Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1473208..1473875 Replicon plasmid pSymB
Accession NZ_CP021218
Organism Sinorhizobium meliloti RU11/001

Toxin (Protein)


Gene name vapC Uniprot ID A0A8B3N559
Locus tag SMRU11_RS18120 Protein ID WP_017266625.1
Coordinates 1473432..1473875 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q92WE1
Locus tag SMRU11_RS18115 Protein ID WP_010975287.1
Coordinates 1473208..1473435 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMRU11_RS18090 1468601..1469482 - 882 WP_003525869.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
SMRU11_RS18095 1469600..1470892 - 1293 WP_017266622.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
SMRU11_RS18105 1471262..1472551 + 1290 WP_017266623.1 SDR family oxidoreductase -
SMRU11_RS18110 1472551..1473024 + 474 WP_017266624.1 DUF2269 family protein -
SMRU11_RS18115 1473208..1473435 + 228 WP_010975287.1 hypothetical protein Antitoxin
SMRU11_RS18120 1473432..1473875 + 444 WP_017266625.1 PIN domain-containing protein Toxin
SMRU11_RS18125 1473891..1474829 - 939 WP_017266626.1 choline ABC transporter substrate-binding protein -
SMRU11_RS18130 1474898..1475728 - 831 WP_013849981.1 SDR family oxidoreductase -
SMRU11_RS18135 1475725..1476222 - 498 WP_017266627.1 acetone carboxylase subunit gamma -
SMRU11_RS18140 1476226..1478418 - 2193 WP_013849983.1 hydantoinase B/oxoprolinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - htpB 1..1686813 1686813


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-131)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 15638.95 Da        Isoelectric Point: 6.6378

>T76322 WP_017266625.1 NZ_CP021218:1473432-1473875 [Sinorhizobium meliloti RU11/001]
VTFLLDVNVLIALIDPSHIGHDDAHEWFASMGQTAWATCPITENGVIRIVGNPEYPNSPGSPLPVMEIVAKLRSLPGHVF
WPDDVSLVGSSDIIPSKILTSGQVTDTYLLALAKARGGKLATFDRKLSAAAVTKGNSALHLIATNRS

Download         Length: 444 bp

>T76322 NZ_CP021218:1473432-1473875 [Sinorhizobium meliloti RU11/001]
GTGACTTTCCTGCTCGACGTCAATGTGCTGATTGCCTTGATCGATCCGAGCCATATAGGCCATGATGATGCGCACGAATG
GTTCGCGTCGATGGGTCAGACCGCGTGGGCCACCTGCCCAATTACCGAAAATGGTGTCATCCGGATCGTCGGCAATCCCG
AATATCCCAATTCTCCCGGCTCACCGTTACCCGTGATGGAGATCGTCGCCAAATTGCGGTCGCTCCCCGGTCATGTTTTT
TGGCCGGACGATGTGAGCCTTGTCGGGTCAAGTGATATCATCCCATCGAAAATCCTGACTTCGGGGCAGGTGACTGACAC
CTATCTGCTTGCGCTCGCCAAGGCGCGTGGGGGCAAGCTGGCGACATTCGATCGCAAGCTGTCGGCAGCGGCGGTCACGA
AGGGCAATTCCGCCTTGCACCTGATCGCGACGAATAGGTCGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8174.39 Da        Isoelectric Point: 9.1096

>AT76322 WP_010975287.1 NZ_CP021218:1473208-1473435 [Sinorhizobium meliloti RU11/001]
MRTTLAIDDDVLIAAKAMATQQQRSVGEVISELARRSLRRPRSGGERNGIPLLSPRPDAPPVTLEIVNALRDELA

Download         Length: 228 bp

>AT76322 NZ_CP021218:1473208-1473435 [Sinorhizobium meliloti RU11/001]
ATGAGAACGACCTTGGCTATTGACGACGATGTCCTGATCGCCGCAAAGGCAATGGCGACCCAACAGCAGCGGAGCGTCGG
CGAGGTAATTTCCGAACTGGCGAGGCGTTCTCTGCGCCGGCCGCGCAGCGGCGGCGAGCGTAATGGAATTCCTCTCCTGT
CGCCTCGTCCGGACGCACCGCCCGTGACGCTCGAGATCGTCAACGCCCTGCGTGACGAACTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B3N559

Antitoxin

Source ID Structure
AlphaFold DB Q92WE1

References