Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 2834448..2835904 Replicon chromosome
Accession NZ_CP021256
Organism Legionella pneumophila strain D-4954

Toxin (Protein)


Gene name rlegT Uniprot ID -
Locus tag CA937_RS12850 Protein ID WP_014842352.1
Coordinates 2834448..2835299 (-) Length 284 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID -
Locus tag CA937_RS12855 Protein ID WP_027265135.1
Coordinates 2835296..2835904 (-) Length 203 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA937_RS12815 2829639..2829992 - 354 WP_014842347.1 conjugal transfer transcriptional regulator TraJ -
CA937_RS12820 2830407..2830751 + 345 WP_014842348.1 TraK family protein -
CA937_RS12825 2830751..2831476 + 726 WP_014842349.1 conjugal transfer protein TraL -
CA937_RS12830 2831476..2831916 + 441 WP_042754801.1 conjugal transfer protein TraM -
CA937_RS12835 2832081..2833115 + 1035 WP_027265137.1 putative DNA binding domain-containing protein -
CA937_RS16665 2833859..2833939 - 81 WP_152027460.1 transposase -
CA937_RS12845 2833948..2834367 + 420 Protein_2500 DUF2779 domain-containing protein -
CA937_RS12850 2834448..2835299 - 852 WP_014842352.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
CA937_RS12855 2835296..2835904 - 609 WP_027265135.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
CA937_RS12860 2836147..2836410 + 264 WP_014842354.1 hypothetical protein -
CA937_RS12865 2836410..2837171 + 762 WP_042754800.1 DUF3800 domain-containing protein -
CA937_RS12870 2837579..2838727 + 1149 WP_014842362.1 outer membrane beta-barrel protein -
CA937_RS12875 2838757..2839875 + 1119 WP_014842363.1 DUF3494 domain-containing protein -
CA937_RS16740 2840179..2840337 + 159 WP_154080660.1 hypothetical protein -
CA937_RS12880 2840385..2840726 + 342 WP_027265134.1 IS630 transposase-related protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(35-262)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(9-56)


Sequences

Toxin        


Download         Length: 284 a.a.        Molecular weight: 31702.65 Da        Isoelectric Point: 6.2785

>T76340 WP_014842352.1 NZ_CP021256:c2835299-2834448 [Legionella pneumophila]
MIKNIGESVRSRLKNIAVKEGSDFNAVLTRYGLERLLYRIGESEYSNQFLLKGALLFNLWYDMPHRPTKDIDLLGFGDND
LAYIKQTFSKICSIFADDGISFLSESVTVDTIKKDGGYTGARVELFGELAKAKIKIQIDIGYGDAVTPGPIDAHYPVLLS
DLPAPKIRTYPIYTVIAEKLHAIALLGMANGRLKDYLDLYVLLGNEQIDNQILAKAIQATFNRRGMDLPEALPIGLTDEF
ANDPSRESMWKAFLRKNELEQKPLTEVIAVIRNLIQVPYSLAK

Download         Length: 852 bp

>T76340 NZ_CP021256:c2835299-2834448 [Legionella pneumophila]
ATGATCAAAAATATTGGTGAGTCCGTACGCTCACGTTTGAAGAATATAGCTGTTAAAGAAGGTTCTGATTTTAATGCGGT
ATTGACTCGTTATGGTCTAGAGCGTTTGTTGTATCGAATTGGAGAATCAGAATATTCTAACCAGTTTTTGTTGAAAGGTG
CCTTACTGTTTAACCTATGGTACGACATGCCCCATCGCCCAACTAAAGATATTGATTTATTGGGATTTGGTGATAACGAT
CTGGCGTATATTAAGCAAACGTTCAGTAAAATTTGCAGCATCTTTGCAGATGATGGAATAAGTTTTCTGTCTGAATCAGT
GACGGTTGACACTATCAAAAAAGATGGAGGTTATACTGGAGCAAGAGTTGAGTTATTTGGGGAATTGGCGAAAGCAAAGA
TTAAAATACAAATTGATATAGGTTATGGTGATGCAGTTACGCCTGGGCCAATAGATGCCCATTATCCCGTACTTCTTAGT
GATCTTCCTGCCCCTAAAATCCGTACTTATCCAATTTATACGGTAATTGCAGAAAAGCTGCACGCAATTGCATTATTGGG
CATGGCGAATGGTCGATTAAAAGACTACTTGGATCTTTATGTATTATTAGGTAATGAACAGATAGATAATCAAATCTTGG
CTAAAGCTATACAAGCCACATTTAATCGTCGAGGTATGGATCTTCCTGAAGCACTGCCTATTGGCCTGACCGATGAGTTT
GCTAACGACCCAAGCAGGGAGTCAATGTGGAAAGCCTTTTTGAGAAAAAATGAACTAGAGCAGAAACCATTAACTGAAGT
CATTGCTGTGATCAGAAATTTGATTCAAGTGCCATATTCTTTGGCAAAGTAA

Antitoxin


Download         Length: 203 a.a.        Molecular weight: 22977.01 Da        Isoelectric Point: 9.6557

>AT76340 WP_027265135.1 NZ_CP021256:c2835904-2835296 [Legionella pneumophila]
MKTEVNNKQKVLQMASKTGVIRMSDLTKKGITRATISRLVSENKLEKLAPGLYCLPETEFSEKESLVIIASRVPQAVFCL
LTALQIHDLTTQLPRKVWIAMPKGSHAPKMDYPPLKMVQYSDEAFSEGIEIIESDNIKLRVYNRAKTIADCFKHRNKIGL
DVAIEALKEAYTKNKVIVDELWHYAKICRVANVMRPYIEAIQ

Download         Length: 609 bp

>AT76340 NZ_CP021256:c2835904-2835296 [Legionella pneumophila]
ATGAAGACAGAGGTCAACAATAAACAAAAAGTTCTCCAGATGGCTAGTAAAACGGGCGTTATTAGAATGTCCGATCTGAC
CAAGAAGGGGATCACTAGAGCGACCATTTCAAGGCTTGTTAGCGAAAACAAACTTGAAAAACTCGCTCCTGGACTCTATT
GCCTGCCCGAGACTGAGTTTTCAGAAAAGGAAAGCCTGGTTATTATAGCAAGTCGAGTACCTCAAGCAGTGTTTTGCCTG
CTAACTGCTTTGCAGATTCATGATCTAACAACACAGCTACCTCGAAAAGTATGGATAGCTATGCCAAAAGGGAGTCATGC
GCCAAAAATGGATTATCCTCCGCTAAAAATGGTGCAATATTCAGATGAAGCCTTTAGTGAAGGAATTGAAATTATAGAAT
CAGATAATATTAAACTAAGGGTGTATAACCGTGCCAAGACAATTGCAGATTGTTTCAAACATCGCAATAAAATTGGACTT
GATGTGGCCATTGAAGCGCTCAAAGAGGCTTATACAAAAAATAAAGTCATAGTTGATGAACTATGGCATTATGCGAAAAT
TTGTCGCGTTGCAAACGTAATGCGTCCTTATATTGAGGCAATTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References