Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-Xre |
| Location | 1115868..1116800 | Replicon | plasmid pSymB |
| Accession | NZ_CP021218 | ||
| Organism | Sinorhizobium meliloti RU11/001 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | F7XGP1 |
| Locus tag | SMRU11_RS16300 | Protein ID | WP_014530511.1 |
| Coordinates | 1115868..1116422 (-) | Length | 185 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | F7XGP2 |
| Locus tag | SMRU11_RS16305 | Protein ID | WP_014530512.1 |
| Coordinates | 1116429..1116800 (-) | Length | 124 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SMRU11_RS16280 | 1111534..1112409 | + | 876 | WP_013850796.1 | sulfate ABC transporter permease subunit CysW | - |
| SMRU11_RS16285 | 1112425..1113531 | + | 1107 | WP_014530508.1 | sulfate/molybdate ABC transporter ATP-binding protein | - |
| SMRU11_RS16290 | 1113643..1115013 | + | 1371 | WP_015008367.1 | FAD-binding oxidoreductase | - |
| SMRU11_RS16295 | 1115098..1115869 | - | 772 | Protein_1005 | IS630 family transposase | - |
| SMRU11_RS16300 | 1115868..1116422 | - | 555 | WP_014530511.1 | RES family NAD+ phosphorylase | Toxin |
| SMRU11_RS16305 | 1116429..1116800 | - | 372 | WP_014530512.1 | DUF2384 domain-containing protein | Antitoxin |
| SMRU11_RS16310 | 1116877..1117662 | - | 786 | WP_014530513.1 | crotonase/enoyl-CoA hydratase family protein | - |
| SMRU11_RS16315 | 1117659..1118528 | - | 870 | WP_014530514.1 | hydroxymethylglutaryl-CoA lyase | - |
| SMRU11_RS16320 | 1118525..1120513 | - | 1989 | WP_014530515.1 | acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha | - |
| SMRU11_RS16325 | 1120530..1120913 | - | 384 | WP_029727977.1 | RidA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | htpB | 1..1686813 | 1686813 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 185 a.a. Molecular weight: 20449.31 Da Isoelectric Point: 6.4901
>T76321 WP_014530511.1 NZ_CP021218:c1116422-1115868 [Sinorhizobium meliloti RU11/001]
MRKHIPPASRPDSEPTSPVEPITLWRAFVPRWAHMPLSGAGAARFGGRWNPIGMPAIYAARELSTAWAEYNQGFVQHPAL
IVQLELRGARLADLTDASVLLELGVDEAIHRCEWRDALDKGAVPETHRLQSELLARDYHGVIYPSFMSPGGTCVALWRWN
GAEEPRLDVIDPDGRLPKSPASWV
MRKHIPPASRPDSEPTSPVEPITLWRAFVPRWAHMPLSGAGAARFGGRWNPIGMPAIYAARELSTAWAEYNQGFVQHPAL
IVQLELRGARLADLTDASVLLELGVDEAIHRCEWRDALDKGAVPETHRLQSELLARDYHGVIYPSFMSPGGTCVALWRWN
GAEEPRLDVIDPDGRLPKSPASWV
Download Length: 555 bp
>T76321 NZ_CP021218:c1116422-1115868 [Sinorhizobium meliloti RU11/001]
ATGAGGAAACACATTCCGCCCGCATCGCGACCCGATTCGGAACCGACGTCGCCGGTCGAGCCGATAACGCTCTGGCGCGC
CTTCGTTCCGCGCTGGGCACATATGCCGCTATCCGGCGCGGGTGCCGCTCGCTTCGGTGGCCGCTGGAACCCGATCGGCA
TGCCTGCGATTTATGCTGCGCGCGAGCTTTCCACTGCCTGGGCTGAATATAATCAGGGTTTCGTCCAGCATCCGGCGCTC
ATCGTGCAGCTCGAGTTACGCGGGGCGAGGCTCGCGGACCTCACGGATGCCAGCGTTCTTCTGGAGCTTGGTGTGGATGA
GGCGATCCATCGCTGCGAATGGCGTGATGCGCTCGACAAAGGCGCGGTGCCGGAGACCCACAGGCTGCAGTCGGAGCTTC
TGGCGCGCGACTATCACGGGGTGATCTATCCATCCTTCATGTCGCCCGGCGGCACCTGCGTCGCGCTCTGGCGCTGGAAC
GGTGCGGAAGAACCGCGTCTCGACGTCATCGATCCCGATGGCCGGCTGCCGAAATCGCCCGCTTCATGGGTTTGA
ATGAGGAAACACATTCCGCCCGCATCGCGACCCGATTCGGAACCGACGTCGCCGGTCGAGCCGATAACGCTCTGGCGCGC
CTTCGTTCCGCGCTGGGCACATATGCCGCTATCCGGCGCGGGTGCCGCTCGCTTCGGTGGCCGCTGGAACCCGATCGGCA
TGCCTGCGATTTATGCTGCGCGCGAGCTTTCCACTGCCTGGGCTGAATATAATCAGGGTTTCGTCCAGCATCCGGCGCTC
ATCGTGCAGCTCGAGTTACGCGGGGCGAGGCTCGCGGACCTCACGGATGCCAGCGTTCTTCTGGAGCTTGGTGTGGATGA
GGCGATCCATCGCTGCGAATGGCGTGATGCGCTCGACAAAGGCGCGGTGCCGGAGACCCACAGGCTGCAGTCGGAGCTTC
TGGCGCGCGACTATCACGGGGTGATCTATCCATCCTTCATGTCGCCCGGCGGCACCTGCGTCGCGCTCTGGCGCTGGAAC
GGTGCGGAAGAACCGCGTCTCGACGTCATCGATCCCGATGGCCGGCTGCCGAAATCGCCCGCTTCATGGGTTTGA
Antitoxin
Download Length: 124 a.a. Molecular weight: 13117.25 Da Isoelectric Point: 9.6233
>AT76321 WP_014530512.1 NZ_CP021218:c1116800-1116429 [Sinorhizobium meliloti RU11/001]
MMAVDFQIAAARFGDDHSPFLSARLVADWLGVTLAELAKLIGVARNTLTAKSGARKVDSALSKVVRILAMASEMAGDEAR
AVIWFKHQPIPGWAGKTAFDLVGEGKADKVLAYLESVRAGVYA
MMAVDFQIAAARFGDDHSPFLSARLVADWLGVTLAELAKLIGVARNTLTAKSGARKVDSALSKVVRILAMASEMAGDEAR
AVIWFKHQPIPGWAGKTAFDLVGEGKADKVLAYLESVRAGVYA
Download Length: 372 bp
>AT76321 NZ_CP021218:c1116800-1116429 [Sinorhizobium meliloti RU11/001]
ATGATGGCCGTTGATTTCCAGATAGCTGCAGCCCGTTTCGGGGACGATCATTCCCCGTTTCTCTCGGCCCGCCTTGTCGC
CGACTGGTTGGGCGTCACGCTCGCCGAACTCGCCAAGCTGATCGGTGTCGCCCGCAATACGCTGACGGCGAAATCCGGCG
CCCGGAAGGTCGACAGCGCCTTGAGCAAGGTCGTCCGCATCCTCGCCATGGCTTCCGAAATGGCGGGCGACGAAGCCCGC
GCCGTCATCTGGTTCAAGCACCAGCCTATCCCCGGCTGGGCCGGCAAGACGGCGTTCGATCTGGTCGGCGAGGGCAAGGC
CGACAAGGTGCTCGCCTATCTCGAATCGGTACGTGCCGGCGTCTACGCTTAA
ATGATGGCCGTTGATTTCCAGATAGCTGCAGCCCGTTTCGGGGACGATCATTCCCCGTTTCTCTCGGCCCGCCTTGTCGC
CGACTGGTTGGGCGTCACGCTCGCCGAACTCGCCAAGCTGATCGGTGTCGCCCGCAATACGCTGACGGCGAAATCCGGCG
CCCGGAAGGTCGACAGCGCCTTGAGCAAGGTCGTCCGCATCCTCGCCATGGCTTCCGAAATGGCGGGCGACGAAGCCCGC
GCCGTCATCTGGTTCAAGCACCAGCCTATCCCCGGCTGGGCCGGCAAGACGGCGTTCGATCTGGTCGGCGAGGGCAAGGC
CGACAAGGTGCTCGCCTATCTCGAATCGGTACGTGCCGGCGTCTACGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A222K2B4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A222K374 |