Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 514964..515441 Replicon chromosome
Accession NZ_CP021255
Organism Desulfobulbus oralis strain HOT041/ORNL

Toxin (Protein)


Gene name pasB Uniprot ID -
Locus tag CAY53_RS02085 Protein ID WP_104935724.1
Coordinates 515172..515441 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID -
Locus tag CAY53_RS02080 Protein ID WP_104935723.1
Coordinates 514964..515188 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CAY53_RS02050 510113..510556 - 444 WP_104935618.1 IS200/IS605 family transposase -
CAY53_RS02055 511020..511759 + 740 Protein_411 IS5 family transposase -
CAY53_RS02060 512183..513439 + 1257 WP_104935672.1 ISL3 family transposase -
CAY53_RS02075 513735..514591 + 857 Protein_413 site-specific integrase -
CAY53_RS02080 514964..515188 + 225 WP_104935723.1 TraY domain-containing protein Antitoxin
CAY53_RS02085 515172..515441 + 270 WP_104935724.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CAY53_RS02090 515478..515831 + 354 WP_104935725.1 conjugal transfer protein TraJ -
CAY53_RS02095 515828..518137 + 2310 WP_104935726.1 relaxase/mobilization nuclease domain-containing protein -
CAY53_RS12440 518205..518618 - 414 WP_146106369.1 hypothetical protein -
CAY53_RS12445 518661..519260 - 600 WP_146106370.1 hypothetical protein -
CAY53_RS02105 519235..519474 - 240 WP_017866015.1 hypothetical protein -
CAY53_RS02110 519505..520053 - 549 WP_104935728.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 514964..520053 5089


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-88)

Antitoxin

Relaxosome protein TraY

(4-49)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10363.07 Da        Isoelectric Point: 10.2161

>T76338 WP_104935724.1 NZ_CP021255:515172-515441 [Desulfobulbus oralis]
MGWKIELARAAERDLDKLDPQVARRILVFLHGRLAELDDPRSIGEPLKGSKLGEFWKYRVGDYRVISSIEDKVLTILVVR
IGNRREVYR

Download         Length: 270 bp

>T76338 NZ_CP021255:515172-515441 [Desulfobulbus oralis]
ATGGGCTGGAAAATTGAGCTTGCCCGCGCTGCAGAACGTGATTTGGATAAACTCGATCCTCAGGTGGCCAGACGTATTCT
TGTTTTTCTGCATGGCCGTCTGGCTGAACTGGACGACCCACGCAGTATCGGTGAGCCACTCAAAGGATCGAAGCTGGGTG
AATTCTGGAAGTACCGCGTCGGTGATTACAGGGTAATCAGCAGCATCGAGGACAAGGTGCTGACAATCCTCGTTGTGAGA
ATTGGCAATCGTCGAGAGGTCTACAGATAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8402.63 Da        Isoelectric Point: 4.4633

>AT76338 WP_104935723.1 NZ_CP021255:514964-515188 [Desulfobulbus oralis]
MLAIRLPAEIEARLDAMAKATGRTKTFYARQAILEYLDDLEDLYLAEQRLSEIRTGASEVVALEEVVKRYGLEN

Download         Length: 225 bp

>AT76338 NZ_CP021255:514964-515188 [Desulfobulbus oralis]
ATGCTCGCAATCAGACTGCCCGCTGAGATAGAAGCCCGGCTTGACGCCATGGCAAAGGCCACTGGCCGAACCAAAACATT
CTATGCCCGGCAAGCCATTCTCGAATACCTGGATGATCTTGAAGACCTGTATCTGGCTGAGCAACGATTGAGCGAGATCA
GAACCGGAGCGTCGGAGGTTGTGGCTCTTGAGGAAGTGGTGAAGCGCTATGGGCTGGAAAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References