Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4763329..4763983 Replicon chromosome
Accession NZ_CP021202
Organism Escherichia coli strain Z1002

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag CA268_RS24475 Protein ID WP_000244781.1
Coordinates 4763329..4763736 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag CA268_RS24480 Protein ID WP_000354046.1
Coordinates 4763717..4763983 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA268_RS24455 4759286..4761019 - 1734 WP_000813233.1 single-stranded-DNA-specific exonuclease RecJ -
CA268_RS24460 4761025..4761735 - 711 WP_000715222.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CA268_RS24465 4761760..4762656 - 897 WP_000806650.1 site-specific tyrosine recombinase XerD -
CA268_RS24470 4762768..4763289 + 522 WP_001055874.1 flavodoxin FldB -
CA268_RS24475 4763329..4763736 - 408 WP_000244781.1 protein YgfX Toxin
CA268_RS24480 4763717..4763983 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
CA268_RS24485 4764226..4765206 + 981 WP_000886087.1 tRNA-modifying protein YgfZ -
CA268_RS24490 4765283..4765942 - 660 WP_000250274.1 hemolysin III family protein -
CA268_RS24495 4766106..4766417 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
CA268_RS24500 4766462..4767895 + 1434 WP_001394742.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T76257 WP_000244781.1 NZ_CP021202:c4763736-4763329 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T76257 NZ_CP021202:c4763736-4763329 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGTG
TTCGCAGCCAGCGACGCATTAATGCTCGCCAGGGAGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT76257 WP_000354046.1 NZ_CP021202:c4763983-4763717 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT76257 NZ_CP021202:c4763983-4763717 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTCAACTGGCTGATGAATCATGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References