Detailed information of TA system TA076337

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 2220..3220
• Replicon: plasmid pCs-Na-1
• Accession: NZ_CP021253
• Organism: Corynebacterium striatum strain KC-Na-01

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: CBE89_RS13115
• Protein ID: WP_086892511.1
• Coordinates: 2666..3220 (+)
• Length: 185 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: CBE89_RS13110
• Protein ID: WP_086892529.1
• Coordinates: 2220..2669 (+)
• Length: 150 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CBE89_RS13735	726..875	-	150	WP_165033318.1	hypothetical protein	-
CBE89_RS13100	1187..1780	-	594	WP_086892510.1	recombinase family protein	-
CBE89_RS13105	1780..2046	-	267	WP_205690730.1	hypothetical protein	-
CBE89_RS13110	2220..2669	+	450	WP_086892529.1	helix-turn-helix domain-containing protein	Antitoxin
CBE89_RS13115	2666..3220	+	555	WP_086892511.1	PIN domain-containing protein	Toxin
CBE89_RS13120	3285..3500	+	216	WP_205690729.1	hypothetical protein	-
CBE89_RS13130	3814..4530	-	717	WP_157420837.1	GNAT family N-acetyltransferase	-
CBE89_RS13140	5215..6407	+	1193	WP_157420838.1	IS3 family transposase	-
CBE89_RS13145	6626..7429	-	804	WP_086892513.1	hypothetical protein	-
CBE89_RS13150	7429..8076	-	648	WP_010187823.1	NAD(P)H-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..25501	25501

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-112)

Antitoxin

• Helix-turn-helix domain, group 17 (79-126)

Sequences

Toxin

Protein

• Length: 185 a.a.
• Molecular weight: 20528.32 Da
• Isoelectric Point: 4.3345

>T76337 WP_086892511.1 NZ_CP021253:2666-3220 [Corynebacterium striatum]
VSGFTVIYDANVLYPNMLRDILIRLAGTGIYQARWTEDILDEVFRNLQANRPDLDPSKLRRTRELMCRAVDDCLVTGYED
LIESLSLPDPDDRHVLAAAIRCGAQVIVTENARDFPQDVMDKYGIEIQGADEFLCDQIDLFGTRVHQAITYAAAAFKNPP
MTIDDVLDALARAGAPSAADLLRR

Nucleotide

• Length: 555 bp

>T76337 NZ_CP021253:2666-3220 [Corynebacterium striatum]
GTGAGTGGCTTTACCGTTATCTACGACGCCAACGTGCTGTACCCCAATATGTTGCGTGACATCCTGATCCGACTGGCAGG
CACGGGCATTTACCAAGCCCGGTGGACCGAGGACATCCTGGATGAGGTTTTTCGCAACCTCCAGGCCAACCGGCCAGATC
TTGACCCCAGTAAACTACGCCGAACCCGGGAGCTGATGTGTCGGGCTGTGGATGATTGTCTGGTGACTGGGTATGAAGAT
TTAATTGAGTCATTGTCCTTGCCGGATCCTGATGACCGTCATGTTCTTGCTGCTGCCATCAGGTGTGGTGCCCAGGTGAT
TGTCACCGAAAACGCGCGGGATTTTCCTCAAGACGTGATGGATAAATACGGCATCGAGATCCAGGGTGCTGATGAGTTTT
TATGTGATCAGATTGATCTGTTCGGTACTCGTGTCCATCAGGCTATTACCTATGCCGCGGCGGCGTTCAAAAATCCCCCC
ATGACCATTGATGATGTACTTGACGCGCTAGCCAGGGCGGGAGCTCCTTCCGCAGCGGACTTACTCCGGAGATAG

Antitoxin

Protein

• Length: 150 a.a.
• Molecular weight: 16490.76 Da
• Isoelectric Point: 6.0987

>AT76337 WP_086892529.1 NZ_CP021253:2220-2669 [Corynebacterium striatum]
MAYLQDNEIASTAATAREALQKINRVLSDTSTNKDVKVVVEQSDEVIRLPREVATVLREILVNSVAGRSVSVIPMRAELT
TQQAANLLNVSRPHVIKLMDDGILPGHKVGTHRRIYAADVQAYKHQRDIEARTAADDLTALTEEMGLYE

Nucleotide

• Length: 450 bp

>AT76337 NZ_CP021253:2220-2669 [Corynebacterium striatum]
ATGGCCTATCTACAAGACAACGAAATCGCTAGCACTGCGGCCACAGCCCGTGAGGCTTTGCAGAAAATCAACCGCGTCCT
AAGCGATACATCTACCAATAAGGACGTCAAGGTCGTAGTGGAGCAGTCTGATGAGGTCATCCGTCTACCCAGAGAAGTCG
CCACCGTCCTCCGGGAAATCCTGGTCAATTCAGTAGCCGGCAGATCGGTAAGCGTGATCCCCATGCGGGCCGAGCTAACC
ACCCAGCAAGCAGCTAACCTGCTTAATGTTTCTCGTCCGCATGTCATTAAATTGATGGATGACGGCATCTTGCCTGGACA
TAAGGTTGGTACTCATCGACGTATCTATGCGGCCGACGTGCAGGCCTATAAACACCAACGAGATATCGAGGCACGTACAG
CTGCAGATGATCTCACCGCCCTAACCGAGGAGATGGGGCTGTACGAGTGA