Legionella pneumophila]
ATGAAGACAAAGGATAGCTATAAACAAAAAGTACTCCAGATGGCTAGTAAAACGGGCATTGTTCGAATGTCCGATCTAAC
CGAAATGGGGATCACTAGAGCGACTATTTCAAGGCTTGTTAGCGAAAACAAACTTGAAAAACTCGCTTCTGGGCTCTATT
GCTTGTCAGAGACTGAGCTTTCAGAAAAAGAAAGCCTGGTTATTATAGCAAGCCGAGTACCTCAAGCAGTGTTTTGCCTT
CTAACTGCTTTGCAGATTCATGATCTAACAACACAGCTACCTCGAAAAGTATGGATAGCTATGCCAAAAGGGAGTCATGC
GCCAAAAATGGATTATCCCCCGCTAAAAATGGTGCAATATTCCGATGAAGCCTTTAGTGAAGGAATTGAAATTATAGAAT
CAGATAATATTAAACTAAGAGTGTATAACCGTGCCAAGACAATTGCGGATTGTTTCAAACATCGCAATAAAATTGGCATT
GATGTCGCTATTGAAGCACTCAAAGAAGCTTATTCAAAAAATAAAGTAACAGTTGATGAACTATGGCATTATGCGAAAAT
TTGTCGCGTTGCAAACGTAATGCGTCCTTATATTGAGACAATTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References