Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1924793..1925411 Replicon chromosome
Accession NZ_CP021202
Organism Escherichia coli strain Z1002

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag CA268_RS09865 Protein ID WP_001291435.1
Coordinates 1924793..1925011 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag CA268_RS09870 Protein ID WP_000344800.1
Coordinates 1925037..1925411 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA268_RS09830 1920082..1920654 + 573 WP_000779831.1 YbaY family lipoprotein -
CA268_RS09835 1920685..1920996 - 312 WP_000409911.1 MGMT family protein -
CA268_RS09845 1921375..1921728 + 354 WP_000878140.1 DUF1428 domain-containing protein -
CA268_RS09850 1921770..1923320 - 1551 WP_001577872.1 cyclic-guanylate-specific phosphodiesterase PdeB -
CA268_RS09855 1923484..1923954 - 471 WP_001490888.1 YlaC family protein -
CA268_RS09860 1924070..1924621 - 552 WP_001522034.1 maltose O-acetyltransferase -
CA268_RS09865 1924793..1925011 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
CA268_RS09870 1925037..1925411 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
CA268_RS09875 1925957..1929106 - 3150 WP_001132480.1 multidrug efflux RND transporter permease subunit -
CA268_RS09880 1929129..1930322 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T76234 WP_001291435.1 NZ_CP021202:c1925011-1924793 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T76234 NZ_CP021202:c1925011-1924793 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT76234 WP_000344800.1 NZ_CP021202:c1925411-1925037 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT76234 NZ_CP021202:c1925411-1925037 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References